Target List
Covers all exons in all known transcripts of targeted genes based on the Human GRCh37 / hg19 genome build
Oncogenes
ABL1, AKT1, AKT2, ALK, AR, BCL2, BRAF, CARD11, CBL, CDK4, CRKL, CRLF2 (TSLPR), CSF1R, CTNNB1, DNMT3A, EGFR (ERBB1), ERBB2 (HER-2, NEU), EZH2, FGFR2, FGFR3, FLT3, FOXL2, GATA2, GNA11, GNAQ, GNAS, H3-3A, H3C2, HRAS, IDH1, IDH2, IKBKE, JAK1, JAK2, JAK3, KIT (CD117), KRAS, MAP2K1, MED12, MET, MPL, MYD88, NFE2L2, NRAS, PDGFRA, PIK3CA (p110-alpha), PPP2R1A, PTPN11, REL, RET, SF3B1, SMO, SPOP, SRC, TSHR, U2AF1
Tumor Suppressor Genes
ACVR1B, AMER1, APC, ARID1A, ARID1B, ARID2, ARID5B, ASXL1, ASXL2, ATM, ATRX, AXIN1, B2M, BAP1, BARD1, BCOR, BRCA1, BRCA2, CDC73, CDH1 (E-Cadherin), CDKN2A (P16INK4A), CEBPA, CIC, CREBBP (CBP), CYLD, DAXX, EP300, FAT1, FBXW7, FLCN, FOXP1, FUBP1, GATA1, GATA3, HNF1A, KDM5C, KDM6A, KMT2C, KMT2D, MAP3K1 (MEKK1), MEN1, MLH1, NF1, NF2, NOTCH1, NOTCH2, NPM1, PAX5, PHF6, PIK3R1 (p85-ALPHA), PRDM1, PTCH1, PTEN, RB1, RNF43, RUNX1 (AML1), SMAD2 (MADH2), SMAD4 (MADH4), SMARCA4, SMARCB1, SOCS1, SOX9, STAG2, STK11 (LKB1), TET2, TNFAIP3, TP53 (p53), TSC1, TSC2, VHL, WT1, ZFHX3
Angiogenesis
AKT1, AKT2, AKT3, CTNNB1, ERBB2 (HER-2, NEU), FGFR2, FLT1 (VEGFR1), FLT4 (VEGFR2), GATA2, KDR (VEGFR3), NF1, NOTCH1, PIK3CA (p110-alpha), PTEN, PTGS2 (COX2), RUNX1 (AML1), TNFAIP3, VEGFA, VEGFD (VEGFD), VHL
Apoptosis
ABL1, ABL2 (ARG), AKT1, AKT2, AKT3, APC, ARAF, AXIN1, BCL2, BCL2L1 (BCLXL), BCL2L1 (BCLXL), BCL2L1 (BCLXL), BCL6, BRAF, CASP8 (FLICE), CBL, CDKN1A (p21CIP1, WAF1), CDKN2A (P16INK4A), CTNNA1, CTNNB1, CYLD, DAXX, FAS, FLT3, FOXL2, GATA1, HGF, HRAS, MAP2K4 (MKK4, JNKK1), MCL1, MDM4, MYCN, NF1, NPM1, PIM1, PRKCI, PTEN, RAD21, RAD50, RAD51, RAF1, RB1, REL, SOX9, STK11 (LKB1), TNF, TNFAIP3, TP73, VHL, WT1
Cell Adhesion Molecules
ABL1, ABL2 (ARG), APC, CDH1 (E-Cadherin), CTNNB1, DDR2, EGFR (ERBB1), EPCAM, ERBB2 (HER-2, NEU), FAT1, GATA1, JAK2, KDR (VEGFR3), NF1, NF2, NOTCH1, PDGFRA, PTEN, PTGS2 (COX2), PTPN11, RAC1, RET, RHOA, SRC, TSC1
Cell Cycle
ABL1, ABL2 (ARG), AKT1, AKT2, AKT3, APC, ATR, BLM, BRD4, CCND1, CCND2, CCND3, CCNE1, CDC27, CDC73, CDK12, CDK4, CDK6, CDK8, CDKN1A (p21CIP1, WAF1), CDKN1B (P27KIP1), CDKN2A (P16INK4A), CDKN2B (p15INK4b), CDKN2C (p18-INK4C), CHEK1, CHEK2 (RAD53), CREBBP (CBP), CUX1, CYLD, FBXW7, FGFR2, HRAS, MYC, NPM1, PIM1, PTEN, PTPRD, RAD21, RAD50, RAD51, RB1, RHEB, RHOA, SMARCA4, SMARCB1, SMC1A, SMC3, SOX2, SOX9, STAG2, STK11 (LKB1), TNFAIP3, TP53 (p53), TP53BP1, TSC1, WEE1, XPO1, ZFHX3
DNA Damage & Repair
ABL1, ABL2 (ARG), APC, ATM, ATR, ATRX, AXIN2, BRCA1, BRCA2, BRIP1, CDKN1A (p21CIP1, WAF1), CHEK1, CHEK2 (RAD53), EP300, EPCAM, ERCC1, ERCC2 (XPD), ERCC3 (XPB), ERCC4, ERCC5, EXO1, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, GADD45A, HERC1, HMGB1, HMGN1, LIG1, LIG3, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MEN1, MLH1, MLH3, MRE11, MSH2, MSH3, MSH4, MSH5, MSH6, MTOR, MUTYH, NBN, NPM1, PALB2, PARP1 (ADPRT1), PCNA, PIK3C2B, PMS1, PMS2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE4, PRKCG, PRKCZ, PRKDC, RAD17, RAD18, RAD21, RAD50, RAD51, RAD51C, RFC1, RFC2, RFC3, RFC4, RFC5, RNASEH2A, RPA1, RPA2, RPA3, RPA4, SETD2, SIRT1, SMC1A, SMC3, SSBP1, STK11 (LKB1), TDG, TP53 (p53), TP53BP1, TP73, TREX1, TRRAP, XRCC5
Epigenetics
ARID1A, ARID1B, ARID2, ARID5B, ASXL1, ASXL2, ATRX, AURKA, AURKB, BCOR, BCORL1, BRD4, CHD4, CTCF, DICER1, DNMT3A, DOT1L, EED, EZH2, FOXA1, H3-3A, H3C2, IKZF1, KAT6A, KDM5A, KDM5C, KDM6A, KMT2A, KMT2C, KMT2D, NCOR1, NSD1, PBRM1, PHF6, PRDM1, RARA, RUNX1T1, SMARCA4, SMARCB1, SPOP, SUZ12, TET2, TRRAP
Hypoxia Signaling
CREBBP (CBP), EP300, NF1, PDK1, SMAD4 (MADH4), VHL
Immune Response
ALK, B2M, BTK, CARD11, CD274 (PD-L1), CD274 (PD-L1), CD276, CD79A, CD79B, CREBBP (CBP), CRLF2 (TSLPR), CYLD, EP300, FAM46C, IL7R, IRF4, JAK1, JAK2, JAK3, MAP2K1, MAP2K2 (MEK2), MAP3K1 (MEKK1), MCL1, MYD88, NFKBIA (IκBα, MAD3), PAX5, PIK3CA (p110-alpha), PIK3R1 (p85-ALPHA), PTEN, PTPN11, REL, TNFAIP3, TNFRSF14, TP53 (p53)
Inflammatory Response
CEBPA, CSF1R, JAK2, MYD88, PTGS2 (COX2), REL
Metabolism
AKT1, AKT2, AKT3, ASXL2, FH, FLCN, IDH1, IDH2, MTOR, PDK1, PTGS2 (COX2), RICTOR, RPTOR, SDHA, SDHB, SDHC, SDHD, TNF, TSC2
RNA Splicing
DDX3X, QKI, RBM10, SF3B1, SMC1A, U2AF1
Signal Transduction
ACVR1B, AKT1, AKT2, AKT3, ALK, AMER1, APC, AXIN1, AXL, CBFB, CDKN1A (p21CIP1, WAF1), CNKSR1, CSF1R, CYLD, DDR2, DNER, EGFR (ERBB1), EPHA3, EPHA5, EPHA7, EPHB1, ERBB2 (HER-2, NEU), ERBB3, ERBB4, ERRFI1, EWSR1, FBXW7, FGF19, FGF3, FGF4, FGFBP1, FGFR1, FGFR2, FGFR3, FGFR4, FLT1 (VEGFR1), FLT3, FLT4 (VEGFR2), GABRA6, GATA2, GLI1, GNA11, GNA13, GNAQ, GNAS, GRIN2A, GSK3B, HGF, HNF1A, IGF1R, IGF2, IGF2R, IKBKE, INPP4B, IRF6, IRS2, JAK1, JAK2, JAK3, KDR (VEGFR3), KIT (CD117), KRAS, LMO1, LPAR2, MAP2K1, MAP2K2 (MEK2), MAP3K1 (MEKK1), MED12, MET, NF1, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NRAS, NTRK1, NTRK2, NTRK3, PDGFRA, PDGFRB, PIK3CA (p110-alpha), PIK3CB, PIK3CG, PIK3R1 (p85-ALPHA), PIK3R2 (p85-BETA), PLCG2, PPP2R1A, PRKAR1A, PRKCI, PTCH1, PTEN, PTPN11, RAF1, RASA1, RET, RIT1, RNF43, ROS1, SMAD2 (MADH2), SMAD3 (MADH3), SMAD4 (MADH4), SMO, SOCS1, SOS1, SOX17, SOX2, SPEN, SRC, STAT3, SUFU, SYK, TCF7L2, TGFBR2, TNF, TNKS (TIN1), TRRAP, TSC2, TSHR
Transcription Factors
AR, CEBPA, CIC, CUX1, ERG, ESR1 (ERα), ETV6, FBXW7, FOXA1, FOXL2, FOXP1, FUBP1, GATA1, GATA2, GATA3, GATA4, GATA6, GLI1, HNF1A, IRF4, IRF6, JUN, KEAP1, LZTR1, MEF2B, MEN1, MITF, MYB, MYC, MYCL, MYCN, MYOCD, NFE2L2, NKX2-1, PAX5, RB1, RUNX1 (AML1), SMAD2 (MADH2), SMAD3 (MADH3), SMAD4 (MADH4), SOX10, SOX17, SOX2, SOX9, TBX3, TCF7L2, TP53 (p53), TP73, WT1, ZFHX3, ZNF217
Ubiquitination
ASXL2, BAP1, BCOR, CDC27, CUL3, CUL4B, DAXX, MDM2, PRKN, RNF43
Unfolded Protein Response
HSP90AA1, NFE2L2, NPM1
Major Histocompatibility Complex Genes
B2M, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HLA-G, MR1
Antigen Presentation
ABCB9, ACE2, CALR, CANX, CTSB, CTSL, CTSS, ERAP1, ERAP2, IDE, IFI30, LGMN, LNPEP, NPEPPS, NRD1, PDIA3, PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMA8, PSMB1, PSMB10, PSMB11, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9, PSMC1, PSMC2, PSMC3, PSMC4, PSMC5, PSMC6, PSMD1, PSMD10, PSMD11, PSMD12, PSMD13, PSMD14, PSMD2, PSMD3, PSMD4, PSMD5, PSMD6, PSMD7, PSMD8, PSMD9, PSME1, PSME2, PSME3, PSME4, PSMF1, PSMG1, PSMG2, PSMG3, PSMG4, TAP1 (ABCB2), TAP2 (ABCB3), TAPBP, TAPBPL, TOP1, TPP2
Immune Checkpoint Molecules
VSIR, CD200, CD274 (PD-L1), CD274 (PD-L1), CD276, CD40 (TNFRSF5), CD40LG, CD48, CD70, CD80, CD86, ICOSLG, ITGAV, ITGB3, LGALS9, MICA, MICB, PDCD1LG2, TNFRSF14, TNFRSF9, TNFSF14, TNFSF18, TNFSF4 (OX40L), TNFSF9, VTCN1
Other Cancer-Related Genes
ALPK2, COL5A1, DIS3, DMD, FKBP9, KEL, LRP1B, MORC4, MUC17, TCP11L2, TERC, TERT, TOP1