Target List
Notch Signaling
Notch Ligands
Notch1, Notch2, Notch3, Notch4
Notch Binding
Dll1 (Delta1), Dll3, Dll4, Dtx1, Jag1, Jag2, Lfng, Mfng, Numb, Rfng
Notch Receptor Processing
Adam10, Adam17 (Cd156b), Ncstn, Psen1, Psen2, Psenen
Transcription Factors & Cofactors
Ep300, Maml1, Maml2, Ncor2, Rbpjl, Snw1
Notch Target Genes
Apoptosis
Cflar (Casper), Id1, Ifng, Nfkb1, Ptcra
Cell Cycle
Ccnd1, Cdkn1a (p21Cip1, Waf1)
Cell Adhesion Molecules
Cd44, Erbb2 (Her-2, neu)
Cell Differentiation & Development
Dtx1, Hes1, Hes5, Hey1, Hey2, Heyl, Jag1, Krt1, Lfng, Lor, Notch1, Nr4a2 (Nurr1), Pparg
Neurogenesis
Erbb2 (Her-2, neu), Fos, Hes1, Hey1, Nr4a2 (Nurr1)
Immune Response
Chuk (IKBKA), Ifng, Il17b, Il2ra (Cd25), Nfkb1, Nfkb2, Stat6
Transcription Factors & Cofactors
Fos, Fosl1 (Fra-1), Hes1, Hes5, Hey1, Hey2, Heyl, Id1, Nfkb1, Nfkb2, Nr4a2 (Nurr1), Pparg, Stat6
Other Notch Signaling Genes
Cell Cycle
Axin1, Ccne1, Vegfd (Vegfd), Gsk3b
Cell Growth & Migration
Lrp5, Shh, Ccn4
Cell Proliferation & Differentiation
Ctnnb1, Vegfd (Vegfd), Gsk3b, Il6st (Gp130), Lmo2, Mmp7, Pax5, Runx1 (Aml1), Shh, Stil
Neurogenesis
Neurl1a (Neu1), Pax5, Pofut1, Zic2 (Hpe5)
Transcription Factors & Cofactors
Aes (Tle5, Groucho), Cbl, Ctnnb1, Gli1, Hoxb4, hr, Pax5, Runx1 (Aml1), Tle1
Other Notch Signaling Genes
Sel1l, Supt6
Pathways Crosstalking with Notch Signaling
Hedgehog Signaling
Gli1, Gsk3b, Shh, Smo, Sufu
WNT Signaling
Aes (Tle5, Groucho), Axin1, Ctnnb1, Fzd2, Fzd3, Fzd4, Fzd5, Fzd7, Gsk3b, Lrp5, Tle1, Ccn4, Wnt11