Target List
Induction of Apoptosis
Death Domain Receptors
craddfaddtnfb
DNA Damage & Repair
abl1cidebtp53tp63tp73
Extracellular Apoptotic Signals
cflaradapk1
Other Pro-Apoptotic Genes
badb (BAD)baxb (BAX)bcl10bcl2l11bida (BID)bikbnip1a (BNIP1)bnip3bnip3lb (BNIP3L)boka (BOK)casp2casp3acasp6casp8caspa (CASP4)caspb (CASP4)caspblcaspxacd27cycsa (CYCS)dffadffbdiabloa (DIABLO)fasfaslggadd45aa (GADD45A)gadd45ab (GADD45A)ltanod1pycardtnfrsf9b (TNFRSF9)tnfrsfatnfsf10tp53bp2a (TP53BP2)traddtraf3
Anti-Apoptotic
akt1api5bag1bag3baxb (BAX)bcl2abcl2l1birc5a (BIRC5)birc6bnip1a (BNIP1)bnip2bnip3bnip3lb (BNIP3L)brafcd27cd40lgcflaradad1dapk1faima (FAIM)fasigf1rb (IGF1R)il10mcl1a (MCL1)nfkb1ripk2tnfbtp63xiap
Regulation of Apoptosis
Negative Regulation of Apoptosis
bag1bag3bcl10bcl2abcl2l1birc2birc6bnip1a (BNIP1)bnip2bnip3bnip3lb (BNIP3L)brafcasp3acd27cd40lgcflaradapk1dffafasigf1rb (IGF1R)mcl1a (MCL1)tp53tp73xiap
Positive Regulation of Apoptosis
abl1akt1badb (BAD)baxb (BAX)bcl2l11bida (BID)bikbnip3bnip3lb (BNIP3L)casp2casp6casp8caspa (CASP4)caspb (CASP4)caspblcaspxacd40cidebcraddfaddfaslgltanod1pycardripk2tnfbtnfrsf9b (TNFRSF9)tnfrsfatnfsf10tnfsf12tp53tp53bp2a (TP53BP2)traddtraf1traf2atraf3
Death Domain Receptors
cradddapk1faddripk1l (RIPK1)tnfrsf11atnfrsf11btnfrsf13btnfrsf17tnfrsf18tnfrsf19tnfrsf1atnfrsf1btnfrsf21tnfrsfatradd
Caspases & Regulators
Caspases
casp2casp3acasp6casp7casp8casp9caspa (CASP4)caspb (CASP4)caspblcaspxacflaracraddpycard
Caspase Activation
aifm1apaf1baxb (BAX)casp9nod1pycardtnfrsfatp53
Caspase Inhibition
cd27xiap