GPR37 Gene Summary
This gene is a member of the G protein-coupled receptor family. The encoded protein contains seven transmembrane domains and is found in cell and endoplasmic reticulum membranes. G protein-coupled receptors are involved in translating outside signals into G protein mediated intracellular effects. This gene product interacts with Parkin and is involved in juvenile Parkinson disease. [provided by RefSeq, Oct 2012]
Details
| Type | Protein Coding |
| Official Symbol | GPR37 |
| Official Name | G protein-coupled receptor 37 [Source:HGNC Symbol;Acc:HGNC:4494] |
| Ensembl ID | ENSG00000170775 |
| Bio databases IDs | |
| Aliases | G protein-coupled receptor 37, endothelin receptor type B-like |
| Synonyms | EDNRBL,G protein-coupled receptor 37,hET(B)R-LP,PAELR |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- G-protein coupled peptide receptor
- ubiquitin protein ligase binding
- peptide binding
- Cholecystokinin A receptor, N-terminal
- Hsp70 protein binding
- neuropeptide receptor
- heat shock protein binding
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
- PDZ-domain binding
- neuropeptide binding
- 7 transmembrane receptor (rhodopsin family)
Pathways
Biological processes and signaling networks where the GPR37 gene plays a role, providing insight into its function and relevance in health or disease.
- Adrenomedullin signaling pathway
- Breast Cancer Regulation by Stathmin1
- Cellular Effects of Sildenafil (Viagra)
- CREB Signaling in Neurons
- FAK Signaling
- G-Protein Coupled Receptor Signaling
- GABA Receptor Signaling
- Gustation Pathway
- Neuropathic Pain Signaling In Dorsal Horn Neurons
- Parkinson's Signaling
- Phagosome Formation
- Serotonin Receptor Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- Huntington disease
- schizophrenia
- lung squamous cell carcinoma
- squamous cell lung cancer
- hemangioma
- angiomatosis
- autosomal recessive juvenile parkinsonism
- non-small cell lung cancer
role in cell
- apoptosis
- expression in
- phosphorylation in
- migration
- cell death
- degeneration
- activation
- function
- glycolysis in
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- perinuclear region
- cellular membrane
- Endoplasmic Reticulum
- presynaptic membrane
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the GPR37 gene, providing context for its role in the cell.
biological PROCESS
Functions and activities the gene product is involved in
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
- dopamine biosynthetic process
- locomotion involved in locomotory behavior
- neuropeptide signaling pathway
- G-protein coupled receptor signaling pathway
- positive regulation of MAPK cascade
- cellular response to reactive oxygen species
- positive regulation of dopamine metabolic process
- dendrite development
cellular COMPONENT
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- dendrite
- ubiquitin ligase complex
- cytoplasm
- receptor complex
- endoplasmic reticulum
- synapse
- plasma membrane
- cell surface
molecular FUNCTION
What the gene product does at the molecular level
- heat shock protein binding
- G-protein coupled receptor activity
- G-protein coupled peptide receptor activity
- neuropeptide binding
- protein binding
- ubiquitin protein ligase binding
- neuropeptide receptor activity
- PDZ domain binding
- peptide binding
- Hsp70 protein binding