Adcy3 Gene Summary [Mouse]
Enables adenylate cyclase activity. Involved in several processes, including cAMP biosynthetic process; cellular response to forskolin; and olfactory learning. Acts upstream of or within sensory perception of smell. Located in ciliary membrane. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Used to study major depressive disorder. Orthologous to human ADCY3 (adenylate cyclase 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Adcy3 |
| Official Name | adenylate cyclase 3 [Source:MGI Symbol;Acc:MGI:99675] |
| Ensembl ID | ENSMUSG00000020654 |
| Bio databases IDs | |
| Aliases | adenylate cyclase 3 |
| Synonyms | AC3, ACIII, adenylate cyclase 3, mKIAA0511 |
| Species | Mouse, Mus musculus |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Adcy3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- adenylate cyclase
- calcium/calmodulin-responsive adenylate cyclase
- Class III nucleotidyl cyclases
- enzyme
- protein binding
- Adenylyl- / guanylyl cyclase, catalytic domain
Pathways
Biological processes and signaling networks where the Adcy3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
- cyclic AMP
- NRP1
- creatinine
- renin
disease
- obesity
- myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis
- hyperphagia
- anosmia
- asthenozoospermia
phenotypes
- decreased bone mineral content
- increased circulating creatine kinase level
- increased erythrocyte cell number
- increased hematocrit
- increased hemoglobin content
- preweaning lethality incomplete penetrance
- abnormal bone mineralization
- abnormal circulating creatine kinase level
- abnormal erythrocyte cell number
- abnormal fertility/fecundity
- abnormal hematocrit
- abnormal hemoglobin content
- abnormal olfaction
- abnormal olfactory bulb morphology
- abnormal olfactory system physiology
- abnormal sensory neuron innervation pattern
- anosmia
- asthenozoospermia
- decreased body weight
- decreased brown fat cell size
- decreased circulating glucose level
- decreased circulating insulin level
- decreased circulating leptin level
- decreased circulating renin level
- decreased erythrocyte cell number
- decreased litter size
- decreased percent body fat/body weight
- decreased renal glomerular filtration rate
- decreased susceptibility to diet-induced obesity
- decreased susceptibility to hepatic steatosis
- decreased total body fat amount
- decreased white fat cell size
- hyperactivity
- impaired fertilization
- impaired olfaction
- impaired sperm capacitation
- increased circulating creatinine level
- increased oxygen consumption
- no abnormal phenotype detected
- obese
- postnatal lethality complete penetrance
- postnatal lethality incomplete penetrance
- premature acrosome reaction
- reduced female fertility
- reduced male fertility
role in cell
- formation
- function
- motility
- elongation
- excitatory postsynaptic potential
- transmission
- response by
- cytostasis
- projection
- branching in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cilia
- cellular membrane
- Plasma Membrane
- Golgi Apparatus
- axonemes
- olfactory cilia
- primary cilia
- perikaryon
- dendrites
- dendritic knobs
- sensory axons