Target List
Brain Cancers
Anaplastic Glial Tumors
CDKN2A (P16INK4A), CDKN2B (p15INK4b), MDM2, PTEN, RB1, TP53 (p53)
Astrocytomas
ATRX, BRAF, CHEK2 (RAD53), FGFR1, IDH1, IDH2, KRAS, NOTCH1, PTPN11, RB1, TP53 (p53)
Ependymomas
CDKN2A (P16INK4A), CDKN2B (p15INK4b), H3-3A, NF2, NOTCH1
Glioblastomas
ALK, APC, BCOR, BRAF, CDK4, CDK6, CDKN2A (P16INK4A), CDKN2B (p15INK4b), CREBBP (CBP), EGFR (ERBB1), ERBB2 (HER-2, NEU), FGFR3, H3-3A, H3C2, IDH1, IDH2, KIT (CD117), MDM2, MET, MLH1, MSH2, MTOR, MYC, NOTCH1, NRAS, PIK3CA (p110-alpha), PMS2, PTEN, RB1, STK11 (LKB1), TERT, TP53 (p53)
Gliomas
ACVR1 (ALK2), BRCA2, CHEK2 (RAD53), FGFR1, H3-3A, PDGFRA, PIK3CA (p110-alpha), PTEN, TP53 (p53)
High-Grade Gliomas
ATRX, BRAF, CIC, EGFR (ERBB1), FUBP1, IDH1, IDH2
Medulloblastomas
BRCA2, CDK4, CREBBP (CBP), CTNNB1, FGFR1, GLI2, IDH1, IDH2, MSH2, MYC, MYCN, NRAS, PIK3CA (p110-alpha), PTCH2, SMARCA4, SMARCB1, SUFU, TP53 (p53)
Meningiomas
CDKN2A (P16INK4A), CDKN2B (p15INK4b), NF2, PTEN
Oligodendrogliomas
IDH1, IDH2, MSH2, NOTCH1, TERT
Breast Cancers
Carcinomas
ATM, BARD1, BRCA1, BRCA2, BRIP1, CDK12, CDK4, CHEK1, CHEK2 (RAD53), EGFR (ERBB1), ERBB2 (HER-2, NEU), ESR1 (ERα), FANCL, KIT (CD117), KRAS, MET, MLH1, MLH3, MSH2, MSH3, MSH6, PALB2, PDGFRA, PIK3CA (p110-alpha), PMS1, PMS2, RAD51B, RAD51C, RAD51D, RAD54L
Ductal Carcinomas
AR, CCND1, CDH1 (E-Cadherin), CYP2D6, FANCD2, FBXW7, FGFR1, FGFR2, MRE11, MYC, NBN, NTRK3, PPM1D, PPP2R1A, RB1CC1, SF3B1, SLC22A18, STK11 (LKB1), TP53 (p53)
ER-Positive Carcinomas
CDH1 (E-Cadherin), RB1CC1, SF3B1
HER-Positive Carcinomas
AR, CCND1, FANCD2, NTRK3, PPM1D, RB1CC1
Metastatic Breast Cancers
AKT1, BRCA1, BRCA2, ERBB2 (HER-2, NEU), ERBB3, ESR1 (ERα), MDM2, NF1, PALB2, PIK3CA (p110-alpha), PTEN
Mismatch Repair (MMR) Genes
MLH1, MSH2, MSH6, PMS2
Colorectal Cancers
Adenocarcinomas
APC, ARID1A, ATM, AXIN2, BARD1, BAX, BMPR1A (ALK3), BRAF, BRCA1, BRCA2, BRIP1, BUB1, BUB1B, CDK12, CDKN2A (P16INK4A), CHEK1, CHEK2 (RAD53), CTNNB1, DCC, DLC1, EGFR (ERBB1), EP300, ERBB2 (HER-2, NEU), ERBB3, ESR1 (ERα), FANCL, FBXW7, FGFR1, FGFR3, FLCN, GNAS, HRAS, KIT (CD117), KRAS, MAP2K1, MCC, MET, MLH1, MLH3, MSH2, MSH3, MSH6, MUTYH, MYC, NRAS, PALB2, PDGFRA, PDGFRL, PMS1, PMS2, POLD1, POLE, PTEN, PTPN12, PTPRJ, RAD51B, RAD51C, RAD51D, RAD54B, RAD54L, RET, RNF43, SMAD4 (MADH4), SOX9, SRC, STK11 (LKB1), TCF7L2, TGFBR2, TP53 (p53)
Metastatic Colorectal Cancers
AKT1, ATM, BRAF, ERBB2 (HER-2, NEU), KRAS, MET, NRAS, PIK3CA (p110-alpha)
Mismatch Repair (MMR) Genes
EPCAM, MLH1, MSH2, MSH6, PMS2
Other Colorectal Cancer Genes
DPYD, ERCC1, TYMS, UGT1A1
Lung Cancers
Adenocarcinomas
ABL1, AKT1, ALK, ATM, BRAF, CCND1, CD274 (PD-L1), CD274 (PD-L1), CDK4, CDKN2A (P16INK4A), CTNNB1, DDR2, EGFR (ERBB1), ERBB2 (HER-2, NEU), FGFR1, FGFR3, HRAS, KRAS, MAP2K1, MAP3K8, MET, MYC, MYCN, NRAS, NTRK1, PIK3CA (p110-alpha), PPP2R1B, PRKN, PTEN, RET, ROS1, SLC22A18, STK11 (LKB1), TP53 (p53), TSC2
Malignant Pleural Mesotheliomas
BAP1, NF2
Non-Small Cell Lung Cancers (NSCLC)
AKT1, ALK, ATM, BARD1, BRAF, BRCA1, BRCA2, BRIP1, CCND1, CDK12, CDK4, CDKN2A (P16INK4A), CHEK1, CHEK2 (RAD53), CTNNB1, EGFR (ERBB1), ERBB2 (HER-2, NEU), FANCL, FGFR3, HRAS, IDH1, IRF1, KIT (CD117), KRAS, MAP2K1, MET, MLH1, MLH3, MSH2, MSH3, MSH6, MYC, NRAS, PALB2, PDGFRA, PIK3CA (p110-alpha), PMS1, PMS2, PTEN, RAD51B, RAD51C, RAD51D, RAD54L, RET, ROS1, TP53 (p53)
Small Cell Lung Cancers (SCLC)
CD274 (PD-L1), CD274 (PD-L1), HRAS, MYC, MYCN, NTRK1, PIK3CA (p110-alpha), PPP2R1B, PTEN, RB1, TP53 (p53)
Squamous Cell Carcinomas
BRAF, CD274 (PD-L1), CD274 (PD-L1), CDKN2A (P16INK4A), DDR2, EGFR (ERBB1), FGFR1, FGFR3, HRAS, MAP3K8, MYC, MYCN, NTRK1, PIK3CA (p110-alpha), PPP2R1B, PTEN, SLC22A18, TP53 (p53), TSC2
Myeloid Neoplasms
Acute Lymphoblastic Leukemia (ALL)
ABL1, ABL2 (ARG), BIRC3 (c-IAP2), BRAF, BTK, CDKN2A (P16INK4A), CDKN2B (p15INK4b), CREBBP (CBP), CRLF2 (TSLPR), EBF1, EP300, ETV6, FBXW7, FLT3, GATA3, HRAS, IKZF1, IL7R, JAK1, JAK2, JAK3, KDM6A, KMT2A, KRAS, MYC, NOTCH1, NRAS, PAX5, PDGFRB, PLCG2, PTEN, PTPN11, RUNX1 (AML1), SF3B1, SH2B3, TP53 (p53)
Acute Myeloid Leukemia (AML)
ANKRD26, ASXL1, ATRX, BRCA1, BRCA2, CBFB, CBLB, CBLC, CCND2, CDC25C, CEBPA, CUX1, DCK, DDX41, DHX15, DNMT3A, ELANE, ETV6, FLT3, GATA1, GATA2, GNAS, HRAS, IDH1, IDH2, IKZF1, IKZF2, IKZF3, JAK2, KDM6A, KIT (CD117), KMT2A, KRAS, LUC7L2, MTOR, NPM1, NRAS, NUP214, PDGFRA, PICALM, PRPF8, PTPN11, RB1, RBBP6, RPS14, RUNX1 (AML1), SF3B1, SLC29A1, SMC1A, TERT, TET1, TET2, TP53 (p53), U2AF1, U2AF2, WT1, ZEB2
Acute Promyelocytic Leukemia (APML; APL)
CEBPA, NPM1, NUMA1, RARA, RUNX1 (AML1)
Atypical Chronic Myeloid Leukemia (aCML)
ASXL1, CBL, CEBPA, EZH2, FLT3, JAK2, KRAS, NPM1, NRAS, RUNX1 (AML1), SETBP1, SRSF2, TET2, U2AF1
Chronic Lymphocytic Leukemia (CLL)
ATRX, BCL2, BIRC3 (c-IAP2), BRAF, CBLB, CCND2, CD38, CUX1, GNAS, GNB1, LUC7L2, MYD88, NOTCH1, NRAS, PTPN11, SF3B1, TP53 (p53), U2AF2, XPO1, ZAP70
Chronic Myeloid Leukemia (CML)
ABL1, ASXL1, BCOR, BCR, BRAF, CBL, CREBBP (CBP), DNMT3A, DNMT3B, EZH2, IDH1, IDH2, IKZF1, JAK2, KRAS, NPM1, NRAS, RUNX1 (AML1), TET1, TET2, TP53 (p53), WT1
Chronic Myelomonocytic Leukemia (CMML)
ASXL1, BCOR, BCORL1, CBL, CEBPA, DNMT3A, EZH2, FLT3, IDH1, IDH2, JAK2, KIT (CD117), KRAS, MPL, NF1, NPM1, NRAS, PHF6, PTPN11, RUNX1 (AML1), SETBP1, SF3B1, SRSF2, STAG2, TET2, TP53 (p53), U2AF1, ZRSR2
Hairy Cell Leukemia
BRAF, CDKN1B (P27KIP1), MAP2K1, TP53 (p53)
Juvenile Myelomonocytic Leukemia
ARHGAP26, CBL, KRAS, NRAS, PTPN11
Acute Lymphocytic Lymphomas
BIRC3 (c-IAP2), BTK, CDKN2A (P16INK4A), CDKN2B (p15INK4b), MYC, NOTCH1, PLCG2, SF3B1, TP53 (p53)
B Cell Lymphomas
BCL6, BRAF, CD79A, CHEK2 (RAD53), EZH2, MAP2K1, MYD88, STAT6, TNFRSF14, TP53 (p53)
Burkitt Lymphomas
CBLB, GNA13, H1-4, MTOR, MYC
Diffuse Large B Cell Lymphomas
B2M, BCL2, CBLB, GNA13, H1-4, KMT2D, MTOR, PIM1, PRPF8, SOCS1, TNFAIP3
Follicular Lymphomas
ARID1A, BCL10, BCL2, CARD11, CREBBP (CBP), EP300, EZH2, FOXO1, KMT2D, MEF2B
Mantle Cell Lymphomas
ATM, CCND1
Marginal Zone Lymphomas
KLF2, MYD88, NOTCH2, TNFAIP3, TP53 (p53)
Mucosa-Associated Lymphoid Tissue (MALT) Lymphomas
BCL10, TNFAIP3
Non-Hodgkin Lymphomas
BRAF, CASP10 (MCH4), NRAS, PIK3CA (p110-alpha), RAD54B, RAD54L, TP53 (p53)
Primary Cutaneous Lymphomas
CD79B, MYD88
Small Lymphocytic Lymphomas
ATRX, BCL2, CBLB, CCND2, CUX1, GNAS, LUC7L2, U2AF2, XPO1
T Cell Lymphomas
ARID1B, ATM, CBLB, CCR4, DNMT3A, IDH1, IDH2, INO80, JAK1, JAK3, RHOA, SETD2, STAT3, STAT5B, TET2
Myelodysplastic Syndromes
ANKRD26, ASXL1, ATRX, BCOR, BCORL1, CALR, CBL, CEBPA, CSF3R (GM-CSFR), CUX1, DDX41, DKC1, DNMT3A, ETNK1, ETV6, EZH2, FLT3, GATA2, GNAS, GNB1, IDH1, IDH2, JAK2, JAK3, KIT (CD117), KRAS, MPL, NF1, NPM1, NRAS, PHF6, PIGA, PPM1D, PTPN11, RAD21, RUNX1 (AML1), SAMD9, SAMD9L, SETBP1, SF3B1, SMC3, SRP72, SRSF2, STAG2, STAT3, TERC, TERT, TET2, TP53 (p53), U2AF1, WT1, ZRSR2
Myeloproliferative Neoplasms
ASXL1, BCOR, CALR, CBL, CSF3R (GM-CSFR), DNMT3A, ETV6, EZH2, IDH1, IDH2, JAK2, KIT (CD117), MPL, NOTCH1, NRAS, PDGFRA, RUNX1 (AML1), SETBP1, SF3B1, SH2B3, SRSF2, STAT3, STAT5B, TET2, TP53 (p53), U2AF1, ZRSR2
Essential Thrombocythemia
ASXL1, CBL, IDH2, JAK2, MPL, SF3B1, TET2, TP53 (p53)
Multiple Myeloma
ATM, BARD1, BRAF, BRCA1, BRCA2, BRIP1, CHEK1, CHEK2 (RAD53), CXCR4, EGFR (ERBB1), ERBB2 (HER-2, NEU), FANCL, FGFR3, IDH1, IDH2, KIT (CD117), KRAS, MET, NRAS, PALB2, PDGFRA, RAD51B, RAD51C, RAD51D, RET, TP53 (p53)
Plasma Cell Myeloma
HRAS, MTOR, RB1, SLC29A1
Polycythemia Vera
ASXL1, DNMT3A, EZH2, IDH1, JAK2, NRAS, TET2, TP53 (p53)
Primary Myelofibrosis
ASXL1, CBL, DNMT3A, EZH2, IDH1, IDH2, JAK2, MPL, NF1, NRAS, SETBP1, SF3B1, SRSF2, TET2, TP53 (p53)
Systemic Mastocytosis
ASXL1, CBL, DNMT3A, ETV6, EZH2, IDH2, JAK2, KIT (CD117), KRAS, NPM1, NRAS, RUNX1 (AML1), SETBP1, SF3B1, SRSF2, TET2, TPSAB1, U2AF1
Waldenstrom Macroglobulinemia
CXCR4, MYD88
Ovarian Cancers
Endometrioid Carcinomas
CDKN2A (P16INK4A), CTNNB1, FANCF, POLE, PPP2R1A
Epithelial Carcinomas
ABRAXAS1, ARID1A, ATM, BARD1, BRAF, BRCA1, BRCA2, BRIP1, CCNE1, CDK12, CHEK1, CHEK2 (RAD53), ERBB2 (HER-2, NEU), ERCC1, KRAS, MRE11, NBN, NF1, PALB2, PIK3CA (p110-alpha), PTEN, RAD51B, RAD51C, RAD51D, RB1, TP53 (p53), WT1
Granulosa Cell Tumors
AKT1, FOXL2
Mixed Adenosquamous Carcinomas
AKT1, ATR, ATRX, BLM, CCND1, CCND2, CCNE1, CDH1 (E-Cadherin), DICER1, ERBB3, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCI, FANCL, FANCM, FBXW7, FGFR1, FGFR2, FGFR3, KIT (CD117), MYC, OPCML (OBCAM), PDGFRA, PIK3R1 (p85-ALPHA), POLE, PRKN, RAD50, RAD51, RAD52, RAD54L, RB1, RPA1, SMARCA4, STK11 (LKB1)
Mucinous Carcinomas
ATRX, CDKN2A (P16INK4A), ERBB3, PDGFRA
Serous Carcinomas
ATR, ATRX, BLM, CCND1, CCND2, CCNE1, CDH1 (E-Cadherin), CDKN2A (P16INK4A), DICER1, ERBB3, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, FANCI, FANCL, FANCM, FBXW7, FGFR1, FGFR2, FGFR3, KIT (CD117), MYC, PPP2R1A, RAD50, RAD51, RAD52, RAD54L, RB1, RPA1, SMARCA4
Mismatch Repair (MMR) Genes
MLH1, MSH2, MSH6, PMS2
Pancreatic Cancers
Adenocarcinomas
ATM, CDKN2A (P16INK4A), CFTR, FANCC, FANCG, MLH1, MSH2, MSH6, PALB2, PALLD, PMS2, PRSS1, SMAD4 (MADH4), SPINK1, STK11 (LKB1), TP53 (p53)
Advanced Ductal Adenocarcinomas
BRAF, BRCA1, BRCA2, ERBB2 (HER-2, NEU), KRAS, MDM2, PIK3CA (p110-alpha)
Ductal Carcinomas
APC, ARID1A, CDK6, CTNNB1, ERBB3, FBXW7, FGFR1, GNAS, KDM6A, KRAS, MET, MYC, NRAS, PIK3R3, POLE, PREX2, PTCH1, PTEN, RNF43, ROBO2, SLC29A1, SOX9, TCF7L2
Mismatch Repair (MMR) Genes
MLH1, MSH2, MSH6, PMS2
Prostate Cancers
Adenocarcinomas
ABRAXAS1, APC, AR, ATR, BARD1, BRAF, BRIP1, CDK12, CHEK1, CHEK2 (RAD53), EPHB2, ERG, ETV1, ETV4, ETV5, FANCA, FANCL, FGFR1, FOXA1, GEN1, HRAS, IDH1, KDM6A, KLF6, KMT2D, KRAS, MAD1L1, MED12, MRE11, MXI1, MYC, NBN, PIK3R1 (p85-ALPHA), PPP2R2A, PTEN, RAD51B, RAD51C, RAD51D, RAD54L, RAF1, RB1, SPOP, TP53 (p53), ZFHX3
Advanced Prostate Cancers
AKT1, ATM, BRCA1, BRCA2, PALB2, PIK3CA (p110-alpha), PTEN
Ductal Carcinomas
CTNNB1
Mismatch Repair (MMR) Genes
MLH1, MSH2, MSH6, PMS2