icon_0328_cc_gen_hmr_bacteria-s

Role of IL-17A in Psoriasis

The IL-17 family of cytokines contains six members: IL-17 (also known as IL-17A), IL-17B, IL-17C, IL-17D, IL-17E (also known as IL-25) and IL-17F. These cytokines consist of 163-202 amino acids with molecular masses of 20-30 kDa. They share four conserved cysteine residues at the C-terminal region that may participate in the formation of intermolecular disulfide linkages. IL-17A is the most extensively researched cytokine in this family. It is a disulfide-linked homodimeric glycoprotein which binds to and activates a heterodimeric transmembrane receptor complex consisting of IL-17RC and IL-17RA subunits...

Role of IL-17A in Psoriasis

Pathway Summary

The IL-17 family of cytokines contains six members: IL-17 (also known as IL-17A), IL-17B, IL-17C, IL-17D, IL-17E (also known as IL-25) and IL-17F. These cytokines consist of 163-202 amino acids with molecular masses of 20-30 kDa. They share four conserved cysteine residues at the C-terminal region that may participate in the formation of intermolecular disulfide linkages. IL-17A is the most extensively researched cytokine in this family. It is a disulfide-linked homodimeric glycoprotein which binds to and activates a heterodimeric transmembrane receptor complex consisting of IL-17RC and IL-17RA subunits. While IL-17A is linked to the pathogenesis of diverse autoimmune and inflammatory diseases, it also plays an essential role in host defense against extracellular bacteria and fungi.IL-17A has been implicated in the pathogenesis of autoimmune diseases such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), psoriasis and experimental autoimmune encephalomyelitis (EAE). Psoriasis is a chronic inflammatory skin disorder characterized by dermal hyperplasia. The key histological features of psoriatic skin are epidermal keratinocyte hyperproliferation, vascular proliferation and infiltration of dendritic cells, macrophages, neutrophils and T cells. Cells in psoriatic skin lesions are reported to have increased expression of IL-23, IL-22 and IL-17A. IL-17A has been shown to increase the expression of skin antimicrobial peptides including HBD-2, psoriasin (S100A7) and calprotectin (S100A8/9) in keratinocytes. This is in keeping with the observation that psoriasis patients are more resistant to skin infections than the general population, perhaps as a result of elevated antimicrobial peptide production. While IL-17F is also an inducer of antimicrobial genes in keratinocytes, it is not as potent as IL-17A.IL-17A has also been shown to increase the expression of a number of CXC chemokines such as CXCL-1, CXCL-3, CXCL-5 and IL-8. CXC chemokines are neutrophil attractants while CCL20 preferentially attracts memory T cells and dendritic cells. Thus, IL-17A contributes to the psoriatic condition by increasing the influx of neutrophils, dendritic cells and memory T cells into the psoriatic lesion.

Products related to Role of IL-17A in Psoriasis

Explore products related to Role of IL-17A in Psoriasis
GeneGlobe ID: PAHS-021Z | Cat. No.: 330231 | RT2 Profiler PCR Arrays
RT² Profiler™ PCR Array Human Common Cytokines
RT2 Profiler PCR Array
Product Specification
GeneGlobe ID: PAHS-150Z | Cat. No.: 330231 | RT2 Profiler PCR Arrays
RT² Profiler™ PCR Array Human Cytokines & Chemokines
RT2 Profiler PCR Array
Product Specification
GeneGlobe ID: SBHS-150Z | Cat. No.: 249950 | QuantiNova LNA PCR Focus Panels
QuantiNova LNA PCR Focus Panel Human Cytokines & Chemokines
QuantiNova LNA PCR Focus Panel
Product Specification
GeneGlobe ID: UPHS-021Z | Cat. No.: 249955 | QuantiNova LNA Probe PCR Focus Panels
QuantiNova LNA Probe PCR Focus Panel Human Common Cytokines
QuantiNova LNA Probe PCR Focus Panel
Product Specification
GeneGlobe ID: UPHS-150Z | Cat. No.: 249955 | QuantiNova LNA Probe PCR Focus Panels
QuantiNova LNA Probe PCR Focus Panel Human Cytokines & Chemokines
QuantiNova LNA Probe PCR Focus Panel
Product Specification
GeneGlobe ID: SBHS-021Z | Cat. No.: 249950 | QuantiNova LNA PCR Focus Panels
QuantiNova LNA PCR Focus Panel Human Common Cytokines
QuantiNova LNA PCR Focus Panel
Product Specification

Didn't find what you're looking for?

Discover other products relevant to this gene list with our Panel Finder. Check it out.