Target List
Notch Signaling Pathway
Notch Ligands
NOTCH1, NOTCH2, NOTCH2NLA, NOTCH3, NOTCH4
Notch Binding
DLL1 (DELTA1), DLL3, DLL4, DTX1, JAG1, JAG2, LFNG, MFNG, NUMB, RFNG
Notch Receptor Processing
ADAM10, ADAM17 (CD156B), NCSTN, PSEN1, PSEN2, PSENEN (PEN2)
Transcription Factors & Cofactors
EP300, HDAC1, MAML1, MAML2, NCOR2, RBPJL, SNW1 (SKIIP)
Notch Target Genes
Apoptosis
CDKN1A (p21CIP1, WAF1), CFLAR (CASPER), FOSL1 (FRA-1), ID1, IL2RA (CD25), NFKB1, PTCRA
Cell Cycle
CCND1, CDKN1A (p21CIP1, WAF1)
Cell Adhesion Molecules
CD44, ERBB2 (HER-2, NEU)
Cell Differentiation & Development
DTX1, HES1, HES5, HEY1, HEY2, HEYL, JAG1, KRT1, LFNG, LOR, NOTCH1, PPARG
Neurogenesis
ERBB2 (HER-2, NEU), FOS, HES1, HEY1, NR4A2 (NURR1)
Immune Response
CHUK (IKKα), IFNG, IL17B, IL2RA (CD25), NFKB1, NFKB2, STAT6
Transcription Factors & Cofactors
FOS, FOSL1 (FRA-1), HES1, HES5, HEY1, HEY2, HEYL, ID1, NFKB1, NFKB2, NR4A2 (NURR1), PPARG, STAT6
Other Notch Signaling Genes
Apoptosis
AXIN1, CTNNB1
Cell Cycle
AXIN1, CCNE1, JAG2, NOTCH2, VEGFD (VEGFD)
Cell Proliferation & Differentiation
FZD3, LRP5, PAX5, SHH, STIL, VEGFD (VEGFD)
Neurogenesis
NEURL1 (NEU1), PAX5, ZIC2 (HPE5)
Transcription Factors & Cofactors
AES (TLE5, Groucho), CBL, CTNNB1, GLI1, HOXB4, HR, PAX5, POFUT1, RUNX1 (AML1), SUFU, TLE1
Other Notch Signaling Genes
LMO2, MMP7, SEL1L, SH2D1A
Pathways Crosstalking with Notch Signaling
Hedgehog Signaling
GLI1, GSK3B, SHH, SMO, SUFU
WNT Signaling
AES (TLE5, Groucho), AXIN1, CCN4, CTNNB1, FZD2, FZD3, FZD4, FZD7, GSK3B, LRP5, TLE1, WNT11