Target List
Dysregulated During Infertility
CFD, CLDN4, COMP, CRABP2, DKK1, ESR2 (ERβ), GADD45A, GAST, GDF15, GPX3, IGFBP1, IL15, MAOA, MSX1, OLFM1, PAEP, SFRP4, SPP1
Receptive Endometrium
AREG, CALCA, CSF1 (MCSF), EGF, HOXA10, HOXA11, LEP (Leptin), LIF, LIFR, MUC1 (mucin), PAEP, PGR, PTGS1 (COX1), PTGS2 (COX2), SELL (LECAM-1)
Signal Transduction
Interleukin-1 Signaling
IL1A, IL1B, IL1R1
WNT Signaling
CDH1 (E-Cadherin), CTNNB1, DKK1, MMP7, PTGS2 (COX2), SFRP4, TP53 (p53), WNT2
Prostaglandin Signaling
PTGS1 (COX1), PTGS2 (COX2)
Other Signal Transduction Genes
AKT1, EGF, EGFR (ERBB1), GDF15, STAT3, TGFB1
Leukocyte Migration
CALCA, CCL5 (RANTES), CLDN4, CTNNB1, CXCL12 (SDF1), FBN1, FN1, ICAM1, ITGA4 (CD49D), ITGAV, ITGB3, LAMC2, MMP2, MMP7, MMP9, SELL (LECAM-1), SPP1, VCAM1
Cell Cycle
CCNB1, GADD45A, MKI67, PCNA, STMN1, TGFB1, TP53 (p53)
Coagulation
C2, C3, CD55, CFD, F3
Apoptosis
BAX, BCL2, CASP3, COMP, GADD45A, IL1B, MSX1, TNF, TNFRSF10B (DR5), TP53 (p53)
Cytokines
CCL5 (RANTES), CSF1 (MCSF), CXCL12 (SDF1), IL11, IL15, IL1A, IL1B, IL1R1, IL6, LIFR, TGFB1
Other Genes Involved in Pregnancy
ANXA2, APOD, AR, ESR1 (ERα), HBEGF, IGF1, KDR (VEGFR3), MID1, PGF, PRL, SOD1, TIMP1, VEGFA