Cubn Gene Summary [Mouse]
Predicted to enable cargo receptor activity; hemoglobin binding activity; and protein homodimerization activity. Acts upstream of or within several processes, including lipoprotein transport; receptor-mediated endocytosis; and response to bacterium. Located in several cellular components, including brush border; clathrin-coated pit; and cytoplasmic vesicle. Is active in microvillus membrane. Is expressed in several structures, including egg cylinder; embryo endoderm; genitourinary system; and midgut. Human ortholog(s) of this gene implicated in coronary artery disease. Orthologous to human CUBN (cubilin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cubn |
| Official Name | cubilin (intrinsic factor-cobalamin receptor) [Source:MGI Symbol;Acc:MGI:1931256] |
| Ensembl ID | ENSMUSG00000026726 |
| Bio databases IDs | |
| Aliases | cubilin (intrinsic factor-cobalamin receptor) |
| Synonyms | cubilin, CUBULIN, D2Wsu88e, GP280, IFCR, IGS, IGS1, intrinsic factor-cobalamin receptor, MGA1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cubn often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cargo receptor activity
- signaling receptor activity
- Human growth factor-like EGF
- protein binding
- identical protein binding
- EGF-like domain
- Family of unknown function (DUF5885)
- EGF_CA
- NPXY motif
- CUB
- protein homodimerization
- EGF domain
- hemoglobin binding
- transmembrane receptor
- Coagulation Factor Xa inhibitory site
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Imerslund-Grasbeck syndrome type 1
- enterocyte cobalamin malabsorption
- colorectal cancer
- hereditary disorder
- chronic benign proteinuria
- albuminuria
- binge eating disorder
- Kawasaki disease
- bipolar I disorder
- pervasive developmental disorder
role in cell
- expression in
- endocytosis by
- binding in
- response
- uptake in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- detergent-soluble membrane fractions
- membrane fraction
- endocytic vesicle membrane
- Cytoplasm
- cell surface
- apical compartment
- perinuclear region
- cellular membrane
- endosomes
- vesicles
- lysosome
- Golgi Apparatus
- Endoplasmic Reticulum
- granules
- endocytic tubules
- cytosol
- apical cytoplasm
- apical cell surfaces
- apical membrane
- lysosomal compartment
- recycling endosomes
- late endosomes
- endocytotic vesicle
- brush border
- clathrin-coated pits
- microvilli
- brush border membrane vesicles
- exosomes
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cubn gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tissue homeostasis
- response to bacterium
- cholesterol metabolic process
- cobalamin metabolic process
- establishment of localization in cell
- cobalamin transport
- receptor-mediated endocytosis
- lipoprotein transport
Cellular Component
Where in the cell the gene product is active
- Golgi apparatus
- receptor complex
- lysosomal lumen
- endoplasmic reticulum
- plasma membrane
- lysosomal membrane
- microvillus membrane
- endocytic vesicle
- endosome
- brush border membrane
- extracellular vesicular exosome
- coated pit
- membrane
- cytosol
- extrinsic to external side of plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein homodimerization activity
- calcium ion binding
- cobalamin binding
- cargo receptor activity
- signaling receptor activity