Target List
Beta-Amyloid Generation, Oligomerization, Clearance & Degradation
Secretases
Adam9, Aph1a, Bace1, Bace2, Ctsb, Ncstn, Psen1, Psen2
Other Peptidases
Ide, Plat (tPA), Plau (UPAM), Plg
Beta-Amyloid Clearance Through Endocytosis
App, Lrp1, Lrp6
Other Beta-Amyloid Metabolism Genes
Ache, Apbb1, Apbb2, Apoe, Bche, LOC100911545 (A2m), Ubqln1
Cytoskeleton Regulators
Apoe, Map2, Mapt, Pkp4, Prkci
Synaptic Formation
Synaptic Transmission
Apba1 (Mint1), Apoe, Chat
Other Synaptic Functions
Ache, Apba1 (Mint1), Apbb1, Apbb2, Apoe, Bdnf
Cholesterol Metabolism
Abca1, Apoa1, Apoe
Lipid & Lipoprotein Metabolism
Apoa1, Apoe, Clu, Hsd17b10, Igf2, Il1b, Ins2, Lpl, Lrp1, Sncb
Hormone & Hormone Processing
Bace2, Igf2, Ins2
Apoptosis
Induction of Apoptosis
Apoe, Casp3, Casp4, Ppp3cc, Prkca, Prkce
Anti-Apoptotic
Il1a, Il1b, Mpo, Prkcz, Psen1, Snca
Other Apoptosis Genes
App, Clu, Ep300 (QuantiNova Symbol: AABR07058539.1), Mapt, Nae1, Psen2
Cell Cycle
Cell Cycle Arrest
Apbb1, Apbb2
Other Cell Cycle Genes
Apbb1, Apbb2, Cdk1, Cdk5, Cdkl1, Ep300 (QuantiNova Symbol: AABR07058539.1), Il1a, Nae1, Prkca
Protein Kinases
Cdk1, Cdk5, Cdkl1, Gsk3a, Gsk3b, Insr, Prkca, Prkcb, Prkcd, Prkce, Prkcg, Prkci, Prkcq, Prkcz
Cell Signaling Molecules
WNT Signaling
Gsk3b, Lrp6
Notch Signaling
Aph1a, Ncstn, Psen1, Psen2
G-Protein Coupled Receptor Signaling
Aplp2, Gnao1, Gnaz, Gnb1, Gnb2, Gnb4, Gnb5, Gng10, Gng11, Gng5, Gng7, Gng8
Intracellular Signaling
Apba3, Apbb2, Prkca, Prkcb, Prkcd, Prkce, Prkcg, Prkci, Prkcq, Prkcz, Psen1, Psen2
Other Cell Signaling Molecules
Gap43, Gnb2, Ide, Il1a, Il1b, Insr, Nae1, Plau (UPAM)
Transcriptional Regulation
Apbb1, Apbb2, Ep300 (QuantiNova Symbol: AABR07058539.1)
Other Alzheimer's Disease Genes
Oxidoreductases & Oxidative Stress
Hsd17b10, Mpo, Mt3, Ndufb8, Uqcrc1, Uqcrc2
Proteases
Capn1, Ctsc, Ctsd, Ctsg, Ctsl, Uqcrc2
Protease Inhibitors
Aplp2, App, LOC299282 (QuantiNova Symbol: Serpina3n), Serpina3c