VRK2 Gene Summary [Human]
This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. The encoded protein acts as an effector of signaling pathways that regulate apoptosis and tumor cell growth. Variants in this gene have been associated with schizophrenia. Alternative splicing results in multiple transcript variants that differ in their subcellular localization and biological activity. [provided by RefSeq, Jan 2014]
Details
| Type | Protein Coding |
| Official Symbol | VRK2 |
| Official Name | VRK serine/threonine kinase 2 [Source:HGNC Symbol;Acc:HGNC:12719] |
| Ensembl ID | ENSG00000028116 |
| Bio databases IDs | |
| Aliases | VRK serine/threonine kinase 2 |
| Synonyms | 2810003O05Rik, LOC101927261, vaccinia related kinase 2, VRK serine/threonine kinase 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human VRK2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- protein serine/threonine kinase
- protein kinase
- protein kinase binding
- Protein Kinases, catalytic domain
- protein domain specific binding
- protein binding
Pathways
Biological processes and signaling networks where the VRK2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- major depression
- prostate cancer
- neuroticism
- schizophrenia
- opioid-related disorder
- depressive disorder
- generalized epilepsy
- gastric carcinoma
- gastric epithelial cancer
role in cell
- phosphorylation in
- expression in
- growth
- activation in
- binding in
- transcription in
- invasion
- tumorigenicity
- response by
- sphere formation by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cellular membrane
- Endoplasmic Reticulum
- cytosol
- endoplasmic reticulum membrane
- mitochondrial membrane
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human VRK2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of MAPK cascade
- signal transduction
- regulation of interleukin-1-mediated signaling pathway
- protein autophosphorylation
- cellular response to oxidative stress
- peptidyl-serine phosphorylation
- protein phosphorylation
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- endoplasmic reticulum membrane
- nucleus
- mitochondrial membrane
- cytoplasm
- macromolecular complex
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein kinase binding
- protein domain specific binding
- protein binding
- protein serine/threonine kinase activity