Target List
TGFβ Signaling
ATF4, CDKN1B (P27KIP1), EMP1, GADD45B, HERPUD1, IFRD1, MYC, TNFSF10 (TRAIL)
WNT Signaling
AXIN2, CCN4, CCND1, CCND2, DAB2, FOSL1 (FRA-1), MMP7, MYC, PPARD
NFκB Signaling
BCL2A1 (BFL1), BCL2L1 (BCLXL), BCL2L1 (BCLXL), BCL2L1 (BCLXL), BIRC3 (c-IAP2), CCL5 (RANTES), CSF1 (MCSF), ICAM1, IFNG, STAT1, TNF
JAK / STAT Signaling
JAK1 & JAK2 / STAT1-Induced
IRF1
STAT3-Induced
BCL2L1 (BCLXL), BCL2L1 (BCLXL), BCL2L1 (BCLXL), CCND1, CEBPD, LRG1, MCL1, SOCS3
STAT5-Induced
BCL2L1 (BCLXL), BCL2L1 (BCLXL), BCL2L1 (BCLXL), CCND1, SOCS3
JAK1 & JAK3 / STAT6-Induced
FCER2
JAK1 & JAK3 / STAT6 Responsive
GATA3
p53 Signaling
BAX, BBC3 (PUMA), BTG2, CDKN1A (p21CIP1, WAF1), EGFR (ERBB1), FAS, GADD45A, PCNA, RB1
Notch Signaling
HES1, HES5, HEY1, HEY2, HEYL, ID1, JAG1, LFNG, NOTCH1
Hedgehog Signaling
BCL2, BMP2, BMP4, PTCH1, WNT1, WNT2B, WNT3A, WNT5A, WNT6
PPAR Signaling
ACSL3, ACSL4, ACSL5, CPT2, FABP1, OLR1, SLC27A4, SORBS1
Oxidative Stress
FTH1, GCLC, GCLM, GSR, HMOX1, NQO1, SQSTM1, TXN, TXNRD1
Hypoxia Signaling
ADM, ARNT, CA9, EPO, HMOX1, LDHA, SERPINE1 (PAI-1), SLC2A1, VEGFA