FGF Signaling
Fibroblast growth factor receptor (FGFR) belongs to the family of receptor tyrosine kinases (RTKs). Binding of fibroblast growth factor (FGF) to its receptor induces receptor dimerization and tyrosine phosphorylation. The phosphorylated form of the receptor is now capable of initiating several signal transducing pathways depending of cell specificity.FGFR phosphorylation causes the tyrosine phosphorylation of SNT1 which leads to GRB2-mediated complex formation with docking protein GAB and nucleotide exchange factor SOS. These key events then lead to the activation of one of several pathways: the Ras/Raf/MEK/ERK pathway, the Rac1/MEKK/p38MAPK pathway or the PI3K/AKT pathway...
Pathway Summary
Fibroblast growth factor receptor (FGFR) belongs to the family of receptor tyrosine kinases (RTKs). Binding of fibroblast growth factor (FGF) to its receptor induces receptor dimerization and tyrosine phosphorylation. The phosphorylated form of the receptor is now capable of initiating several signal transducing pathways depending of cell specificity.FGFR phosphorylation causes the tyrosine phosphorylation of SNT1 which leads to GRB2-mediated complex formation with docking protein GAB and nucleotide exchange factor SOS. These key events then lead to the activation of one of several pathways: the Ras/Raf/MEK/ERK pathway, the Rac1/MEKK/p38MAPK pathway or the PI3K/AKT pathway. Finally, transcriptional regulators like CREB, STAT3 and ATF-2 are activated leading to various cellular processes like cell growth, differentiation and angiogenesis. This is a unique mechanism for generation of signal diversity whereby coordinated assembly of a multi-docking protein complex can activate different downstream signaling pathways. FGFR is also able to directly activate PLCĪ³ and consequently cause the activation of protein kinase C and increased intracellular Ca+2.FGFs are heparin binding proteins. They are closely related to other heparin binding proteins like hepatocyte growth factor (HGF). Its receptor is MET. Signaling by HGF via MET involves the docking proteins GAB and CRK eventually leading to the activation of JNK and CREB and the promotion of angiogenesis.
FGF Signaling Genes list
Explore Genes related to FGF Signaling
AKT1AKT serine/threonine kinase 1 AKT2AKT serine/threonine kinase 2 AKT3AKT serine/threonine kinase 3 ATF2activating transcription factor 2 ATF4activating transcription factor 4 CREB1cAMP responsive element binding protein 1 CREB3cAMP responsive element binding protein 3 CREB3L1cAMP responsive element binding protein 3 like 1 CREB3L2cAMP responsive element binding protein 3 like 2 CREB3L3cAMP responsive element binding protein 3 like 3 CREB3L4cAMP responsive element binding protein 3 like 4 CREB5cAMP responsive element binding protein 5 CREBBPCREB binding protein CRKCRK proto-oncogene, adaptor protein CRKLCRK like proto-oncogene, adaptor protein FGF1fibroblast growth factor 1 FGF10fibroblast growth factor 10 FGF11fibroblast growth factor 11 FGF12fibroblast growth factor 12 FGF13fibroblast growth factor 13 FGF14fibroblast growth factor 14 FGF16fibroblast growth factor 16 FGF17fibroblast growth factor 17 FGF18fibroblast growth factor 18 FGF19fibroblast growth factor 19 FGF2fibroblast growth factor 2 FGF20fibroblast growth factor 20 FGF21fibroblast growth factor 21 FGF22fibroblast growth factor 22 FGF23fibroblast growth factor 23 FGF3fibroblast growth factor 3 FGF4fibroblast growth factor 4 FGF5fibroblast growth factor 5 FGF6fibroblast growth factor 6 FGF7fibroblast growth factor 7 FGF8fibroblast growth factor 8 FGF9fibroblast growth factor 9 FGFR1fibroblast growth factor receptor 1 FGFR2fibroblast growth factor receptor 2 FGFR3fibroblast growth factor receptor 3 FGFR4fibroblast growth factor receptor 4 FGFRL1fibroblast growth factor receptor like 1 FRS2fibroblast growth factor receptor substrate 2 GAB1GRB2 associated binding protein 1 GRB2growth factor receptor bound protein 2 HGFhepatocyte growth factor HRASHRas proto-oncogene, GTPase ITPR1inositol 1,4,5-trisphosphate receptor type 1 MAP2K1mitogen-activated protein kinase kinase 1 MAP2K3mitogen-activated protein kinase kinase 3 MAP2K6mitogen-activated protein kinase kinase 6 MAP3K1mitogen-activated protein kinase kinase kinase 1 MAP3K5mitogen-activated protein kinase kinase kinase 5 MAPK1mitogen-activated protein kinase 1 MAPK11mitogen-activated protein kinase 11 MAPK12mitogen-activated protein kinase 12 MAPK13mitogen-activated protein kinase 13 MAPK14mitogen-activated protein kinase 14 MAPK3mitogen-activated protein kinase 3 MAPK8mitogen-activated protein kinase 8 MAPKAPK2MAPK activated protein kinase 2 METMET proto-oncogene, receptor tyrosine kinase PIK3C2Aphosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha PIK3C2Bphosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta PIK3C2Gphosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma PIK3C3phosphatidylinositol 3-kinase catalytic subunit type 3 PIK3CAphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha PIK3CBphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta PIK3CDphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta PIK3CGphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma PIK3R1phosphoinositide-3-kinase regulatory subunit 1 PIK3R2phosphoinositide-3-kinase regulatory subunit 2 PIK3R3phosphoinositide-3-kinase regulatory subunit 3 PIK3R4phosphoinositide-3-kinase regulatory subunit 4 PIK3R5phosphoinositide-3-kinase regulatory subunit 5 PIK3R6phosphoinositide-3-kinase regulatory subunit 6 PLCG1phospholipase C gamma 1 PRKCAprotein kinase C alpha PTPN11protein tyrosine phosphatase non-receptor type 11 PTPN6protein tyrosine phosphatase non-receptor type 6 RAC1Rac family small GTPase 1 RAF1Raf-1 proto-oncogene, serine/threonine kinase RPS6KA5ribosomal protein S6 kinase A5 SOS1SOS Ras/Rac guanine nucleotide exchange factor 1 SOS2SOS Ras/Rho guanine nucleotide exchange factor 2 STAT3signal transducer and activator of transcription 3