Lrp6 Gene Summary [Mouse]
Enables Wnt-protein binding activity; apolipoprotein binding activity; and toxin transmembrane transporter activity. Involved in cell surface receptor signaling pathway; positive regulation of neuron projection development; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including central nervous system development; embryonic morphogenesis; and regionalization. Located in early endosome and plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Used to study neural tube defect and steatotic liver disease. Human ortholog(s) of this gene implicated in tooth agenesis. Orthologous to human LRP6 (LDL receptor related protein 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lrp6 |
| Official Name | low density lipoprotein receptor-related protein 6 [Source:MGI Symbol;Acc:MGI:1298218] |
| Ensembl ID | ENSMUSG00000030201 |
| Bio databases IDs | |
| Aliases | low density lipoprotein receptor-related protein 6 |
| Synonyms | ADCAD2, C030016K15RIK, CD, Gw, LDL receptor related protein 6, LOC100502826, Low-density lipoprotein receptor-related protein 6, ska26, ska<m26Jus>, skax26, STHAG7 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lrp6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Wnt-protein binding
- SMP-30/Gluconolactonase/LRE-like region
- frizzled binding
- kinase inhibitor activity
- Wnt receptor
- NHL repeat unit of beta-propeller proteins
- identical protein binding
- Wnt binding domain
- cytoplasmic domain
- intracellular domain
- LDLa
- toxin transporter
- transmembrane receptor
- Coagulation Factor Xa inhibitory site
- coreceptor
- extracellular domain
- beta propeller
- ectodomain
- protein binding
- receptor binding
- Low-density lipoprotein receptor repeat class B
- EGF-like domain
- PPPSP motif
- protein serine/threonine kinase inhibitor
- transmembrane domain
- protein homodimerization
- low-density lipoprotein receptor
- Low-density lipoprotein-receptor YWTD domain
Pathways
Biological processes and signaling networks where the Lrp6 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Colorectal Cancer Metastasis Signaling
- Factors Promoting Cardiogenesis in Vertebrates
- Gap Junction Signaling
- Molecular Mechanisms of Cancer
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- WNT/β-catenin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- Alzheimer disease
- fibrosis
- neoplasia
- Burkitt lymphoma
- hepatocellular carcinoma
- hereditary disorder
- liver cancer
- epithelial cancer
- selective tooth agenesis type 7
phenotypes
- abnormal brown adipose tissue morphology
- abnormal caudal vertebrae morphology
- abnormal cerebellum morphology
- abnormal coat appearance
- abnormal cranium morphology
- abnormal digit morphology
- abnormal dorsal-ventral polarity of the somites
- abnormal external female genitalia morphology
- abnormal external male genitalia morphology
- abnormal eye development
- abnormal fatty acid level
- abnormal forebrain development
- abnormal forebrain morphology
- abnormal forelimb morphology
- abnormal frontal bone morphology
- abnormal head morphology
- abnormal head movements
- abnormal head shape
- abnormal hindlimb morphology
- abnormal limb morphology
- abnormal lipid homeostasis
- abnormal liver morphology
- abnormal liver physiology
- abnormal lumbar vertebrae morphology
- abnormal midbrain morphology
- abnormal midbrain-hindbrain boundary morphology
- abnormal molar cusp morphology
- abnormal neural tube closure
- abnormal nose morphology
- abnormal orientation of outer hair cell stereociliary bundles
- abnormal outer ear morphology
- abnormal paraxial mesoderm morphology
- abnormal sacral vertebrae morphology
- abnormal somite development
- abnormal tail bud morphology
- abnormal tail ring morphology
- abnormal telencephalon morphology
- abnormal tooth development
- abnormal tooth eruption
- abnormal vertebrae development
- abnormal vertebrae morphology
- abnormal vertebral arch morphology
- absent apical ectodermal ridge
- absent inferior colliculus
- absent paraxial mesoderm
- absent vertebrae
- anophthalmia
- caudal vertebral fusion
- cleft palate
- cleft upper lip
- craniorachischisis
- curly tail
- decreased birth body size
- decreased body size
- decreased body weight
- decreased bone mineral density
- decreased circulating glucose level
- decreased embryo size
- decreased liver triglyceride level
- decreased molar number
- decreased somite size
- decreased susceptibility to diet-induced obesity
- decreased susceptibility to induced hypothermia
- delayed bone ossification
- delayed cranial suture closure
- embryonic lethality before implantation incomplete penetrance
- enlarged liver
- exencephaly
- failure of eyelid fusion
- forebrain hypoplasia
- fused dorsal root ganglion
- growth retardation of molars
- hemivertebra
- hepatic steatosis
- hyperlipidemia
- improved glucose tolerance
- incomplete somite formation
- increased brown fat cell number
- increased cholesterol level
- increased circulating LDL cholesterol level
- increased circulating VLDL triglyceride level
- increased circulating adiponectin level
- increased circulating aspartate transaminase level
- increased circulating bilirubin level
- increased circulating triglyceride level
- increased insulin sensitivity
- increased liver cholesterol level
- increased liver triglyceride level
- insulin resistance
- kinked tail
- liver fibrosis
- liver inflammation
- long upper incisors
- microphthalmia
- neonatal lethality complete penetrance
- neonatal lethality incomplete penetrance
- no abnormal phenotype detected
- oligodactyly
- osteoporosis
- perinatal lethality complete penetrance
- polydactyly
- postnatal growth retardation
- postnatal lethality incomplete penetrance
- prenatal lethality
- prenatal lethality incomplete penetrance
- protruding tongue
- retina coloboma
- rib fusion
- short incisors
- short limbs
- short tail
- sirenomelia
- small caudal vertebrae
- small cranium
- small lower incisors
- small molars
- small tail bud
- sparse hair
- spina bifida
- spina bifida cystica
- spina bifida occulta
- thin neurocranium
- vertebral fusion
role in cell
- expression in
- activity
- activation in
- migration
- phosphorylation in
- binding
- proliferation
- tyrosine phosphorylation in
- signaling in
- production in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- Extracellular Space
- perinuclear region
- cellular membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- caveolae
- endosomal membrane
- early endosomes
- cytoplasmic vesicles
- membrane rafts
- perikaryon
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lrp6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of smooth muscle cell apoptotic process
- transmembrane transport
- neural crest cell differentiation
- nervous system development
- positive regulation of cell cycle
- synaptic transmission
- endocytosis
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of sequence-specific DNA binding transcription factor activity
- response to peptide hormone stimulus
- elevation of cytosolic calcium ion concentration
- dopaminergic neuron differentiation
- positive regulation of transcription, DNA-dependent
- cellular response to cholesterol
- Wnt receptor signaling pathway
- canonical Wnt receptor signaling pathway
- negative regulation of protein serine/threonine kinase activity
- neural crest formation
- protein localization in plasma membrane
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- caveola
- early endosome
- cytoplasmic vesicle
- Golgi apparatus
- endoplasmic reticulum
- synapse
- neuronal cell body
- extracellular region
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- coreceptor activity
- identical protein binding
- frizzled binding
- Wnt-activated receptor activity
- protein binding
- protein homodimerization activity
- kinase inhibitor activity
- low-density lipoprotein receptor activity
- Wnt-protein binding
- toxin transporter activity
- receptor binding