Pkm Gene Summary [Rat]
Enables several functions, including ADP binding activity; pyruvate kinase activity; and thyroid hormone binding activity. Involved in several processes, including monocarboxylic acid metabolic process; protein homotetramerization; and response to insulin. Part of pyruvate kinase complex. Biomarker of hypertension. Orthologous to human PKM (pyruvate kinase M1/2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pkm |
| Official Name | pyruvate kinase M1/2 [Source:RGD Symbol;Acc:3337] |
| Ensembl ID | ENSRNOG00000011329 |
| Bio databases IDs | |
| Aliases | pyruvate kinase M1/2 |
| Synonyms | AC160637.1, CTHBP, HEL-S-30, OIP3, p58, PK, PK3, PKM12, PKM1/2, PKM/2, Pyruvate kinase 3, Pyruvate kinase M, pyruvate kinase M1/2, pyruvate kinase, muscle, TCB, THBP1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pkm often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein dimerization
- hormone binding
- protein serine/threonine kinase
- protein kinase
- transcription co-activator
- mRNA binding
- ADP binding
- nuclear localization sequence
- protein binding
- enzyme
- protein-tyrosine kinase
- identical protein binding
- phosphorylation site
- kinase
- Pyruvate_Kinase
- protein homodimerization
- pyruvate kinase
- Pyruvate kinase, alpha/beta domain
Pathways
Biological processes and signaling networks where the Pkm gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- liver cancer
- epithelial cancer
- epithelial neoplasia
- cancer
- liver neoplasia
- digestive system cancer
- abdominal cancer
- diffuse large B-cell lymphoma
- lung cancer
role in cell
- expression in
- number
- replication in
- phosphorylation in
- upregulation in
- production in
- synthesis in
- size
- formation
- formation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- intracellular membrane-bounded organelle
- secretory granule lumen
- ficolin-1-rich granule lumen
- cilia
- Extracellular Space
- perinuclear region
- cellular membrane
- Nucleus
- cytosol
- rough endoplasmatic reticulum
- kinetochores
- chromatin
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pkm gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to insulin stimulus
- positive regulation of cytoplasmic translation
- glycolysis
- programmed cell death
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- cytoplasm
- mitochondrion
- cilium
- rough endoplasmic reticulum
- vesicle
- cytosol
- secretory granule lumen
- extracellular region
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- ATP binding
- pyruvate kinase activity
- protein tyrosine kinase activity
- protein binding
- RNA binding
- potassium ion binding
- cadherin binding
- mRNA binding
- MHC class II protein complex binding