PIK3CB
PIK3CB Gene Summary
This gene encodes an isoform of the catalytic subunit of phosphoinositide 3-kinase (PI3K). These kinases are important in signaling pathways involving receptors on the outer membrane of eukaryotic cells and are named for their catalytic subunit. The encoded protein is the catalytic subunit for PI3Kbeta (PI3KB). PI3KB has been shown to be part of the activation pathway in neutrophils which have bound immune complexes at sites of injury or infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]
Details
| Type | Protein Coding |
| Official Symbol | PIK3CB |
| Official Name | phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [Source:HGNC Symbol;Acc:HGNC:8976] |
| Ensembl ID | ENSG00000051382 |
| Bio databases IDs | |
| Aliases | phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta |
| Synonyms | 1110001J02Rik,LOC100910021,P110BETA,P110 β,phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta,phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta,phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit β,phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit β,PI3K,PI3KBETA,Pi-3-Kinase, p110, Beta Subunit,Pi-3-Kinase, p110, β Subunit,Pi3k β,PIK3C1,PK3CB |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- PI3-kinase family, p85-binding domain
- phosphatidylinositol 3-kinase
- protein kinase
- Phosphoinositide 3-kinase, catalytic domain
- Protein Kinases, catalytic domain
- Phosphatidylinositol 3- and 4-kinase
- phosphatidylinositol-4,5-bisphosphate 3-kinase
- protein binding
- PI3-kinase family, ras-binding domain
- C2 domain
- PI3Ka
Pathways
Biological processes and signaling networks where the PIK3CB gene plays a role, providing insight into its function and relevance in health or disease.
- Angiopoietin Signaling
- Apelin Cardiomyocyte Signaling Pathway
- Cancer Drug Resistance By Drug Efflux
- CCR3 Signaling in Eosinophils
- Clathrin-mediated Endocytosis Signaling
- CNTF Signaling
- CXCR4 Signaling
- Docosahexaenoic Acid (DHA) Signaling
- ErbB Signaling
- ErbB4 Signaling
- Glucocorticoid Receptor Signaling
- Growth Hormone Signaling
- HER-2 Signaling in Breast Cancer
- HGF Signaling
- IL-9 Signaling
- JAK/Stat Signaling
- LPS-stimulated MAPK Signaling
- MSP-RON Signaling Pathway
- Neurotrophin/TRK Signaling
- NGF Signaling
- Nitric Oxide Signaling in the Cardiovascular System
- p53 Signaling
- PDGF Signaling
- Role of JAK1 and JAK3 in γc Cytokine Signaling
- Th2 Pathway
- Thyroid Cancer Signaling
- VEGF Family Ligand-Receptor Interactions
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- ALK
- DIRAS2
- CDC42
- EXOSC5
- CC2D1A
- PTK2B
- PTGER3
- RAC1
- SRC
- PIK3R1
disease
- neoplasia
- gastrointestinal neoplasia
- metastasis
- colorectal neoplasia
- neoplastic cell transformation
- cancer
- respiratory tract infection
- metastatic breast cancer
- oligozoospermia
- soft tissue sarcoma
regulated by
- methylprednisolone
- FMR1
- p85 PIK3R
- receptor protein tyrosine kinase
- imatinib
- cantharidin
- TLR
- C-C chemokine receptor
- GRM group I
- NFAT5
regulates
- SLC2A1
- AR
- VEGF
- GSK3B
- SLC2A4
- p70 S6k
- HIF1A
- PIK3CB
- nitric oxide
- phosphatidylinositol-3,4,5-triphosphate
role in cell
- expression in
- phosphorylation in
- proliferation
- invasion by
- migration
- apoptosis
- growth
- formation
- activation in
- degradation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- perinuclear region
- Nucleus
- midbody
- cell-cell contacts
- cytosol
- nucleoplasm
- nucleoli
- synapse
- brush border
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the PIK3CB gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- embryonic cleavage
- positive regulation of Rac protein signal transduction
- positive regulation of nitric oxide biosynthetic process
- negative regulation of MAPK cascade
- phosphatidylinositol-3-phosphate biosynthetic process
- phosphatidylinositol phosphorylation
- homophilic cell adhesion
- sphingosine-1-phosphate signaling pathway
- negative regulation of vascular endothelial growth factor signaling pathway
- chemotaxis
- protein kinase B signaling cascade
- response to ischemia
- autophagy
- phosphorylation
- platelet activation
- platelet aggregation
- cell migration
- positive regulation of endothelial cell migration
- angiogenesis involved in wound healing
- G-protein coupled receptor signaling pathway
- signal transduction
- positive regulation of neutrophil apoptotic process
- transmembrane receptor protein tyrosine kinase signaling pathway
- endocytosis
- cellular calcium ion homeostasis
- positive regulation of autophagy
- regulation of cell-matrix adhesion
- phosphatidylinositol-mediated signaling
- positive regulation of gene expression
- endothelial cell proliferation
- regulation of clathrin-mediated endocytosis
- negative regulation of protein kinase B signaling cascade
CELLULAR COMPONENT
Where in the cell the gene product is active
- 1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex
- nucleus
- phosphatidylinositol 3-kinase complex
- cytoplasm
- intracellular membrane-bounded organelle
- cytosol
- midbody
- nucleolus
- plasma membrane
- nucleoplasm
MOLECULAR FUNCTION
What the gene product does at the molecular level
- ATP binding
- protein binding
- insulin receptor substrate binding
- phosphatidylinositol-4,5-bisphosphate 3-kinase activity
- kinase activity
- 1-phosphatidylinositol-4-phosphate 3-kinase activity
- 1-phosphatidylinositol-3-kinase activity