Target List
Differentially Methylated Promoters
APBA1 (MINT1), APC, CADM1 (TSLC1), CDH1 (E-Cadherin), CDH13, CDKN1C (p57Kip2), CDKN2A (P16INK4A), CDKN2B (p15INK4b), CXCL12 (SDF1), CYP1B1, DLC1, FHIT, MGMT (AGT), MLH1, MTHFR, OPCML (OBCAM), PRDM2 (RIZ1), RASSF1, RASSF2, SFRP1, TCF21
Metastatic Potential
ANXA5, DUSP6, ERBB3, HGF, HMMR, IRF4, LCK, MET, MMD, NF1, STAT1, STAT2
Differentially Expressed Genes in Adenocarcinoma (AC) Versus Squamous Cell Carcinoma (SCC)
Higher in Adenocarcinoma than in Squamous Cell Carcinoma
CLCA2, DSG3, KRT5, KRT14, SPRR1A
Higher in Squamous Cell Carcinoma than in Adenocarcinoma
AGR2, LGSN, NKX2-1, SFTA3, SPINK1
Up-Regulated in Lung Cancer
CEACAM5, COL11A1, CP, CXCL13, GREM1, MKI67, MMP1, MMP12, SPINK1, SPP1, TOP2A, TOX3
Down-Regulated in Lung Cancer
AGER, CA4, CLDN18, CLIC5, FABP4, GPM6A, SCGB1A1, SFTPC, SOSTDC1, WIF1
AKT & PI3 Kinase Signaling
AKT1, BCL2, CDH1 (E-Cadherin), CDKN2A (P16INK4A), EGFR (ERBB1), NFKB1, TP53 (p53), VEGFA
Apoptosis
ANXA5, APC, BCL2, BIRC5, BRAF, CADM1 (TSLC1), CDH1 (E-Cadherin), CDH13, CDKN2A (P16INK4A), DLC1, EGFR (ERBB1), ERBB2 (HER-2, NEU), ERBB3, HGF, HRAS, KRAS, LCK, MLH1, MMP9, NF1, NFKB1, PTGS2 (COX2), SFRP1, STAT1, TERT, TGFB1, TNF, TOP2A, TP53 (p53), VEGFA
Regulation of the Cell Cycle
APC, BCL2, BIRC5, CDKN1C (p57Kip2), CDKN2A (P16INK4A), CDKN2B (p15INK4b), EGFR (ERBB1), PTGS2 (COX2), RB1, TGFB1, TNF, TP53 (p53)
Immune Response
BCL2, CADM1 (TSLC1), CSF3 (GCSF), CXCL12 (SDF1), CXCL13, IRF4, LCK, MLH1, MMD, NFKB1, PAX5, STAT1, STAT2, TGFB1, TNF, TP53 (p53), VEGFA
Extracellular Matrix (ECM) & Cell Adhesion Molecules
CADM1 (TSLC1), CDH1 (E-Cadherin), CDH13, CEACAM6, CLDN18, COL11A1, DSG3, GPM6A, HMMR, KRT14, KRT5, MET, MMP1, MMP12, MMP9, SFTA3, SFTPC