RIPK1 Gene Summary [Human]
This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein plays a role in inflammation and cell death in response to tissue damage, pathogen recognition, and as part of developmental regulation. RIPK1/RIPK3 kinase-mediated necrosis is referred to as necroptosis. Genetic disruption of this gene in mice results in death shortly after birth. [provided by RefSeq, Aug 2017]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | RIPK1 |
| Official Name | receptor interacting serine/threonine kinase 1 [Source:HGNC Symbol;Acc:HGNC:10019] |
| Ensembl ID | ENSG00000137275 |
| Bio databases IDs | |
| Aliases | receptor interacting serine/threonine kinase 1, receptor-interacting protein kinase 1 |
| Synonyms | AIEFL, D330015H01Rik, IMD57, receptor interacting serine/threonine kinase 1, receptor (TNFRSF)-INTERACTING SERINE-THREONINE KINASE 1, Rinp, RIP, RIP1, RIP-I, Ripk1 predicted, TNRF interacting serine threonine kinase |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RIPK1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Death domain
- death receptor binding
- protein serine/threonine kinase
- protein kinase
- protein binding activity, bridging
- enzyme
- Protein kinase domain
- identical protein binding
- PUbS domain
- RXXsL motif
- RIP homotypic interaction motif
- intermediate domain
- Tyrosine kinase, catalytic domain
- ubiquitin protein ligase binding
- Protein kinase (unclassified specificity)
- Protein tyrosine and serine/threonine kinase
- central domain
- protein domain specific binding
- protein binding
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- receptor interacting protein homotypic interaction motif
- binding protein
- Protein Kinases, catalytic domain
- protein homodimerization
- Death Domain Superfamily of protein-protein interaction domains
Pathways
Biological processes and signaling networks where the RIPK1 gene in human plays a role, providing insight into its function and relevance in health or disease.
- Activation of IRF by Cytosolic Pattern Recognition Receptors
- Acute Phase Response Signaling
- Autophagy
- Death Receptor Signaling
- Induction of Apoptosis by HIV1
- Neuroinflammation Signaling Pathway
- NF-κB Activation by Viruses
- NF-κB Signaling
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of RIG1-like Receptors in Antiviral Innate Immunity
- SAPK/JNK Signaling
- TNFR1 Signaling
- TWEAK Signaling
- Type I Diabetes Mellitus Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- chronic kidney disease
- hepatitis
- fibrosis
- neoplasia
- bleeding
- dermatitis
- kyphosis
- glioma
- glioma formation
role in cell
- expression in
- activation in
- phosphorylation in
- proliferation
- formation
- production in
- accumulation in
- induction in
- degradation in
- cellular infiltration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- Nucleus
- Mitochondria
- granules
- cytoplasmic aggregates
- cytosol
- endosomal membrane
- neurites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RIPK1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of ATP:ADP antiporter activity
- positive regulation of programmed cell death
- extrinsic apoptotic signaling pathway
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- protein autophosphorylation
- negative regulation of I-kappaB kinase/NF-kappaB cascade
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of NF-kappaB transcription factor activity
- positive regulation of neuron apoptotic process
- positive regulation of execution phase of apoptosis
- positive regulation of necroptosis
- negative regulation of necroptosis
- response to oxidative stress
- MAPK cascade
- inflammatory response
- programmed necrotic cell death
- necroptosis
- positive regulation of macrophage differentiation
- apoptotic process
- positive regulation of interleukin-6-mediated signaling pathway
- positive regulation of tumor necrosis factor production
- cellular response to tumor necrosis factor
- cellular response to hydrogen peroxide
- intracellular signal transduction
- positive regulation of reactive oxygen species metabolic process
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
- protein catabolic process
- positive regulation of inflammatory response
- positive regulation of interleukin-8 production
- tumor necrosis factor-mediated signaling pathway
- positive regulation of gene expression
- positive regulation of JNK cascade
- negative regulation of apoptotic process
- cellular response to growth factor stimulus
- positive regulation of apoptotic process
- T cell apoptotic process
- positive regulation of protein phosphorylation
- negative regulation of extrinsic apoptotic signaling pathway
- positive regulation of extrinsic apoptotic signaling pathway
- response to tumor necrosis factor
Cellular Component
Where in the cell the gene product is active
- mitochondrion
- cytosol
- receptor complex
- death-inducing signaling complex
- endosome membrane
- macromolecular complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- identical protein binding
- protein homodimerization activity
- ubiquitin protein ligase binding
- protein binding
- signaling adaptor activity
- JUN kinase kinase kinase activity
- protein kinase activity
- death receptor binding
- protein serine/threonine kinase activity
- death domain binding