Hepatic Fibrosis / Hepatic Stellate Cell Activation
Hepatic fibrosis is a chronic liver disease associated with an accumulation of extracellular matrix (ECM) proteins. Causative agents include hepatotoxins like excessive ethanol, bile acids, glucose and free fatty acids. Hepatotoxins initiate a cascade of pro-inflammatory events which eventually activate Hepatic stellate cells (HSCs). Activated HSCs secrete cytokines that perpetuate their activated state. Continued liver injury results in an accumulation of activated HSCs and myofibroblasts which in turn synthesize large amounts of ECM, mainly collagen, leading to tissue fibrosis and eventually to liver cirrhosis...
Pathway Summary
Hepatic fibrosis is a chronic liver disease associated with an accumulation of extracellular matrix (ECM) proteins. Causative agents include hepatotoxins like excessive ethanol, bile acids, glucose and free fatty acids. Hepatotoxins initiate a cascade of pro-inflammatory events which eventually activate Hepatic stellate cells (HSCs). Activated HSCs secrete cytokines that perpetuate their activated state. Continued liver injury results in an accumulation of activated HSCs and myofibroblasts which in turn synthesize large amounts of ECM, mainly collagen, leading to tissue fibrosis and eventually to liver cirrhosis.
Hepatic Fibrosis / Hepatic Stellate Cell Activation Genes list
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A2Malpha-2-macroglobulin ACTA2actin alpha 2, smooth muscle AGTangiotensinogen AGTR1angiotensin II receptor type 1 BAMBIBMP and activin membrane bound inhibitor BAXBCL2 associated X, apoptosis regulator BCL2BCL2 apoptosis regulator CCL2C-C motif chemokine ligand 2 CCL21C-C motif chemokine ligand 21 CCL5C-C motif chemokine ligand 5 CCN2cellular communication network factor 2 CCR5C-C motif chemokine receptor 5 CCR7C-C motif chemokine receptor 7 CD14CD14 molecule CD40CD40 molecule CD40LGCD40 ligand COL1A1collagen type I alpha 1 chain COL1A2collagen type I alpha 2 chain COL3A1collagen type III alpha 1 chain CSF1colony stimulating factor 1 CXCL2C-X-C motif chemokine ligand 2 CXCL8C-X-C motif chemokine ligand 8 CXCL9C-X-C motif chemokine ligand 9 CXCR3C-X-C motif chemokine receptor 3 CYP2E1cytochrome P450 family 2 subfamily E member 1 ECE1endothelin converting enzyme 1 EDN1endothelin 1 EDNRAendothelin receptor type A EDNRBendothelin receptor type B EGFepidermal growth factor EGFRepidermal growth factor receptor FASFas cell surface death receptor FASLGFas ligand FGF1fibroblast growth factor 1 FGF2fibroblast growth factor 2 FGFR1fibroblast growth factor receptor 1 FGFR2fibroblast growth factor receptor 2 FLT1fms related receptor tyrosine kinase 1 FLT4fms related receptor tyrosine kinase 4 FN1fibronectin 1 HGFhepatocyte growth factor ICAM1intercellular adhesion molecule 1 IFNA1interferon alpha 1 IFNAR1interferon alpha and beta receptor subunit 1 IFNAR2interferon alpha and beta receptor subunit 2 IFNGinterferon gamma IFNGR1interferon gamma receptor 1 IFNGR2interferon gamma receptor 2 IGF1insulin like growth factor 1 IGF1Rinsulin like growth factor 1 receptor IGFBP3insulin like growth factor binding protein 3 IGFBP4insulin like growth factor binding protein 4 IGFBP5insulin like growth factor binding protein 5 IL10interleukin 10 IL10RAinterleukin 10 receptor subunit alpha IL18RAPinterleukin 18 receptor accessory protein IL1Ainterleukin 1 alpha IL1Binterleukin 1 beta IL1R1interleukin 1 receptor type 1 IL1R2interleukin 1 receptor type 2 IL1RAPinterleukin 1 receptor accessory protein IL1RAPL1interleukin 1 receptor accessory protein like 1 IL1RAPL2interleukin 1 receptor accessory protein like 2 IL1RL1interleukin 1 receptor like 1 IL1RL2interleukin 1 receptor like 2 IL4interleukin 4 IL4Rinterleukin 4 receptor IL6interleukin 6 IL6Rinterleukin 6 receptor KDRkinase insert domain receptor KLF6Kruppel like factor 6 LAMA1laminin subunit alpha 1 LBPlipopolysaccharide binding protein LEPleptin LEPRleptin receptor LHX2LIM homeobox 2 LY96lymphocyte antigen 96 METMET proto-oncogene, receptor tyrosine kinase MMP1matrix metallopeptidase 1 MMP13matrix metallopeptidase 13 MMP2matrix metallopeptidase 2 MMP9matrix metallopeptidase 9 MYH1myosin heavy chain 1 MYH10myosin heavy chain 10 MYH11myosin heavy chain 11 MYH13myosin heavy chain 13 MYH14myosin heavy chain 14 MYH2myosin heavy chain 2 MYH3myosin heavy chain 3 MYH4myosin heavy chain 4 MYH6myosin heavy chain 6 MYH7myosin heavy chain 7 MYH7Bmyosin heavy chain 7B MYH8myosin heavy chain 8 MYH9myosin heavy chain 9 MYL1myosin light chain 1 MYL2myosin light chain 2 MYL3myosin light chain 3 MYL4myosin light chain 4 MYL5myosin light chain 5 MYL6myosin light chain 6 MYL6Bmyosin light chain 6B MYL7myosin light chain 7 MYL9myosin light chain 9 MYO10myosin X MYO18Amyosin XVIIIA MYO18Bmyosin XVIIIB MYO1Amyosin IA MYO1Hmyosin IH MYO5Cmyosin VC NFKB1nuclear factor kappa B subunit 1 NFKB2nuclear factor kappa B subunit 2 NGFRnerve growth factor receptor PDGFAplatelet derived growth factor subunit A PDGFBplatelet derived growth factor subunit B PDGFCplatelet derived growth factor C PDGFRAplatelet derived growth factor receptor alpha PDGFRBplatelet derived growth factor receptor beta PGFplacental growth factor PROK1prokineticin 1 RELREL proto-oncogene, NF-kB subunit RELARELA proto-oncogene, NF-kB subunit RELBRELB proto-oncogene, NF-kB subunit SERPINE1serpin family E member 1 SMAD2SMAD family member 2 SMAD3SMAD family member 3 SMAD4SMAD family member 4 SMAD7SMAD family member 7 STAT1signal transducer and activator of transcription 1 TGFAtransforming growth factor alpha TGFB1transforming growth factor beta 1 TGFB2transforming growth factor beta 2 TGFB3transforming growth factor beta 3 TGFBR1transforming growth factor beta receptor 1 TGFBR2transforming growth factor beta receptor 2 TIMP1TIMP metallopeptidase inhibitor 1 TIMP2TIMP metallopeptidase inhibitor 2 TLR4toll like receptor 4 TNFtumor necrosis factor TNFRSF11BTNF receptor superfamily member 11b TNFRSF1ATNF receptor superfamily member 1A TNFRSF1BTNF receptor superfamily member 1B VCAM1vascular cell adhesion molecule 1 VEGFAvascular endothelial growth factor A VEGFBvascular endothelial growth factor B VEGFCvascular endothelial growth factor C VEGFDvascular endothelial growth factor D
Products related to Hepatic Fibrosis / Hepatic Stellate Cell Activation
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