Target List
Huntingtin Cofactors
CLTC, CREBBP (CBP), DCTN1, DLG4 (PSD95), EGFR (ERBB1), GRB2, HAP1, HDAC2, HIP1, MAP3K10, NCOR1, PACSIN1, PRPF40A, PTPN11, RCOR1, REST, SIN3A, SP1, SYMPK, TBP, TP53 (p53)
SP1 & REST Target Genes
SP1 Target Genes
AKT1, APOE, AQP1, ARFIP2, BDNF, C3, CASP8 (FLICE), CD44, CLTC, CREBBP (CBP), DLG4 (PSD95), FGF12, GJA1 (CX43), GJB6, GPX1, GRB2, GRIN2A, HAP1, HDAC1, HOMER1, HPCA, HTT, KCNC3, LPL, MAP3K10, PACSIN1, PRKCB, RAB6A, REST, RILP, RXRB, SGK1, SIN3A, SOD1, SOX2, SP1, SYMPK, SYN1, TGM2, TOLLIP, TP53 (p53), TUBB
REST Target Genes
BDNF, CALB1, DLG4 (PSD95), EEF1A2, ELMO1, FGF12, GABRD, GRIN2A, KCNAB2, KCNC3, NEFL, RPH3A, RXRB, SNAP25, SYN1, TOLLIP, TUBB
Cytoskeleton Regulators
AKT1, APOE, ARFIP2, CASP8 (FLICE), DCTN1, DLG4 (PSD95), ELMO1, GRIN2A, HAP1, HIP1, HOMER1, IFT57, ITPR1, NCOR1, NEFL, PACSIN1, SYMPK, TAC1, TUBB
Ion Transport
AKT1, AQP1, ATP2B2, GABRD, GRIN2A, HOMER1, HTT, ITPR1, KCNAB1, KCNAB2, KCNC3, PPP3CA, SGK1
Regulation of Synaptic Transmission
APOE, BDNF, CALB1, EGFR (ERBB1), GNAQ, GRIN2A, GRIN2B, HTT, PPP3CA, TAC1
Postsynaptic Density (PSD)
DLG4 (PSD95), GRIN2A, HOMER1, ITPR1
Synaptic Proteins
DLG4 (PSD95), GABRD, GRIN2A, GRIN2B, HOMER1, ITPR1, RPH3A, SNAP25, SYN1
Neurotransmitter Receptors
CNR1, GABRD, GRIN2A, GRIN2B, GRM5, NTRK2
Processes Dysregulated in Huntington's Disease
Apoptosis
AKT1, APOE, BAX, BDNF, CASP3, CASP8 (FLICE), CD44, CREB1, EEF1A2, EGFR (ERBB1), ELMO1, GJB6, GRIN2A, HIP1, HTT, IFT57, IGF1, MAP3K10, NEFL, NGEF, SGK1, SLC25A4, SOX2, TBP, TP53 (p53), TUBB, ZBTB16
Endocytosis
C3, CLTC, HIP1, PACSIN1
Oxidation / Reduction
APOE, BBOX1, EGFR (ERBB1), GPX1, KCNAB1, KCNAB2, PLOD2, PPARGC1A (PGC-1α), SOD1
Calcium Signaling & Homeostasis
APOE, ATP2B2, GNAQ, GRIN2A, GRIN2B, HOMER1, ITPR1, PLCB1, PPP3CA, TAC1, TGM2
Other Huntington's Disease Genes
PGK1, RGS4, SLC14A1