LCP2 Gene Summary [Human]
This gene encodes an adapter protein that acts as a substrate of the T cell antigen receptor (TCR)-activated protein tyrosine kinase pathway. The encoded protein associates with growth factor receptor bound protein 2, and is thought to play a role TCR-mediated intracellular signal transduction. A similar protein in mouse plays a role in normal T-cell development and activation. Mice lacking this gene show subcutaneous and intraperitoneal fetal hemorrhaging, dysfunctional platelets and impaired viability. [provided by RefSeq, Nov 2016]
Details
| Type | Protein Coding |
| Official Symbol | LCP2 |
| Official Name | lymphocyte cytosolic protein 2 [Source:HGNC Symbol;Acc:HGNC:6529] |
| Ensembl ID | ENSG00000043462 |
| Bio databases IDs | |
| Aliases | lymphocyte cytosolic protein 2, 76 kDa tyrosine phosphoprotein, SH2 domain-containing leukocyte protein of 76kD |
| Synonyms | IMD81, Lymphocyte cytosolic protein 2, m1Khoe, SLP-76, twm |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LCP2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- gads binding domain
- Sterile alpha motif
- RXXK motif
- SAM (Sterile alpha motif )
- SAM domain (Sterile alpha motif)
- Src homology 2 (SH2) domain
- protein binding
- proline rich domain
- extreme C-terminal domain
- tyrosine phosphorylation site
- Grb2 binding domain
- phosphorylation site
Pathways
Biological processes and signaling networks where the LCP2 gene in human plays a role, providing insight into its function and relevance in health or disease.
- CD28 Signaling in T Helper Cells
- CTLA4 Signaling in Cytotoxic T Lymphocytes
- Fc Epsilon RI Signaling
- Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes
- G Protein Signaling Mediated by Tubby
- GP6 Signaling Pathway
- iCOS-iCOSL Signaling in T Helper Cells
- Natural Killer Cell Signaling
- PKCθ Signaling in T Lymphocytes
- Role of NFAT in Regulation of the Immune Response
- T Cell Receptor Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- bleeding
- infection by HIV-1
- immunodeficiency 81
- contact dermatitis
- renal clear cell adenocarcinoma
- renal clear cell cancer
- acute kidney injury
- ventricular tachycardia
- anaphylaxis
- experimental autoimmune encephalomyelitis
role in cell
- quantity
- expression in
- activation in
- cellular infiltration by
- production in
- phosphorylation in
- proliferation
- signaling in
- growth
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- raft fractions
- perinuclear region
- Nucleus
- intercellular junctions
- cytosol
- membrane rafts
- phagosomes
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LCP2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- immune response
- positive regulation of protein kinase activity
- transmembrane receptor protein tyrosine kinase signaling pathway
- mast cell activation
- intracellular signal transduction
- T cell receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- cell-cell junction
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding