Rnf7 Gene Summary [Mouse]
Enables ubiquitin protein ligase activity. Involved in proteasome-mediated ubiquitin-dependent protein catabolic process and regulation of neuron migration. Acts upstream of with a negative effect on reelin-mediated signaling pathway. Acts upstream of or within several processes, including apoptotic mitochondrial changes; brain development; and intrinsic apoptotic signaling pathway in response to oxidative stress. Located in cytoplasm and nucleus. Part of Cul5-RING ubiquitin ligase complex. Is expressed in central nervous system; eye; and genitourinary system. Orthologous to human RNF7 (ring finger protein 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rnf7 |
| Official Name | ring finger protein 7 [Source:MGI Symbol;Acc:MGI:1337096] |
| Ensembl ID | ENSMUSG00000051234 |
| Bio databases IDs | |
| Aliases | ring finger protein 7 |
| Synonyms | CKBBP1, Rbx2, ring finger protein 7, ROC2, SAG |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rnf7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NEDD8 ligase
- copper ion binding
- zinc ion binding
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- ubiquitin protein ligase activity
- ubiquitin-like-protein ligase
- enzyme
- Ring finger domain
- protein binding
- RING-H2 zinc finger domain
- Anaphase-promoting complex subunit 11 RING-H2 finger
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- tumorigenesis
- breast cancer
- Alzheimer disease
- systemic lupus erythematosus
- colorectal cancer
- organismal death
role in cell
- phosphorylation in
- invasion by
- migration
- apoptosis
- accumulation in
- proliferation
- degradation in
- growth
- accumulation
- ribociclib resistance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rnf7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to redox state
- protein neddylation
- post-translational protein modification
- protein ubiquitination
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- Cul5-RING ubiquitin ligase complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- copper ion binding
- NEDD8 ligase activity