Target List
Actin Filaments
Actin Filament Interacting Proteins
ACTR2, ACTR3, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, CALD1, CDC42EP3, CFL1, CYFIP1, CYFIP2, DIAPH1, DSTN, EZR, FSCN2, GSN, IQGAP2, MACF1, PFN2, RDX, SSH1, SSH2, VASP, WASF1, WASL
Actin Filament Organization & Biogenesis
ARFIP2, ARHGDIB, ARHGEF11, ARPC4, CASK, CDC42, CDC42BPA, ARAP1, CFL1, CRK, DIAPH1, DSTN, EZR, FSCN2, GSN, IQGAP1, LIMK1, LIMK2, NCK1, PFN2, RDX, RHOA, ROCK1, SSH1, SSH2
Actin Polymerization / Depolymerization
ACTR3, ARHGAP6, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, CDC42EP2, DSTN, FNBP1L, GSN, NCK1, NCK2, PFN2, PIKFYVE, RAC1, WAS, WASF1, WASL
Cortical Cytoskeleton
ARFIP2, CLASP1, CTTN, DSTN, EZR, LLGL1, MAPRE1
Microtubules
Microtubule Interacting Proteins
CLASP1, CLASP2, CLIP1, CLIP2, MACF1, MAP4, MAPRE1, MAPRE2, MAPT, MID1, RACGAP1, STMN1
Microtubule Organization & Biogenesis
CLASP1, MAPT, MID1, PHLDB2, STMN1
Microtubule Polymerization / Depolymerization
CLASP1, CLASP2, MAP4, MAPRE1, MAPRE2, MAPT, STMN1
Spindle Organization & Biogenesis
AURKA, AURKB, CLASP1, CLASP2, CLIP1, MAPRE1, RACGAP1
Cell Projections
Axons & Dendrites
BAIAP2, CDK5, CDK5R1, CYFIP1, CYFIP2, MAPT
Filopodia
BAIAP2, CDC42, CDK5, ARAP1, EZR, MSN, RDX
Growth Cones
CDK5, CDK5R1, MAPT
Lamellipodia
ACTR3, ARFIP2, ARPC5, CDK5, CTTN, CYFIP1, CYFIP2, NCK1, PPP1R12A (MYPT1), PPP1R12B, RAC1, RDX, WASL
Microvilli
EZR, MSN, RDX
Pseudopodia
CDC42, CDC42EP2
Ruffles
ARFIP2, CTTN, CYFIP1, CYFIP2, EZR, RAC1, RDX
Cell Shape, Size, Polarity & Morphogenesis
ARHGEF11, CDC42, CDC42EP2, CDC42EP3, ARAP1, CLASP1, CLASP2, CYFIP1, CYFIP2, EZR, LLGL1, MARK2, MYLK2, SSH1
Cell Motility & Migration
ACTR2, ACTR3, ARFIP2, ARHGDIB, ARHGEF11, ARPC1B, ARPC2, ARPC3, ARPC5, CALD1, CDK5, CDK5R1, ARAP1, DSTN, MSN, NCK1, PAK4, RAC1, ROCK1, WASF1, WASL
Cell Cycle & Cell Division
Mitosis
AURKA, AURKB, CCNA1, CCNB2, CIT, CLASP1, CLASP2, CLIP1, MAPRE1, MAPRE2
Cytokinesis
ARHGEF11, AURKB, AURKC, DSTN, RACGAP1, ROCK1
Cytoskeleton Adaptor Activity
BAIAP2, MSN, NCK1, NCK2, PAK1
Calmodulin / Calcineurin
CALD1, CALM1, CASK, IQGAP1, IQGAP2, MYLK, MYLK2, PPP3CA, PPP3CB
G-Protein Signaling
ARFIP2, ARHGAP6, ARHGDIB, ARHGEF11, CDC42, CDC42EP2, ARAP1, CFL1, CIT, CYFIP1, CYFIP2, DIAPH1, IQGAP1, IQGAP2, LIMK1, LIMK2, MAPK13 (p38delta), RAC1, RACGAP1, RHOA, ROCK1, TIAM1, WAS, WASL
Kinases & Phosphatases
AURKA, AURKB, AURKC, CASK, CDC42BPA, CDK5, CDK5R1, CIT, LIMK1, LIMK2, MAP3K11, MAPK13 (p38delta), MARK2, MYLK, MYLK2, PAK1, PAK4, PPP1R12A (MYPT1), PPP1R12B, PPP3CA, PPP3CB, ROCK1, SSH1, SSH2