PPIA Gene Summary [Human]
This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The encoded protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported. [provided by RefSeq, Jul 2008]
Details
| Type | Retained Intron |
| Official Symbol | PPIA |
| Official Name | peptidylprolyl isomerase A [Source:HGNC Symbol;Acc:HGNC:9253] |
| Ensembl ID | ENSG00000196262 |
| Bio databases IDs | |
| Aliases | peptidylprolyl isomerase A, cyclophilin A, Peptidyl-prolyl cis-trans isomerase A |
| Synonyms | Cphn, CYCA, Cyclophilin, CYCLOPHILIN A, Cyclophillin, CyP-18, CYPA, CYPH, HEL-S-69p, LOC100503444, p1B15, p31, PEPTIDYL-PROLYL CIS-TRANS ISOMERASE, peptidylprolyl isomerase A, SP18, T-Cell Cyclophilin |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PPIA often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- peptidylprolyl isomerase
- Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
- cyclophilin
- integrin binding
- cyclosporin A binding
- active site
- enzyme
- protein binding
- glycosaminoglycan binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- allergic conjunctivitis
- neoplasia
- insulin-dependent diabetes mellitus
- rheumatoid arthritis
- cardiovascular disorder
- acute myocardial infarction
- end stage renal disease
- renal failure
- chronic renal failure
- keratitis
role in cell
- phosphorylation in
- proliferation
- quantity
- number
- cell death
- formation
- expression in
- survival
- activation in
- apoptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- secretory granule lumen
- ficolin-1-rich granule lumen
- cell surface
- Extracellular Space
- Nucleus
- endosomes
- Mitochondria
- cytosol
- nucleoli
- acrosome
- synaptic vesicles
- early endosomes
- exosomes
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PPIA gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- endothelial cell activation
- regulation of viral genome replication
- protein peptidyl-prolyl isomerization
- positive regulation of NF-kappaB transcription factor activity
- negative regulation of protein kinase activity
- apoptotic process
- lipid particle organization
- positive regulation of protein secretion
- positive regulation of viral genome replication
- platelet aggregation
- platelet activation
- activation of protein kinase B activity
- cell adhesion molecule production
- neuron differentiation
- positive regulation of MAPK cascade
- protein folding
- release of virus from host
- negative regulation of protein phosphorylation
- positive regulation of protein phosphorylation
- cellular response to oxidative stress
- neutrophil chemotaxis
- negative regulation of stress-activated MAPK cascade
- positive regulation of protein dephosphorylation
- leukocyte chemotaxis
- regulation of apoptotic signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular space
- extracellular vesicular exosome
- focal adhesion
- cytoplasm
- membrane
- vesicle
- cytosol
- macromolecular complex
- secretory granule lumen
- extracellular region
Molecular Function
What the gene product does at the molecular level
- cyclosporin A binding
- virion binding
- peptidyl-prolyl cis-trans isomerase activity
- RNA binding
- protein binding
- integrin binding
- unfolded protein binding