Fcnb Gene Summary [Rat]
Predicted to enable several functions, including antigen binding activity; pattern recognition receptor activity; and sialic acid binding activity. Predicted to be involved in several processes, including activation of immune response; positive regulation of interleukin-8 production; and positive regulation of opsonization. Predicted to be located in plasma membrane. Predicted to be part of serine-type endopeptidase complex. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Orthologous to several human genes including FCN1 (ficolin 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fcnb |
| Official Name | ficolin B [Source:RGD Symbol;Acc:621222] |
| Ensembl ID | ENSRNOG00000009342 |
| Bio databases IDs | |
| Aliases | ficolin B |
| Synonyms | Fcn2, Fcnb, FCNM, ficolin 1, Ficolin b, M-FICOLIN |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Fcnb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- calcium-dependent protein binding
- signaling receptor activity
- binding protein
- G-protein-coupled receptor binding
- antigen binding
- Collagen triple helix repeat (20 copies)
- protein binding
- polysaccharide binding
- identical protein binding
- FReD
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rheumatoid arthritis
- abdominal aortic aneurysm
- diabetic nephropathy
- androgenic alopecia
- infection by bacteria
role in cell
- phagocytosis
- production in
- infiltration by
- phagocytosis by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- secretory granule lumen
- ficolin-1-rich granule lumen
- Plasma Membrane
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Fcnb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell surface pattern recognition receptor signaling pathway
- protein localization at cell surface
- positive regulation of interleukin-8 production
- G-protein coupled receptor signaling pathway
- negative regulation of viral entry into host cell
- complement activation, lectin pathway
- proteolysis
- recognition of apoptotic cell
Cellular Component
Where in the cell the gene product is active
- extracellular space
- collagen
- external side of plasma membrane
- secretory granule lumen
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor binding
- protein binding
- antigen binding
- metal ion binding
- sialic acid binding
- carbohydrate binding
- receptor binding