Target List
mTOR Complexes
mTORC1 Complex
MLST8 (GBL), MTOR, RPTOR
mTORC2 Complex
MLST8 (GBL), MTOR, RICTOR
mTOR Upstream Regulators
mTORC1 Positive Regulation
AKT1, AKT2, AKT3, IGF1, IKBKB, INS, INSR, IRS1, KRAS, MAPK1 (ERK2), MAPK1 (ERK2), MAPK3 (ERK1), MAPK3 (ERK1), NRAS, PDPK1, PIK3C3 (VPS34), PIK3CA (p110-alpha), LOC100622663 (PIK3CB), PIK3CD, PIK3CG, PIK3R2 (p85-BETA), PLD1, PLD2, RHEB, RPS6KA1, RPS6KA2, RPS6KA4, LOC100152046, RRAGA, RRAGC, RRAGD, TELO2
mTORC2 Positive Regulation
AKT1, AKT2, AKT3, MAPK1 (ERK2), MAPK1 (ERK2), MAPK3 (ERK1), MAPK3 (ERK1), PDPK1, PIK3C3 (VPS34), PIK3CA (p110-alpha), LOC100622663 (PIK3CB), PIK3CD, PIK3CG, PIK3R2 (p85-BETA), RHEB, RPS6KA1, RPS6KA2, RPS6KA4, LOC100152046
mTORC1 Negative Regulation
AKT1S1, CAB39, CAB39L, DDIT4 (REDD1), DDIT4L (REDD2), DEPTOR (DEPDC6), FKBP1A, FKBP8, IGFBP3, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, LOC100738310, PTEN, STK11 (LKB1), STRADB, TP53 (p53), TSC1, TSC2, YWHAQ (14-3-3θ)
mTORC2 Negative Regulation
CAB39, CAB39L, DDIT4 (REDD1), DDIT4L (REDD2), DEPTOR (DEPDC6), PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, LOC100738310, STK11 (LKB1), STRADB, TSC1, TSC2
mTOR Downstream Effectors
mTORC1 Positive Regulation
CHUK (IKKα), EIF4E, HIF1A, IKBKB, RPS6, RPS6KB1, RPS6KB2, TP53 (p53), VEGFA, VEGFB, VEGFC (VEGFC)
mTORC2 Positive Regulation
AKT1, CDC42, GSK3B, HSPA4 (HSP70), ILK, MYO1C, PRKCA, PRKCB, PRKCE, PRKCG, RHOA, RPS6KB1, SGK1
mTORC1 Negative Regulation
EIF4EBP1 (4E-BP1), EIF4EBP2, PPP2CA, PPP2R2B, PPP2R4, TP53 (p53), ULK1, ULK2
Cellular Processes
Amino Acid Response
PIK3C3 (VPS34), RRAGA, RRAGC, RRAGD
Angiogenesis
CHUK (IKKα), DDIT4 (REDD1), DDIT4L (REDD2), HIF1A, IKBKB, VEGFA, VEGFB, VEGFC (VEGFC)
Autophagy
PIK3C3 (VPS34), ULK1, ULK2
Cytoskeletal Organization
CDC42, PRKCA, PRKCB, PRKCE, PRKCG, RHOA
Growth Factor Response
BRAF, IGF1, IGFBP3, KRAS, MAPK1 (ERK2), MAPK1 (ERK2), MAPK3 (ERK1), MAPK3 (ERK1), NRAS, RPS6KA1, RPS6KA2, RPS6KA4, LOC100152046
Energy Stress
PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, LOC100738310
Insulin Signaling
AKT1, AKT2, AKT3, INS, INSR, IRS1, PDPK1, PIK3CA (p110-alpha), LOC100622663 (PIK3CB), PIK3CD, PIK3CG, PIK3R2 (p85-BETA), TP53 (p53)
Lipid Metabolism
BRAF, PLD1, PLD2
Translation
EIF4E, EIF4EBP1 (4E-BP1), EIF4EBP2, PPP2CA, PPP2R2B, PPP2R4, RPS6, RPS6KA1, RPS6KA2, RPS6KA4, LOC100152046, RPS6KB1, RPS6KB2