Target List
Fungal Pattern Recognition Receptors (PRRs)
Beta-Glycan Responsive
CD36, CD5, CLEC7A (DECTIN1), ITGAM, ITGB2, SCARF1, TLR2
Mannose / Chitin Responsive
CD207, CD209, CHIA, CLEC6A (DECTIN2), MRC1, TLR2, TLR4
Other Fungal Pattern Recognition Receptors (PRRs)
COLEC12, NLRP3, NPTX1, PTX3, TLR9
Signal Transduction
Dectin-1 Signaling
BCL10, CARD9, CLEC7A (DECTIN1), MALT1, PLCG2, RAF1, SYK
NFκB Signaling
BCL10, CARD9, CASP1 (ICE), CASP8 (FLICE), CD40 (TNFRSF5), IKBKB (IKKβ), IL10, IL1B, IRAK1, IRAK4, MALT1, MAP3K7 (TAK1), NFKB1, NFKBIA (IκBα, MAD3), STAT1, TNF
Toll-Like Receptor (TLR) Signaling
CASP8 (FLICE), CD14, FOS, IRAK1, IRAK4, ITGB2, JUN, MAP2K4 (MKK4, JNKK1), MAP3K7 (TAK1), MAPK14 (p38ALPHA), MAPK8 (JNK1), MYD88, NFKB1, TIRAP, TLR2, TLR4, TLR9, TRAF6
Complement Signaling
C3, C5AR1 (GPR77), ITGAM, ITGB2, LYN, MBL2, SYK
NOD-Like Receptor (NLR) Signaling
CARD9, CASP1 (ICE), NLRP3, PYCARD (TMS1, ASC)
Inflammation
C3, CCL2 (MCP-1), CCL20 (MIP-3A), CCL5 (RANTES), CCR1, CD14, CD40 (TNFRSF5), CLEC7A (DECTIN1), CXCL1 (GRO1, GROa, SCYB1), CXCL10 (INP10), CXCL11 (I-TAC, IP-9), CXCL2 (GRO2, GROb, SCYB2), CXCL9 (MIG), F3, FOS, IL10, IL1A, IL1B, IL2, IL23A, IL6, CXCL8 (IL8), ITGB2, LYN, MBL2, MYD88, NFKB1, PTGS2 (COX2), TIRAP, TLR2, TLR4, TLR9, TNF
Phagocytosis
C3, CD14, CD36, CLEC7A (DECTIN1), COLEC12, FCGR1A, FCN1, MBL2, SFTPD
Genes Responsive to Specific Pathogenic Fungi
Candida albicans
CCL2 (MCP-1), CCL20 (MIP-3A), CCL5 (RANTES), CCR1, CD14, CD209, CD83, CLEC6A (DECTIN2), CLEC7A (DECTIN1), CSF2 (GM-CSF), CSF3 (GCSF), CXCL1 (GRO1, GROa, SCYB1), CXCL10 (INP10), CXCL11 (I-TAC, IP-9), CXCL2 (GRO2, GROb, SCYB2), CXCL9 (MIG), FCGR1A, FCGR3A, IFNG, IL12B, IL18, IL1A, IL1B, IL1R1, IL23A, IL6, CXCL8 (IL8), MYD88, NFKB1, PTGS2 (COX2), SOCS3, TLR2, TNF
Aspergillus fumigatus
C3, CASP1 (ICE), CASP8 (FLICE), CCL2 (MCP-1), CCL20 (MIP-3A), CCL5 (RANTES), CCR1, CD14, CD40 (TNFRSF5), CD83, CLEC6A (DECTIN2), CLEC7A (DECTIN1), CSF2 (GM-CSF), CSF3 (GCSF), CXCL1 (GRO1, GROa, SCYB1), CXCL10 (INP10), CXCL11 (I-TAC, IP-9), CXCL2 (GRO2, GROb, SCYB2), CXCL9 (MIG), F2RL1 (PAR2), F3, FCGR1A, FCGR2A, FCN1, IFNG, IL10, IL12A, IL12B, IL18, IL1A, IL1B, IL1R1, IL6, CXCL8 (IL8), JUN, MALT1, MAPK14 (p38ALPHA), MBL2, MYD88, NFKBIA (IκBα, MAD3), PTGS2 (COX2), PTPN6, PTX3, SFTPD, SOCS3, ST3GAL5, STAT1, SYK, TLR2, TLR4, TLR9, TNF
Cryptococcus neoformans
C3, CD5, CCL2 (MCP-1), CD40 (TNFRSF5), SOCS3