Brd3 Gene Summary [Rat]
Predicted to enable several functions, including lncRNA binding activity; lysine-acetylated histone binding activity; and molecular condensate scaffold activity. Predicted to be involved in several processes, including endodermal cell differentiation; positive regulation of transcription by RNA polymerase II; and protein localization to chromatin. Predicted to be active in chromatin and nucleus. Orthologous to human BRD3 (bromodomain containing 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Brd3 |
| Official Name | bromodomain containing 3 [Source:RGD Symbol;Acc:1308925] |
| Ensembl ID | ENSRNOG00000007681 |
| Bio databases IDs | |
| Aliases | bromodomain containing 3 |
| Synonyms | 2410084F24Rik, bromodomain containing 3, FSHRG2, Fsrg2, KIAA0043, ORFX, RING3L, RINGL3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Brd3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- protein serine/threonine kinase
- histone binding
- degron
- protein binding activity, bridging
- chromatin binding
- protein binding
- extraterminal domain
- Bromodomain extra-terminal - transcription regulation
- Bromodomain
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- diabetes mellitus
- colorectal cancer
- schizophrenia
- familial colorectal cancer
- tinnitus
role in cell
- activation in
- transcription in
- binding in
- differentiation
- ubiquitination in
- degradation in
- homologous recombination repair in
- inflammatory response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Brd3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein localization to chromatin
- endodermal cell differentiation
- chromatin organization
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- protein binding
- histone acetyl-lysine binding
- chromatin binding