Ube2k Gene Summary [Rat]
Predicted to enable ubiquitin conjugating enzyme activity; ubiquitin protein ligase binding activity; and ubiquitin-ubiquitin ligase activity. Acts upstream of or within intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress. Predicted to be located in cytoplasm and filopodium tip. Predicted to be active in nucleus. Orthologous to human UBE2K (ubiquitin conjugating enzyme E2 K). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ube2k |
| Official Name | ubiquitin-conjugating enzyme E2K [Source:RGD Symbol;Acc:1311626] |
| Ensembl ID | ENSRNOG00000027088 |
| Bio databases IDs | |
| Aliases | ubiquitin-conjugating enzyme E2K |
| Synonyms | D5Ertd601e, E2-25K, HIP-2, HYPG, LIG, UBC1, UBIQUITIN CARRIER, ubiquitin-conjugating enzyme E2K |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ube2k often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- UBA domain-like superfamily
- core domain, structural
- ubiquitin protein ligase binding
- Ubiquitin-conjugating enzyme
- ubiquitin conjugating enzyme
- transcription regulator
- catalytic domain
- ubiquitin protein ligase activity
- ubiquitin-protein transferase activity
- UBCc_UEV
- protein binding
Pathways
Biological processes and signaling networks where the Ube2k gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- cold thyroid nodule
- preeclampsia
- mumps
- carbon tetrachloride-induced liver fibrosis
- psoriasis
role in cell
- expression in
- cell death
- proliferation
- activation
- aggregation in
- activity
- amyloid beta 42 resistance
- endoplasmic reticulum-associated degradation in
- stabilization in
- dissociation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- filopodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ube2k gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein K48-linked ubiquitination
- protein polyubiquitination
- positive regulation of type I interferon-mediated signaling pathway
- positive regulation of peptidyl-threonine phosphorylation
- free ubiquitin chain polymerization
- regulation of proteasomal ubiquitin-dependent protein catabolic process
- cellular response to interferon-beta
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- filopodium tip
Molecular Function
What the gene product does at the molecular level
- ATP binding
- ubiquitin-protein ligase activity
- protein binding
- ubiquitin protein ligase binding
- ubiquitin-ubiquitin ligase activity