Target List
Apoptosis
CASP1 (ICE), CCL2 (MCP-1), EGR3, IL1B, IL2RA (CD25), IL6, ITGB2, LCN2 (NGAL), SOD2, TNF
Inflammation
C3, CCL11 (Eotaxin), CCL2 (MCP-1), CCL20 (MIP-3A), CCL25 (TECK), CCL5 (RANTES), CCR1, CCR2, CCR5, CX3CL1, CXCL1 (GRO1, GROa, SCYB1), CXCL10 (INP10), CXCL11 (I-TAC, IP-9), CXCL2 (GRO2, GROb, SCYB2), CXCL3, CXCL9 (MIG), CXCR1, FPR1, IL13, IL17A, IL1B, IL2RA (CD25), IL23A, IL5, IL6, CXCL8 (IL8), ITGB2, LTB, LYZ, S100A8, S100A9, SAA1, SELE, STAT3, TNF
Immunity
Humoral Immunity
CCL2 (MCP-1), IL6, DEFA5, DEFA6, LYZ
Innate Immunity
C3, C4BPB, CASP1 (ICE), CD55, CR2, IL1RN, IRF5, ISG15, LCN2 (NGAL), NOD2, NOS2 (iNOS), SAA1, TYK2
Adaptive Immunity
CCL11 (Eotaxin), CCR2, CCR5, CCR9, CXCR3, HLA-DQA1, HLA-DRA, HLA-DRB1, IFNG, IL13, IL17A, IL2RA (CD25), IL5, IL6, IRF5, STAT1
Extracellular Matrix (ECM) & Cell Adhesion Molecules
CCL2 (MCP-1), CCR1, CCL11 (Eotaxin), CSTA, CX3CR1, CXCL12 (SDF1), CXCR3, ITGB2, MMP1, MMP10, MMP3, MMP7, PECAM1, SELE, SELL (LECAM-1), TIMP1, VWF
Unfolded Protein Response
HSP90B1, HSPA5 (GRP78), UBD
Digestive Secreted Proteins
GCG, MUC1 (mucin), REG1A, REG1B, TFF1 (pS2)
Metabolism
ALDOB, PCK1, TDO2
Other Crohn's Disease Genes
ABCB1 (MDR1, PGY1), ATG16L1, CHI3L1, EDN3, NR3C2