Vangl2 Gene Summary [Mouse]
Involved in several processes, including Wnt signaling pathway, planar cell polarity pathway; axon guidance; and morphogenesis of an epithelium. Acts upstream of or within several processes, including inner ear development; morphogenesis of an epithelium; and ventricular septum morphogenesis. Located in several cellular components, including basolateral plasma membrane; lateral plasma membrane; and stress fiber. Is active in glutamatergic synapse and postsynaptic density membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system epithelium; and sensory organ. Used to study neural tube defect. Human ortholog(s) of this gene implicated in neural tube defect. Orthologous to human VANGL2 (VANGL planar cell polarity protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Vangl2 |
| Official Name | VANGL planar cell polarity 2 [Source:MGI Symbol;Acc:MGI:2135272] |
| Ensembl ID | ENSMUSG00000026556 |
| Bio databases IDs | |
| Aliases | VANGL planar cell polarity 2 |
| Synonyms | C530001F03RIK, loop-tail, Lootl, Lp, LPP1, LTAP, ska17, ska<m17Jus>, STB1, STBM, STBM1, strabismus, Vang1l2, VANGL planar cell polarity 2, VANGL planar cell polarity protein 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Vangl2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Strabismus protein
- cytoplasmic domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neural tube defect
- hearing loss
- hypoplasia
- chronic lymphocytic leukemia
- spina bifida
- preeclampsia
- multiple sclerosis
- eyelids open at birth
- craniorachischisis
- disorder of pregnancy
phenotypes
- abnormal snout morphology
- abnormal tail movements
- curly tail
- decreased circulating HDL cholesterol level
- decreased circulating cholesterol level
- increased circulating glucose level
- kinked tail
- aberrant origin of the right subclavian artery
- abnormal aortic arch morphology
- abnormal body wall morphology
- abnormal brain development
- abnormal brain morphology
- abnormal brain ventricle morphology
- abnormal brain ventricular system morphology
- abnormal branching involved in lung morphogenesis
- abnormal cerebral hemisphere morphology
- abnormal cervical flexure morphology
- abnormal cochlea morphology
- abnormal cochlear hair cell morphology
- abnormal cochlear inner hair cell morphology
- abnormal cochlear outer hair cell morphology
- abnormal corpus callosum morphology
- abnormal costovertebral joint morphology
- abnormal digestive system development
- abnormal dorsal striatum morphology
- abnormal ear development
- abnormal embryo development
- abnormal embryo turning
- abnormal embryonic neuroepithelium morphology
- abnormal embryonic tissue morphology
- abnormal forebrain development
- abnormal forebrain morphology
- abnormal head movements
- abnormal heart development
- abnormal heart looping
- abnormal hindbrain morphology
- abnormal hippocampus morphology
- abnormal inner ear morphology
- abnormal lateral ventricle morphology
- abnormal left subclavian artery morphology
- abnormal locomotor behavior
- abnormal lung epithelium morphology
- abnormal lung lobe morphology
- abnormal lung morphology
- abnormal lung saccule morphology
- abnormal metencephalon morphology
- abnormal midbrain development
- abnormal midbrain morphology
- abnormal motor capabilities/coordination/movement
- abnormal neural plate morphology
- abnormal neural tube closure
- abnormal neural tube morphology
- abnormal notochord morphology
- abnormal organ of Corti morphology
- abnormal orientation of cochlear hair cell stereociliary bundles
- abnormal orientation of inner hair cell stereociliary bundles
- abnormal orientation of outer hair cell stereociliary bundles
- abnormal otic pit morphology
- abnormal otic vesicle development
- abnormal primitive streak morphology
- abnormal respiratory conducting tube morphology
- abnormal rib development
- abnormal rib morphology
- abnormal semicircular canal morphology
- abnormal somite development
- abnormal somite shape
- abnormal somite size
- abnormal sternebra morphology
- abnormal sternocostal joint morphology
- abnormal sternum morphology
- abnormal sternum ossification
- abnormal tail morphology
- abnormal ventral body wall morphology
- abnormal vertebrae morphology
- abnormal vertebral arch development
- abnormal vertebral arch morphology
- abnormal vertebral body morphology
- abnormal vertebral epiphyseal plate morphology
- abnormal vestibular hair cell morphology
- abnormal xiphoid process morphology
- common truncal valve
- craniorachischisis
- decreased cochlear coiling
- decreased embryo size
- decreased fetal size
- decreased rib number
- decreased vertical activity
- delayed neural tube closure
- dilated endolymphatic sac
- dilated terminal bronchiole tubes
- double aortic arch
- double outlet right ventricle
- enlarged floor plate
- enlarged lateral ventricles
- enlarged third ventricle
- eyelids open at birth
- failure of eyelid fusion
- female infertility
- fetal growth retardation
- fused somites
- fusion of vertebral arches
- head shaking
- hemorrhage
- impaired balance
- impaired branching involved in terminal bronchiole morphogenesis
- imperforate hymen
- incomplete embryo turning
- increased cochlear hair cell number
- increased cochlear outer hair cell number
- inner ear hypoplasia
- lethality complete penetrance
- male infertility
- neonatal lethality incomplete penetrance
- omphalocele
- open neural tube
- perinatal lethality complete penetrance
- prenatal lethality complete penetrance
- preweaning lethality incomplete penetrance
- pulmonary hypoplasia
- rib bifurcation
- rib fusion
- right aortic arch
- short scala media
- short tail
- short umbilical cord
- small lung
- small lung lobe
- spina bifida
- thick lung-associated mesenchyme
- vagina atresia
- vascular ring
- ventricular septal defect
- vertebral fusion
role in cell
- migration
- expression in
- phosphorylation in
- polarization
- transcription in
- differentiation
- interaction in
- assembly
- morphology
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- basal ectoplasmic specialization of blood-testis barrier
- apical ectoplasmic specialization
- glutaminergic synapse
- cell pole
- cell periphery
- cellular membrane
- intercellular junctions
- cell-cell contacts
- apical cytoplasm
- apical membrane
- synaptic membrane
- basolateral membrane
- lateral plasma membrane
- recycling endosomes
- early endosomes
- transport vesicles
- actin stress fibers
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Vangl2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neural tube closure
- apical protein localization
- establishment of planar polarity
- heart looping
- Wnt receptor signaling pathway, planar cell polarity pathway
- cell migration involved in kidney development
Cellular Component
Where in the cell the gene product is active
- lateral plasma membrane
- cell-cell junction
- plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding