PPARα/RXRα Activation
The Peroxisome proliferator activated receptor α (PPARα) is a ligand activated transcription factor that belongs to the family of nuclear receptors. PPARα is activated by polyunsaturated fatty acids and synthetic drugs like fibrates. After hetrodimerization with its partner RXRα, PPARα plays a central role in fatty acid oxidation and uptake in tissues like liver, heart, skeletal muscle and kidney. In addition, PPARα is also expressed in endothelial cells, vascular smooth muscle cells and macrophages where it exerts anti-inflammatory and anti-oxidative effects. PPARα agonists decrease the progression of diseases like atherosclerosis and the metabolic syndrome by controlling dyslipidemia, inflammation and glucose intolerance, underscoring PPARα as an important pharmacological target...
Pathway Summary
The Peroxisome proliferator activated receptor α (PPARα) is a ligand activated transcription factor that belongs to the family of nuclear receptors. PPARα is activated by polyunsaturated fatty acids and synthetic drugs like fibrates. After hetrodimerization with its partner RXRα, PPARα plays a central role in fatty acid oxidation and uptake in tissues like liver, heart, skeletal muscle and kidney. In addition, PPARα is also expressed in endothelial cells, vascular smooth muscle cells and macrophages where it exerts anti-inflammatory and anti-oxidative effects. PPARα agonists decrease the progression of diseases like atherosclerosis and the metabolic syndrome by controlling dyslipidemia, inflammation and glucose intolerance, underscoring PPARα as an important pharmacological target.
PPARα/RXRα Activation Genes list
Explore Genes related to PPARα/RXRα Activation
ABCA1ATP binding cassette subfamily A member 1 ACAA1acetyl-CoA acyltransferase 1 ACADLacyl-CoA dehydrogenase long chain ACOX1acyl-CoA oxidase 1 ACVR1activin A receptor type 1 ACVR1Bactivin A receptor type 1B ACVR1Cactivin A receptor type 1C ACVR2Aactivin A receptor type 2A ACVR2Bactivin A receptor type 2B ADCY1adenylate cyclase 1 ADCY10adenylate cyclase 10 ADCY2adenylate cyclase 2 ADCY3adenylate cyclase 3 ADCY4adenylate cyclase 4 ADCY5adenylate cyclase 5 ADCY6adenylate cyclase 6 ADCY7adenylate cyclase 7 ADCY8adenylate cyclase 8 ADCY9adenylate cyclase 9 ADIPOQadiponectin, C1Q and collagen domain containing ADIPOR1adiponectin receptor 1 ADIPOR2adiponectin receptor 2 AIParyl hydrocarbon receptor interacting protein AP2A2adaptor related protein complex 2 subunit alpha 2 APOA1apolipoprotein A1 APOA2apolipoprotein A2 BCL3BCL3 transcription coactivator BMPR2bone morphogenetic protein receptor type 2 CAMPcathelicidin antimicrobial peptide CAND1cullin associated and neddylation dissociated 1 CD36CD36 molecule CHD5chromodomain helicase DNA binding protein 5 CHUKcomponent of inhibitor of nuclear factor kappa B kinase complex CKAP5cytoskeleton associated protein 5 CLOCKclock circadian regulator CPT1Bcarnitine palmitoyltransferase 1B CREBBPCREB binding protein CYP2C18cytochrome P450 family 2 subfamily C member 18 CYP2C19cytochrome P450 family 2 subfamily C member 19 CYP2C8cytochrome P450 family 2 subfamily C member 8 CYP2C9cytochrome P450 family 2 subfamily C member 9 ELP1elongator acetyltransferase complex subunit 1 EP300E1A binding protein p300 ERASES cell expressed Ras FASNfatty acid synthase GH1growth hormone 1 GHRgrowth hormone receptor GKglycerol kinase GNA11G protein subunit alpha 11 GNA14G protein subunit alpha 14 GNA15G protein subunit alpha 15 GNAQG protein subunit alpha q GNASGNAS complex locus GOT2glutamic-oxaloacetic transaminase 2 GPD1glycerol-3-phosphate dehydrogenase 1 GPD2glycerol-3-phosphate dehydrogenase 2 GRB2growth factor receptor bound protein 2 GUCY1A1guanylate cyclase 1 soluble subunit alpha 1 GUCY1B1guanylate cyclase 1 soluble subunit beta 1 HELZ2helicase with zinc finger 2 HRASHRas proto-oncogene, GTPase HSP90AA1heat shock protein 90 alpha family class A member 1 HSP90AB1heat shock protein 90 alpha family class B member 1 HSP90B1heat shock protein 90 beta family member 1 IKBKBinhibitor of nuclear factor kappa B kinase subunit beta IKBKEinhibitor of nuclear factor kappa B kinase subunit epsilon IKBKGinhibitor of nuclear factor kappa B kinase regulatory subunit gamma IL18RAPinterleukin 18 receptor accessory protein IL1Binterleukin 1 beta IL1R1interleukin 1 receptor type 1 IL1R2interleukin 1 receptor type 2 IL1RAPinterleukin 1 receptor accessory protein IL1RAPL1interleukin 1 receptor accessory protein like 1 IL1RAPL2interleukin 1 receptor accessory protein like 2 IL1RL1interleukin 1 receptor like 1 IL1RL2interleukin 1 receptor like 2 IL6interleukin 6 INSinsulin INSRinsulin receptor IRS1insulin receptor substrate 1 ITGB5integrin subunit beta 5 JAK2Janus kinase 2 JUNJun proto-oncogene, AP-1 transcription factor subunit KRASKRAS proto-oncogene, GTPase LPLlipoprotein lipase MAP2K1mitogen-activated protein kinase kinase 1 MAP2K2mitogen-activated protein kinase kinase 2 MAP2K3mitogen-activated protein kinase kinase 3 MAP2K4mitogen-activated protein kinase kinase 4 MAP2K6mitogen-activated protein kinase kinase 6 MAP2K7mitogen-activated protein kinase kinase 7 MAP3K14mitogen-activated protein kinase kinase kinase 14 MAP3K7mitogen-activated protein kinase kinase kinase 7 MAP4K4mitogen-activated protein kinase kinase kinase kinase 4 MAPK1mitogen-activated protein kinase 1 MAPK14mitogen-activated protein kinase 14 MAPK3mitogen-activated protein kinase 3 MAPK8mitogen-activated protein kinase 8 MED1mediator complex subunit 1 MED12mediator complex subunit 12 MED23mediator complex subunit 23 MED24mediator complex subunit 24 MEF2Cmyocyte enhancer factor 2C MRASmuscle RAS oncogene homolog NCOA3nuclear receptor coactivator 3 NCOA6nuclear receptor coactivator 6 NCOR1nuclear receptor corepressor 1 NFKB1nuclear factor kappa B subunit 1 NFKB2nuclear factor kappa B subunit 2 NFKBIANFKB inhibitor alpha NFKBIBNFKB inhibitor beta NFKBIDNFKB inhibitor delta NFKBIENFKB inhibitor epsilon NOTUMnotum, palmitoleoyl-protein carboxylesterase NR0B2nuclear receptor subfamily 0 group B member 2 NR2C2nuclear receptor subfamily 2 group C member 2 NR2F1nuclear receptor subfamily 2 group F member 1 NRASNRAS proto-oncogene, GTPase PDIA3protein disulfide isomerase family A member 3 PLCB1phospholipase C beta 1 PLCB2phospholipase C beta 2 PLCB3phospholipase C beta 3 PLCB4phospholipase C beta 4 PLCD1phospholipase C delta 1 PLCD3phospholipase C delta 3 PLCD4phospholipase C delta 4 PLCE1phospholipase C epsilon 1 PLCG1phospholipase C gamma 1 PLCG2phospholipase C gamma 2 PLCH1phospholipase C eta 1 PLCH2phospholipase C eta 2 PLCL1phospholipase C like 1 (inactive) PLCL2phospholipase C like 2 PLCZ1phospholipase C zeta 1 PPARAperoxisome proliferator activated receptor alpha PPARGC1APPARG coactivator 1 alpha PRKAA1protein kinase AMP-activated catalytic subunit alpha 1 PRKAA2protein kinase AMP-activated catalytic subunit alpha 2 PRKAB1protein kinase AMP-activated non-catalytic subunit beta 1 PRKAB2protein kinase AMP-activated non-catalytic subunit beta 2 PRKACAprotein kinase cAMP-activated catalytic subunit alpha PRKACBprotein kinase cAMP-activated catalytic subunit beta PRKACGprotein kinase cAMP-activated catalytic subunit gamma PRKAG1protein kinase AMP-activated non-catalytic subunit gamma 1 PRKAG2protein kinase AMP-activated non-catalytic subunit gamma 2 PRKAG3protein kinase AMP-activated non-catalytic subunit gamma 3 PRKAR1Aprotein kinase cAMP-dependent type I regulatory subunit alpha PRKAR1Bprotein kinase cAMP-dependent type I regulatory subunit beta PRKAR2Aprotein kinase cAMP-dependent type II regulatory subunit alpha PRKAR2Bprotein kinase cAMP-dependent type II regulatory subunit beta PRKCAprotein kinase C alpha PRKCBprotein kinase C beta RAF1Raf-1 proto-oncogene, serine/threonine kinase RALARAS like proto-oncogene A RALBRAS like proto-oncogene B RAP1ARAP1A, member of RAS oncogene family RAP1BRAP1B, member of RAS oncogene family RAP2ARAP2A, member of RAS oncogene family RAP2BRAP2B, member of RAS oncogene family RASD1ras related dexamethasone induced 1 RASD2RASD family member 2 RELREL proto-oncogene, NF-kB subunit RELARELA proto-oncogene, NF-kB subunit RELBRELB proto-oncogene, NF-kB subunit RRASRAS related RRAS2RAS related 2 RXRAretinoid X receptor alpha SHC1SHC adaptor protein 1 SLC27A1solute carrier family 27 member 1 SMAD2SMAD family member 2 SMAD3SMAD family member 3 SMAD4SMAD family member 4 SOS1SOS Ras/Rac guanine nucleotide exchange factor 1 SOS2SOS Ras/Rho guanine nucleotide exchange factor 2 STAT5Bsignal transducer and activator of transcription 5B TGFB1transforming growth factor beta 1 TGFB2transforming growth factor beta 2 TGFB3transforming growth factor beta 3 TGFBR1transforming growth factor beta receptor 1 TGFBR2transforming growth factor beta receptor 2 TGFBR3transforming growth factor beta receptor 3 TGS1trimethylguanosine synthase 1 TRAF6TNF receptor associated factor 6