Target List
Toll-Like Receptors
CD180, SIGIRR, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TLR10
Pathogen-Specific Responses
Bacterial Response
CCL2 (MCP-1), CD14, CD180, FOS, HRAS, IL10, IL12A, IL1B, IL6, CXCL8 (IL8), IRAK1, HMGB1, HSPA1A (HSP70-1A), JUN, LTA (TNFB), LY86 (MD-1), LY96 (MD-2), NFKBIA (IκBα, MAD3), PTGS2 (COX2), RELA, RIPK2, TLR2, TLR4, TLR6, TNFRSF1A (TNFR1), TICAM1 (TRIF)
Viral Response
EIF2AK2, IFNB1, IFNG, IL12A, IL6, IRF3, PRKRA, RELA, TBK1, TLR3, TLR7, TLR8, TNF, TICAM1 (TRIF)
Fungal / Parasitic Response
CLEC4E, HRAS, HSPA1A (HSP70-1A), CXCL8 (IL8), TLR2, TIRAP
Toll-Like Receptor (TLR) Signaling
Negative Regulation of Toll-Like Receptor (TLR) Signaling
SARM1, SIGIRR, TOLLIP
TICAM1 (TRIF)-Dependent (MYD88-Independent) Signaling
IRF3, MAP3K7 (TAK1), TAB1, NR2C2 (TAK1), PELI1, TBK1, TICAM2 (TRAM), TLR3, TLR4, TRAF6, TICAM1 (TRIF)
MYD88-Dependent Signaling
IRAK1, IRAK2, MAP3K7 (TAK1), TAB1, MYD88, NR2C2 (TAK1), TIRAP, TLR1, TLR10, TLR2, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TRAF6
Signaling Downstream of Toll-Like Receptors
NFκB Signaling
BTK, CASP8 (FLICE), CHUK (IKKα), ECSIT, FADD, IKBKB (IKKβ), IL10, IL1B, IRAK1, IRAK2, IRF3, LY96 (MD-2), MAP3K1 (MEKK1), MAP3K7 (TAK1), MAP4K4, NFKB1, NFKB2, NFKBIA (IκBα, MAD3), NFKBIL1, NFRKB, PPARA, REL, RELA, TNF, TNFRSF1A (TNFR1), UBE2N
JNK / p38 Signaling
ELK1, FOS, IL1B, JUN, MAP2K3 (MEK3), MAP2K4 (MKK4, JNKK1), MAP3K1 (MEKK1), MAP3K7 (TAK1), MAPK8 (JNK1), MAPK8IP3, TNF
JAK / STAT Signaling
CCL2 (MCP-1), CSF2 (GM-CSF), IFNG, IL12A, IL2, IL6
Interferon Regulatory Factor (IRF) Signaling
CXCL10 (INP10), IFNA1, IFNB1, IFNG, IRF1, IRF3, TBK1
Cytokine Signaling
CCL2 (MCP-1), CSF3 (GCSF), IL1A, IL1B, IL6, IRAK1, IRAK2, RELA, SIGIRR, TNF, TNFRSF1A (TNFR1)
Regulation of Adaptive Immunity
CD80, CD86, HSPD1, IFNG, IL10, IL12A, IL1B, IL2, MAP3K7 (TAK1), TRAF6
Toll-Like Receptor Interacting Proteins & Adaptors
BTK, CD14, HMGB1, HRAS, HSPA1A (HSP70-1A), HSPD1, LY86 (MD-1), LY96 (MD-2), MAPK8IP3, MYD88, PELI1, RIPK2, SARM1, TICAM1 (TRIF), TICAM2 (TRAM), TIRAP, TOLLIP
Downstream Effectors of Toll-Like Receptor Signaling
CASP8 (FLICE), EIF2AK2, FADD, IRAK1, IRAK2, IRAK4, MAP3K7 (TAK1), TAB1, NR2C2 (TAK1), PPARA, PRKRA, ECSIT, TRAF6, UBE2N