Lpgat1 Gene Summary [Mouse]
Enables 2-acylglycerol O-acyltransferase activity; 2-acylglycerophosphocholine O-acyltransferase activity; and lysophosphatidylethanolamine acyltransferase activity. Involved in phosphatidylethanolamine acyl-chain remodeling and triglyceride biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum. Is expressed in nervous system; nose; respiratory system; salivary gland; and urinary system. Orthologous to human LPGAT1 (lysophosphatidylglycerol acyltransferase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lpgat1 |
| Official Name | lysophosphatidylglycerol acyltransferase 1 [Source:MGI Symbol;Acc:MGI:2446186] |
| Ensembl ID | ENSMUSG00000026623 |
| Bio databases IDs | |
| Aliases | lysophosphatidylglycerol acyltransferase 1 |
| Synonyms | AW112037, FAM34A, FAM34A1, KIAA0205, LOC683760, LPLAT7, lysophosphatidylglycerol acyltransferase 1, NET8 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lpgat1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis
- 1-acylglycerol-3-phosphate O-acyltransferase
- 2-acylglycerol O-acyltransferase
- 2-acylglycerophosphocholine O-acyltransferase
- 2-acylglycerol-3-phosphate O-acyltransferase
- enzyme
- Acyltransferase
- Non-amino-acyl group acyltransferase
- Acyltransferase C-terminus
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- major depression
- cleft lip
regulates
- cholesterol
- triacylglycerol
- phosphatidylserine
- phosphatidylcholine
- 18:0/20:4 phosphatidylethanolamine
- 16:0/20:4 phosphatidylcholine
- 18:0/18:2 phosphatidylethanolamine
- 18:0-18:2 phosphatidylcholine
- fatty acid
- 1-18:0-2-20:4 dimethylphosphatidylethanolamine
role in cell
- synthesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microsomal fraction
- perinuclear region
- cellular membrane
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lpgat1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- phosphatidylethanolamine acyl-chain remodeling
- triglyceride biosynthetic process
- phospholipid biosynthetic process
- phosphatidylglycerol acyl-chain remodeling
- phosphatidylinositol acyl-chain remodeling
- positive regulation of fatty acid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- cytoplasm
- membrane
- endomembrane system
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- 1-acylglycerol-3-phosphate O-acyltransferase activity
- lysophospholipid acyltransferase activity
- transferase activity, transferring acyl groups
- lysophosphatidylethanolamine acyltransferase activity
- 2-acylglycerol O-acyltransferase activity
- 2-acylglycerol-3-phosphate O-acyltransferase activity
- 2-acylglycerophosphocholine O-acyltransferase activity