Il6st Gene Summary [Mouse]
Contributes to interleukin-11 binding activity and interleukin-11 receptor activity. Involved in interleukin-6-mediated signaling pathway; intestinal epithelial cell development; and positive regulation of Notch signaling pathway. Acts upstream of or within several processes, including glycogen metabolic process; positive regulation of astrocyte differentiation; and regulation of Notch signaling pathway. Located in dendrite; external side of plasma membrane; and neuronal cell body. Is expressed in several structures, including alimentary system; brain; early conceptus; hemolymphoid system; and reproductive system. Used to study rheumatoid arthritis and stomach cancer. Human ortholog(s) of this gene implicated in arteriosclerosis; hyper IgE recurrent infection syndrome 4; hyperandrogenism; and immunodeficiency 94. Orthologous to human IL6ST (interleukin 6 cytokine family signal transducer). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Il6st |
| Official Name | interleukin 6 signal transducer [Source:MGI Symbol;Acc:MGI:96560] |
| Ensembl ID | ENSMUSG00000021756 |
| Bio databases IDs | |
| Aliases | interleukin 6 signal transducer |
| Synonyms | 5133400A03Rik, Ac1055, CD130, CDW130, D13Ertd699e, Glycoprotein 130, GP130, HIES4, HIES4A, HIES4B, IL-27R-beta, IL-27R-β, IL-6RB, Il6 transd, IMD94, interleukin 6 cytokine family signal transducer, Interleukin-6 receptor β chain, interleukin 6 signal transducer, Interleukin 6 signal transduction molecule, STWS2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Il6st often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ig-like C2-type domain
- Box motif
- signal peptide
- Fibronectin type 3 domain
- identical protein binding
- cytokine binding homology domain
- Box I domain
- serine-rich region
- interleukin-27 receptor
- Box II domain
- cytoplasmic domain
- interleukin-6 receptor binding
- ligand-binding domain
- oncostatin-M receptor
- immunoglobulin-like protein domain
- intracellular domain
- ciliary neurotrophic factor receptor
- leukemia inhibitory factor receptor
- membrane-proximal domain
- transmembrane receptor
- growth factor binding
- SHP-2 binding domain
- coreceptor
- interleukin-11 receptor
- GTP binding domain
- interleukin-6 receptor
- extracellular domain
- proline-rich box
- ectodomain
- immunoglobulin domain
- Purple acid Phosphatase, N-terminal domain
- YXPQ motif
- protein binding
- acidic domain
- protein tyrosine kinase activator
- phosphotyrosine motif
- fibronectin III-like domain
- cytokine binding module
- dileucine internalization motif
- interleukin-6 binding
- ciliary neurotrophic factor receptor binding
- FN3
- interleukin-11 binding
- transmembrane domain
- immunoglobulin G-like domain
- STAT3 binding domain
- ERK phosphorylation site
- YXXQ motif
Pathways
Biological processes and signaling networks where the Il6st gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Acute Phase Response Signaling
- CNTF Signaling
- Colorectal Cancer Metastasis Signaling
- ERK5 Signaling
- FAK Signaling
- Glucocorticoid Receptor Signaling
- IL-10 Signaling
- IL-12 Signaling and Production in Macrophages
- IL-6 Signaling
- Mouse Embryonic Stem Cell Pluripotency
- Oncostatin M Signaling
- Role of JAK family kinases in IL-6-type Cytokine Signaling
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency
- Role of NFAT in Cardiac Hypertrophy
- STAT3 Pathway
- T Helper Cell Differentiation
- Transcriptional Regulatory Network in Embryonic Stem Cells
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- non-squamous non-small cell lung cancer
- anemia
- cancer
- rheumatoid arthritis
- schizophrenia
- stroke
- schizoaffective disorder
- systemic juvenile idiopathic arthritis
- autosomal recessive hyper-IgE recurrent infection syndrome type 4
phenotypes
- embryonic lethality prior to tooth bud stage
- preweaning lethality complete penetrance
- abnormal B cell physiology
- abnormal Schwann cell morphology
- abnormal T cell activation
- abnormal T cell clonal deletion
- abnormal T cell differentiation
- abnormal action potential
- abnormal astrocyte morphology
- abnormal bone marrow cell morphology/development
- abnormal bone marrow development
- abnormal bone structure
- abnormal channel response intensity
- abnormal common myeloid progenitor cell morphology
- abnormal cortical plate morphology
- abnormal dendritic cell antigen presentation
- abnormal digestive system morphology
- abnormal digestive system physiology
- abnormal embryonic growth/weight/body size
- abnormal erythropoiesis
- abnormal femur morphology
- abnormal heart development
- abnormal heart ventricle morphology
- abnormal immunoglobulin level
- abnormal inflammatory response
- abnormal involution of the mammary gland
- abnormal joint morphology
- abnormal leukocyte cell number
- abnormal long bone diaphysis morphology
- abnormal long bone morphology
- abnormal megakaryocyte morphology
- abnormal myelination
- abnormal myocardial fiber physiology
- abnormal osteoblast physiology
- abnormal osteoclast differentiation
- abnormal osteoclast morphology
- abnormal osteoclast physiology
- abnormal peritoneum morphology
- abnormal skeleton morphology
- abnormal small intestine morphology
- abnormal stomach morphology
- abnormal stomach mucosa morphology
- abnormal synovial joint capsule morphology
- abnormal thrombopoiesis
- abnormal thymocyte activation
- abnormal trabecular bone morphology
- anemia
- bowed femur
- bowed fibula
- bowed humerus
- bowed radius
- bowed tibia
- bowed ulna
- cecum inflammation
- conjunctivitis
- decreased B-1a cell number
- decreased IgA level
- decreased IgG level
- decreased IgG1 level
- decreased IgG2a level
- decreased IgG2b level
- decreased blood urea nitrogen level
- decreased body length
- decreased body size
- decreased body weight
- decreased circulating calcium level
- decreased circulating free fatty acid level
- decreased common myeloid progenitor cell number
- decreased compact bone thickness
- decreased diameter of femur
- decreased double-positive T cell number
- decreased embryo size
- decreased erythroid progenitor cell number
- decreased hematopoietic stem cell number
- decreased immunoglobulin level
- decreased interferon-gamma secretion
- decreased interleukin-4 secretion
- decreased joint mobility
- decreased liver glycogen level
- decreased megakaryocyte cell number
- decreased osteoblast cell number
- decreased physiological sensitivity to xenobiotic
- decreased susceptibility to induced colitis
- decreased thymocyte number
- decreased trabecular bone thickness
- embryonic lethality incomplete penetrance
- enlarged axillary lymph nodes
- enlarged cervical lymph nodes
- enlarged inguinal lymph nodes
- enlarged mesenteric lymph nodes
- enlarged spleen
- enlarged stomach
- failure of embryo implantation
- female infertility
- gastric ulcer
- gastrointestinal hemorrhage
- gastrointestinal ulcer
- increased B cell number
- increased CD4-positive alpha beta T cell number
- increased CD8-positive alpha-beta T cell number
- increased IgA level
- increased IgE level
- increased IgG level
- increased IgG1 level
- increased IgG2a level
- increased IgG2b level
- increased IgM level
- increased activated T cell number
- increased activity of parathyroid
- increased adenoma incidence
- increased anti-double stranded DNA antibody level
- increased anti-nuclear antigen antibody level
- increased anti-single stranded DNA antibody level
- increased autoantibody level
- increased bone mineral content
- increased bone mineral density
- increased bone mineralization
- increased bone ossification
- increased cell proliferation
- increased circulating interleukin-6 level
- increased circulating parathyroid hormone level
- increased double-negative T cell number
- increased heart rate
- increased inflammatory response
- increased interferon-gamma secretion
- increased interleukin-6 secretion
- increased leukocyte cell number
- increased megakaryocyte cell number
- increased neutrophil cell number
- increased nucleated erythrocyte cell number
- increased osteoblast cell number
- increased osteoclast cell number
- increased physiological sensitivity to xenobiotic
- increased sensitivity to xenobiotic induced morbidity/mortality
- increased single-positive T cell number
- increased stomach pH
- increased susceptibility to endotoxin shock
- increased susceptibility to induced arthritis
- increased susceptibility to induced colitis
- increased susceptibility to parasitic infection
- increased trabecular bone thickness
- joint swelling
- lethality during fetal growth through weaning complete penetrance
- lethality throughout fetal growth and development complete penetrance
- lymph node hyperplasia
- neonatal lethality complete penetrance
- no abnormal phenotype detected
- osteoporosis
- postnatal lethality
- postnatal lethality incomplete penetrance
- premature death
- rectal prolapse
- rheumatoid arthritis
- short femur
- short limbs
- shortened RR interval
- spleen hyperplasia
- stomach inflammation
- thin ventricular wall
- thrombocytopenia
- thymus hypoplasia
role in cell
- accumulation
- quantity
- cell death
- proliferation
- growth
- activation
- phosphorylation in
- expression in
- migration
- apoptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- plasma membrane fraction
- caveolae fraction
- detergent-insoluble fractions
- membrane fraction
- synaptosomal membrane fractions
- cell surface
- Extracellular Space
- intracellular membranes
- cellular membrane
- vesicles
- Golgi Apparatus
- apical cell surfaces
- basolateral cell surfaces
- plasma membrane extracellular face
- caveolae
- basolateral membrane
- membrane rafts
- perikaryon
- dendrites
- plasma
- synaptic vesicle fractions
- synaptosomal fractions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Il6st gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to cytokine stimulus
- oncostatin-M-mediated signaling pathway
- interleukin-11-mediated signaling pathway
- positive regulation of cell proliferation
- positive regulation of astrocyte differentiation
- positive regulation of T cell proliferation
- positive regulation of tyrosine phosphorylation of STAT protein
- positive regulation of osteoblast differentiation
- intestinal epithelial cell development
- positive regulation of Notch signaling pathway
- negative regulation of neuron apoptotic process
- positive regulation of acute inflammatory response
- glycogen metabolic process
- positive regulation of adaptive immune response
- leukemia inhibitory factor signaling pathway
- cytokine-mediated signaling pathway
- negative regulation of apoptotic process
- ciliary neurotrophic factor-mediated signaling pathway
- interleukin-6-mediated signaling pathway
- positive regulation of cardiac muscle hypertrophy
- interleukin-27-mediated signaling pathway
- positive regulation vascular endothelial growth factor production
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- receptor complex
- neuronal cell body
- extracellular region
- plasma membrane
- interleukin-6 receptor complex
- dendrite
- extracellular vesicular exosome
- oncostatin-M receptor complex
- ciliary neurotrophic factor receptor complex
- membrane raft
- membrane
Molecular Function
What the gene product does at the molecular level
- interleukin-27 receptor activity
- coreceptor activity
- growth factor binding
- identical protein binding
- cytokine receptor activity
- ciliary neurotrophic factor receptor binding
- interleukin-6 receptor binding
- ciliary neurotrophic factor receptor activity
- scaffold protein binding
- protein binding
- interleukin-11 receptor activity
- oncostatin-M receptor activity
- leukemia inhibitory factor receptor activity
- interleukin-6 receptor activity
- protein tyrosine kinase activator activity
- interleukin-6 binding
- interleukin-11 binding
- cytokine binding