Rag2 Gene Summary [Mouse]
Enables several functions, including methylated histone binding activity; phosphatidylinositol phosphate binding activity; and phosphatidylinositol-3,4-bisphosphate binding activity. Involved in T cell differentiation in thymus; V(D)J recombination; and pre-B cell allelic exclusion. Acts upstream of or within several processes, including B cell homeostatic proliferation; lymphocyte differentiation; and positive regulation of organ growth. Predicted to be located in nucleoplasm. Predicted to be part of DNA recombinase complex. Is expressed in gut; hemolymphoid system; and liver. Used to study Omenn syndrome and severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, Nk cell-positive. Human ortholog(s) of this gene implicated in Omenn syndrome; combined cellular and humoral immune defects with granulomas; severe combined immunodeficiency; and severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, Nk cell-positive. Orthologous to human RAG2 (recombination activating 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rag2 |
| Official Name | recombination activating gene 2 [Source:MGI Symbol;Acc:MGI:97849] |
| Ensembl ID | ENSMUSG00000032864 |
| Bio databases IDs | |
| Aliases | recombination activating gene 2 |
| Synonyms | recombination activating 2, recombination activating gene 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rag2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- Recombination activating protein 2
- protein binding activity, bridging
- chromatin binding
- enzyme
- protein binding
- core domain, functional
- phosphatidylinositol binding
- binding protein
- zinc ion binding
- phosphatidylinositol-3,4,5-triphosphate binding
- phosphatidylinositol-4,5-bisphosphate binding
- PHD finger superfamily
Pathways
Biological processes and signaling networks where the Rag2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- epithelial cancer
- diarrhea
- infection
- colitis
- breast cancer
- bleeding
- bacteremia
- dextran sodium sulfate-induced colitis
phenotypes
- abnormal B cell differentiation
- abnormal B cell morphology
- abnormal B cell number
- abnormal B cell physiology
- abnormal Peyer's patch morphology
- abnormal T cell morphology
- abnormal T cell receptor V(D)J recombination
- abnormal T-helper 1 physiology
- abnormal chemokine secretion
- abnormal digestive system morphology
- abnormal double-negative T cell morphology
- abnormal double-positive T cell morphology
- abnormal effector T cell morphology
- abnormal gamma-delta T cell differentiation
- abnormal humoral immune response
- abnormal immune system cell morphology
- abnormal immune system organ morphology
- abnormal immunoglobulin V(D)J recombination
- abnormal interferon secretion
- abnormal intestinal epithelium morphology
- abnormal intestinal mucosa morphology
- abnormal lymph node morphology
- abnormal lymphocyte physiology
- abnormal lymphopoiesis
- abnormal macrophage physiology
- abnormal pre-B cell morphology
- abnormal response to transplant
- abnormal spleen morphology
- abnormal stomach mucosa morphology
- abnormal thymus morphology
- absent Hassall's corpuscle
- absent Peyer's patches
- absent mature B cells
- alopecia
- arrested B cell differentiation
- arrested T cell differentiation
- cachexia
- colitis
- decreased B cell number
- decreased CD4-positive alpha beta T cell number
- decreased CD8-positive alpha-beta T cell number
- decreased IgA level
- decreased IgG level
- decreased IgM level
- decreased NK T cell number
- decreased T cell number
- decreased T cell proliferation
- decreased body size
- decreased bone marrow cell number
- decreased double-negative T cell number
- decreased double-positive T cell number
- decreased immature B cell number
- decreased lymphocyte cell number
- decreased mature B cell number
- decreased monocyte cell number
- decreased pre-B cell number
- decreased spleen white pulp amount
- decreased susceptibility to bacterial infection induced morbidity/mortality
- decreased susceptibility to parasitic infection
- decreased susceptibility to type IV hypersensitivity reaction
- decreased thymocyte number
- erythroderma
- increased DN3 thymocyte number
- increased double-negative T cell number
- increased granulocyte number
- increased immature B cell number
- increased macrophage cell number
- increased natural killer cell mediated cytotoxicity
- increased susceptibility to bacterial infection
- increased susceptibility to infection
- lung inflammation
- lymph node hypoplasia
- no abnormal phenotype detected
- small cervical lymph nodes
- small inguinal lymph nodes
- small lymph nodes
- small spleen
- spleen hypoplasia
- thymus hypoplasia
role in cell
- cell death
- differentiation
- expression in
- proliferation
- apoptosis
- number
- binding in
- production in
- quantity
- segregation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rag2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- V(D)J recombination
- negative regulation of T cell differentiation in thymus
- organ growth
- B cell differentiation
- T cell differentiation in thymus
- positive regulation of organ growth
- T cell lineage commitment
- chromatin organization
- defense response to bacterium
- pre-B cell allelic exclusion
- mature B cell differentiation involved in immune response
- B cell homeostatic proliferation
- B cell lineage commitment
Cellular Component
Where in the cell the gene product is active
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol-3,4,5-trisphosphate binding
- phosphatidylinositol-4,5-bisphosphate binding
- zinc ion binding
- methylated histone residue binding
- phosphatidylinositol binding
- phosphatidylinositol-3,5-bisphosphate binding
- sequence-specific DNA binding
- chromatin binding
- phosphatidylinositol-3,4-bisphosphate binding