Target List
Skeletal Development
Cartilage Condensation
BMP1, BMPR1B (ALK6), COL2A1, SOX9
Ossification
ACVR1 (ALK2), AHSG, BGLAP, BMP1, BMP2, BMP3, BMP4, BMP5, BMP6, BMP7, BMPR1A (ALK3), BMPR1B (ALK6), BMPR2, CDH11, CHRD, COL1A1, COL2A1, CSF1 (MCSF), CTSK, DLX5, EGFR (ERBB1), FGF2 (BFGF), FGFR2, GDF10 (BMP3B), GLI1, IGF1, IGF1R, IGF2, IHH, MMP2, MMP8, MMP9, NOG, RUNX2, SMAD1 (MADH1), SMAD3 (MADH3), SOX9, SP7, SPP1, TGFB1, TGFB2, TGFB3, TNFSF11 (RANKL), TWIST1
Osteoclast Differentiation
BGLAP, CSF1 (MCSF), TNF, TNFSF11 (RANKL)
Osteoblast Differentiation
ACVR1 (ALK2), BGLAP, BMP2, BMP4, BMP6, BMP7, BMPR1A (ALK3), BMPR1B (ALK6), BMPR2, CHRD, COL1A1, DLX5, FGF2 (BFGF), FGFR2, GDF10 (BMP3B), GLI1, IGF1, IHH, NOG, RUNX2, SMAD1 (MADH1), SMAD3 (MADH3), SP7, SPP1, TWIST1
Other Skeletal Development Genes
ALPL, COMP, FGFR1, TGFBR1 (ALK5), TGFBR2
Bone Mineral Metabolism
Bone Mineralization
ACVR1 (ALK2), AHSG, BGLAP, BMP2, BMP4, BMP6, BMP7, BMPR1A (ALK3), BMPR1B (ALK6), BMPR2, FGFR2, IGF1, SMAD3 (MADH3), SOX9, TGFB1, TGFB3, TWIST1
Calcium Ion Binding & Homeostasis
ANXA5, BGLAP, CALCR, CDH11, COMP, EGF, FGF2 (BFGF), ITGB1, MMP2, MMP8, TGFB1, VDR
Extracellular Matrix (ECM) Molecules
Collagens
COL10A1, COL14A1, COL15A1, COL1A1, COL1A2, COL2A1, COL3A1, COL5A1
Extracellular Matrix (ECM) Protease Inhibitors
AHSG, SERPINH1 (HSP47)
Extracellular Matrix (ECM) Proteases
CTSK, MMP10, MMP2, MMP8, MMP9, PHEX
Other Extracellular Matrix (ECM) Molecules
ALPL, BGN, FLT1 (VEGFR1)
Cell Adhesion Molecules
Cell-Cell Adhesion
BMP1, BMPR1B (ALK6), CDH11, COL14A1, COL2A1, EGFR (ERBB1), ICAM1, IHH, ITGB1, SOX9, TGFB1, TNF, TNFSF11 (RANKL), VCAM1
Cell-Extracellular Matrix (ECM) Adhesion
CD36, COL3A1, CSF1 (MCSF), ITGA1, ITGA2, ITGA3, ITGAM, ITGB1, SMAD3 (MADH3)
Other Cell Adhesion Molecules
BGLAP, COL15A1, COL5A1, COMP, FN1, TNF
Growth Factors
CSF2 (GM-CSF), CSF3 (GCSF), EGF, FGF1, FGF2 (BFGF), GDF10 (BMP3B), IGF1, IGF2, PDGFA, VEGFA, VEGFB
Transcription Factors
GLI1, NFKB1, RUNX2, SMAD1 (MADH1), SMAD2 (MADH2), SMAD3 (MADH3), SMAD4 (MADH4), SMAD5 (MADH5), SOX9, TWIST1