Target List
Adenocarcinomas
APC, ARID1A, ATM, AXIN2, BARD1, BAX, BMPR1A (ALK3), BRAF, BRCA1, BRCA2, BRIP1, BUB1, BUB1B, CDK12, CDKN2A (P16INK4A), CHEK1, CHEK2 (RAD53), CTNNB1, DCC, DLC1, EGFR (ERBB1), EP300, ERBB2 (HER-2, NEU), ERBB3, ESR1 (ERα), FANCL, FBXW7, FGFR1, FGFR3, FLCN, GNAS, HRAS, KIT (CD117), KRAS, MAP2K1, MCC, MET, MLH1, MLH3, MSH2, MSH3, MSH6, MUTYH, MYC, NRAS, PALB2, PDGFRA, PDGFRL, PMS1, PMS2, POLD1, POLE, PTEN, PTPN12, PTPRJ, RAD51B, RAD51C, RAD51D, RAD54B, RAD54L, RET, RNF43, SMAD4 (MADH4), SOX9, SRC, STK11 (LKB1), TCF7L2, TGFBR2, TP53 (p53)
Metastatic Colorectal Cancers
AKT1, ATM, BRAF, ERBB2 (HER-2, NEU), KRAS, MET, NRAS, PIK3CA (p110-alpha)
Mismatch Repair (MMR) Genes
EPCAM, MLH1, MSH2, MSH6, PMS2
Other Colorectal Cancer Genes
DPYD, ERCC1, TYMS, UGT1A1