IL-15 Production
Interleukin 15 (IL-15) belongs to the 4-α-helix bundle family of glycoprotein cytokines that include IL-2, IL-3, IL-4 and IL-21. It exerts profounds effects on the proliferation, survival and differentiation of NK cells and T cells. IL-15 is produced in a variety of cell types like monocytes, dendritic cells, macrophages, keratinocytes, fibroblasts, and nerve cells. Its production is under complex control with regulation occurring at the level of transcription, translation, intracellular trafficking and translocation. (Upgraded 01/2020)...
Pathway Summary
Interleukin 15 (IL-15) belongs to the 4-α-helix bundle family of glycoprotein cytokines that include IL-2, IL-3, IL-4 and IL-21. It exerts profounds effects on the proliferation, survival and differentiation of NK cells and T cells. IL-15 is produced in a variety of cell types like monocytes, dendritic cells, macrophages, keratinocytes, fibroblasts, and nerve cells. Its production is under complex control with regulation occurring at the level of transcription, translation, intracellular trafficking and translocation. (Upgraded 01/2020)
IL-15 Production Genes list
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AATKapoptosis associated tyrosine kinase ABL1ABL proto-oncogene 1, non-receptor tyrosine kinase ABL2ABL proto-oncogene 2, non-receptor tyrosine kinase ALKALK receptor tyrosine kinase AXLAXL receptor tyrosine kinase BLKBLK proto-oncogene, Src family tyrosine kinase BMXBMX non-receptor tyrosine kinase BTKBruton tyrosine kinase CLK1CDC like kinase 1 CLK2CDC like kinase 2 CLK3CDC like kinase 3 CLK4CDC like kinase 4 CSF1Rcolony stimulating factor 1 receptor CSF2RAcolony stimulating factor 2 receptor subunit alpha CSKC-terminal Src kinase DDR1discoidin domain receptor tyrosine kinase 1 DDR2discoidin domain receptor tyrosine kinase 2 DSTYKdual serine/threonine and tyrosine protein kinase DYRK1Adual specificity tyrosine phosphorylation regulated kinase 1A DYRK3dual specificity tyrosine phosphorylation regulated kinase 3 DYRK4dual specificity tyrosine phosphorylation regulated kinase 4 EGFRepidermal growth factor receptor EPHA1EPH receptor A1 EPHA2EPH receptor A2 EPHA3EPH receptor A3 EPHA4EPH receptor A4 EPHA5EPH receptor A5 EPHA6EPH receptor A6 EPHA8EPH receptor A8 EPHB1EPH receptor B1 EPHB2EPH receptor B2 EPHB3EPH receptor B3 EPHB4EPH receptor B4 ERBB2erb-b2 receptor tyrosine kinase 2 ERBB3erb-b2 receptor tyrosine kinase 3 ERBB4erb-b2 receptor tyrosine kinase 4 FERFER tyrosine kinase FESFES proto-oncogene, tyrosine kinase FGFR1fibroblast growth factor receptor 1 FGFR2fibroblast growth factor receptor 2 FGFR3fibroblast growth factor receptor 3 FGFR4fibroblast growth factor receptor 4 FGRFGR proto-oncogene, Src family tyrosine kinase FLT1fms related receptor tyrosine kinase 1 FLT3LGfms related receptor tyrosine kinase 3 ligand FLT4fms related receptor tyrosine kinase 4 FRKfyn related Src family tyrosine kinase FYNFYN proto-oncogene, Src family tyrosine kinase HCKHCK proto-oncogene, Src family tyrosine kinase IFNA21interferon alpha 21 IFNA5interferon alpha 5 IFNB1interferon beta 1 IGF1Rinsulin like growth factor 1 receptor IL15interleukin 15 IL6interleukin 6 INSRinsulin receptor IRF1interferon regulatory factor 1 IRF3interferon regulatory factor 3 ITKIL2 inducible T cell kinase JAK1Janus kinase 1 JAK2Janus kinase 2 JAK3Janus kinase 3 KDRkinase insert domain receptor KITKIT proto-oncogene, receptor tyrosine kinase LCKLCK proto-oncogene, Src family tyrosine kinase LMTK2lemur tyrosine kinase 2 LMTK3lemur tyrosine kinase 3 LTKleukocyte receptor tyrosine kinase LYNLYN proto-oncogene, Src family tyrosine kinase MAP2K1mitogen-activated protein kinase kinase 1 MAP2K3mitogen-activated protein kinase kinase 3 MAP2K4mitogen-activated protein kinase kinase 4 MAP2K5mitogen-activated protein kinase kinase 5 MAP2K6mitogen-activated protein kinase kinase 6 MAP2K7mitogen-activated protein kinase kinase 7 MAP3K11mitogen-activated protein kinase kinase kinase 11 MATKmegakaryocyte-associated tyrosine kinase MERTKMER proto-oncogene, tyrosine kinase METMET proto-oncogene, receptor tyrosine kinase MST1Rmacrophage stimulating 1 receptor MUSKmuscle associated receptor tyrosine kinase NFKB1nuclear factor kappa B subunit 1 NFKB2nuclear factor kappa B subunit 2 NTRK1neurotrophic receptor tyrosine kinase 1 NTRK2neurotrophic receptor tyrosine kinase 2 NTRK3neurotrophic receptor tyrosine kinase 3 PDGFRAplatelet derived growth factor receptor alpha PDGFRBplatelet derived growth factor receptor beta PEAK1pseudopodium enriched atypical kinase 1 PRKCIprotein kinase C iota PRKCZprotein kinase C zeta PTK2protein tyrosine kinase 2 PTK2Bprotein tyrosine kinase 2 beta PTK6protein tyrosine kinase 6 PTK7protein tyrosine kinase 7 (inactive) RELREL proto-oncogene, NF-kB subunit RELARELA proto-oncogene, NF-kB subunit RELBRELB proto-oncogene, NF-kB subunit RETret proto-oncogene ROR1receptor tyrosine kinase like orphan receptor 1 ROR2receptor tyrosine kinase like orphan receptor 2 ROS1ROS proto-oncogene 1, receptor tyrosine kinase RYKreceptor like tyrosine kinase SRCSRC proto-oncogene, non-receptor tyrosine kinase SRMSsrc-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites STAT1signal transducer and activator of transcription 1 STYK1serine/threonine/tyrosine kinase 1 SYKspleen associated tyrosine kinase TECtec protein tyrosine kinase TEKTEK receptor tyrosine kinase TIE1tyrosine kinase with immunoglobulin like and EGF like domains 1 TNK1tyrosine kinase non receptor 1 TNK2tyrosine kinase non receptor 2 TWF1twinfilin actin binding protein 1 TXKTXK tyrosine kinase TYK2tyrosine kinase 2 TYRO3TYRO3 protein tyrosine kinase YES1YES proto-oncogene 1, Src family tyrosine kinase ZAP70zeta chain of T cell receptor associated protein kinase 70
Products related to IL-15 Production
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