Glrx2 Gene Summary [Mouse]
Enables protein-disulfide reductase activity. Located in mitochondrion. Is expressed in several structures, including adrenal gland; alimentary system; genitourinary system; nervous system; and respiratory system. Orthologous to human GLRX2 (glutaredoxin 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Glrx2 |
| Official Name | glutaredoxin 2 (thioltransferase) [Source:MGI Symbol;Acc:MGI:1916617] |
| Ensembl ID | ENSMUSG00000018196 |
| Bio databases IDs | |
| Aliases | glutaredoxin 2 (thioltransferase) |
| Synonyms | 1700010P22Rik, AI645710, CGI-133, glutaredoxin 2, GRX2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Glrx2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein disulfide-isomerase
- Glutaredoxin-family domain
- protein disulfide oxidoreductase
- Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
- active site
- arsenate reductase (glutaredoxin)
- enzyme
- protein binding
- glutathione disulfide oxidoreductase
Pathways
Biological processes and signaling networks where the Glrx2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colon epithelial cancer
- colon carcinoma
- cataract disease
role in cell
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- perinuclear region
- Nucleus
- Mitochondria
- mitochondrial matrix
- nucleoplasm
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Glrx2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to redox state
- response to temperature stimulus
- cellular response to superoxide
- DNA protection
- glutathione metabolic process
- apoptotic process
- cell differentiation
- regulation of transcription, DNA-dependent
- cell redox homeostasis
- regulation of signal transduction
Cellular Component
Where in the cell the gene product is active
- dendrite
- nucleus
- mitochondrial matrix
- intracellular membrane-bounded organelle
- mitochondrion
- neuronal cell body
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- glutathione disulfide oxidoreductase activity
- protein disulfide isomerase activity
- protein binding
- protein disulfide oxidoreductase activity
- metal ion binding
- electron carrier activity
- arsenate reductase (glutaredoxin) activity
- 2 iron, 2 sulfur cluster binding