Target List
Estrogen Receptors
ESR1 (ERα), ESR2 (ERβ), GPER1
Estrogen Receptor Cofactors & Interacting Proteins
AHR, BCAR1, BRCA1, CAV1, CCND1, EFNA5, ESR1 (ERα), ESR2 (ERβ), HSP90AA1, IGF1, MED1, MTA1, NCOA1, NCOA2, NCOA3, NCOR1, NCOR2, NR0B1, NR0B2, NRIP1, PELP1, PGR, PHB2, SAFB, TFF1 (pS2), VDR
Estrogen Receptor Target Genes
Female Sex Differentiation
BCL2L1 (BCLXL), BCL2L1 (BCLXL), BCL2L1 (BCLXL), FST, NRIP1, PGR, VEGFA, WNT4, WNT5A
Male Sex Differentiation
BCL2L1 (BCLXL), BCL2L1 (BCLXL), BCL2L1 (BCLXL), CCND1, CYP19A1, WNT4, WNT5A
Ovulation Cycle
BCL2L1 (BCLXL), BCL2L1 (BCLXL), BCL2L1 (BCLXL), BMP4, ERBB2 (HER-2, NEU), FST, NRIP1, PGR, TGFB3, VEGFA, WNT5A
Pregnancy
FOS, JUNB, PGR, PTGS2 (COX2), SNAI1 (SNAIL), SOCS3, SPP1, TGFB3, WNT4
Mammary Gland Development
BMP4, CAV1, CCND1, ERBB2 (HER-2, NEU), ERBB3, IGFBP5, IRS1, NR3C1 (GRL), PGR, PTCH1, TGFB3, VEGFA, WNT4, WNT5A
Cardiovascular System Development
C3, CAV1, CCL2 (MCP-1), EGR3, ERBB2 (HER-2, NEU), ERBB3, JUNB, KLK3, MMP9, NRP1, PTCH1, PTGS2 (COX2), RARA, SOCS3, TGFA, THBS1 (TSP-1), VEGFA, WNT4, WNT5A
Nervous System Development
APBB1, BDNF, CCL2 (MCP-1), CITED2, CKB, CYP19A1, EGR3, ERBB2 (HER-2, NEU), ERBB3, FOS, FOXA1, L1CAM, LGALS1, NAB2, NR2F6, NR3C1 (GRL), NRP1, PTCH1, S100A6, SPP1, VEGFA, WNT4, WNT5A
Bone Development
BMP4, BMP7, IGF1, IGFBP5, JUNB, MMP9, NAB2, PTGS2 (COX2), SNAI1 (SNAIL), SPP1, TGFB3, WNT4, WNT5A
Growth Regulation
BMP7, CCN2, CCN3, CCN5, EBAG9, ERBB2 (HER-2, NEU), IGFBP4, IGFBP5, NRP1, PTCH1, SOCS3, SPP1, WNT5A
Transcription Factors
EGR3, FOS, FOXA1, JUNB, MAFF, MYC, NCOA1, NCOA3, NR3C1 (GRL), NR5A2, NRIP1, PGR, RARA, SNAI1 (SNAIL), XBP1
Other Estrogen Receptor Target Genes
AKAP1, CTSD, CYP1A1, G6PD, LPL, LTBP1, PDZK1, RALA, TFF1 (pS2)