Pon1 Gene Summary [Rat]
Enables aryldialkylphosphatase activity. Involved in several processes, including response to fatty acid; response to fluoride; and response to lipopolysaccharide. Located in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); cerebrovascular disease (multiple); eye disease (multiple); glucose metabolism disease (multiple); and hematologic cancer (multiple). Orthologous to human PON1 (paraoxonase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pon1 |
| Official Name | paraoxonase 1 [Source:RGD Symbol;Acc:620062] |
| Ensembl ID | ENSRNOG00000008902 |
| Bio databases IDs | |
| Aliases | paraoxonase 1 |
| Synonyms | A-esterase 1, ESA, MVCD5, PARAOXONASE 1, PON |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pon1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phospholipid binding
- aryldialkylphosphatase
- strictosidine synthase
- phosphatase
- calcium ion binding
- high-density lipoprotein binding
- protein homodimerization
- arylesterase
- enzyme
- lactonohydrolase
Pathways
Biological processes and signaling networks where the Pon1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- myocardial infarction
- thrombosis
- coronary disease
- Alzheimer disease
- colitis
- epithelial cancer
- hepatocellular carcinoma
- liver cancer
- atherosclerosis
role in cell
- cell death
- quantity
- phagocytosis by
- proinflammatory response
- response
- signaling in
- bioactivation in
- volume
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- membrane fraction
- Cytoplasm
- Nucleus
- endoplasmic reticulum membrane
- outer leaflet
- Golgi membrane
- plasma
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pon1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- carboxylic acid catabolic process
- phosphatidylcholine metabolic process
- cholesterol metabolic process
- positive regulation of cholesterol efflux
- negative regulation of plasma lipoprotein particle oxidation
- organophosphate catabolic process
- response to toxin
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- extracellular space
- extracellular vesicular exosome
- high-density lipoprotein particle
- blood microparticle
- spherical high-density lipoprotein particle
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein homodimerization activity
- calcium ion binding
- aryldialkylphosphatase activity
- arylesterase activity
- phospholipid binding