MAP4K4 Gene Summary [Human]
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | MAP4K4 |
| Official Name | mitogen-activated protein kinase kinase kinase kinase 4 [Source:HGNC Symbol;Acc:HGNC:6866] |
| Ensembl ID | ENSG00000071054 |
| Bio databases IDs | |
| Aliases | mitogen-activated protein kinase kinase kinase kinase 4, HPK/GCK-like kinase, hepatocyte progenitor kinase-like/germinal center kinase-like kinase |
| Synonyms | 9430080K19RIK, FLH21957, FLJ20373, haemoPOIETIC PROGENITOR KINASE, HEL-S-31, HEMOPOIETIC PROGENITOR KINASE, HGK, MEKKK4, mitogen-activated protein kinase kinase kinase kinase 4, NIK |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MAP4K4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- leucine rich domain
- Protein kinase (unclassified specificity)
- regulatory domain
- Protein tyrosine and serine/threonine kinase
- CNH domain
- ATP binding
- protein binding
- Protein kinase domain
- Sh3 domain binding motif
- kinase
- germinal center kinase homology domain
- Serine/Threonine protein kinases, catalytic domain
- microtubule binding
- kinase domain
- Protein Kinases, catalytic domain
- MAP kinase kinase kinase kinase
- creatine kinase
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the MAP4K4 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- peripheral arterial disease
- cancer
- asthma
- colorectal cancer
- rheumatoid arthritis
- Alzheimer disease
- non-small cell lung cancer
- lung cancer
- organismal death
- pancreatic ductal adenocarcinoma
role in cell
- survival
- phosphorylation in
- apoptosis
- growth
- cell death
- expression in
- proliferation
- adhesion
- activation in
- invasion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- focal adhesions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MAP4K4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of MAPK cascade
- positive regulation of hippo signaling cascade
- neuron projection morphogenesis
- protein phosphorylation
- positive regulation of GTPase activity
- regulation of JNK cascade
- MAPK cascade
- positive regulation of focal adhesion assembly
- negative regulation of cell-matrix adhesion
- negative regulation of apoptotic process
- microvillus assembly
- positive regulation of ARF protein signal transduction
- positive regulation of keratinocyte migration
- intracellular signal transduction
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- focal adhesion
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- creatine kinase activity
- protein serine/threonine kinase activity
- MAP kinase kinase kinase kinase activity
- microtubule binding