icon_0328_cc_gen_hmr_bacteria-s

IL-17 Signaling

Interleukin 17 (IL-17), also referred to as IL-17A, is a member of a family of cytokines that includes IL-17B, -17C, -17D, -17E and -17F. IL-17 function is essential to a subset of CD4+ T-Cells called T helper 17 (Th17) cells. IL-17A is a pro-inflammatory cytokine primarily secreted by T lymphocytes. It promotes expansion and recruitment of innate immune cells such as neutrophils and stimulates production of beta-defensins and other anti-microbial peptides....

IL-17 Signaling

Pathway Summary

Interleukin 17 (IL-17), also referred to as IL-17A, is a member of a family of cytokines that includes IL-17B, -17C, -17D, -17E and -17F. IL-17 function is essential to a subset of CD4+ T-Cells called T helper 17 (Th17) cells. IL-17A is a pro-inflammatory cytokine primarily secreted by T lymphocytes. It promotes expansion and recruitment of innate immune cells such as neutrophils and stimulates production of beta-defensins and other anti-microbial peptides.IL-17 binds to and signals through a transmembrane, heterotrimeric receptor complex that consists of IL-17 receptor A (IL-17RA), IL-17 receptor B (IL-17RB) and IL-17 receptor C (IL-17RC). IL-17A activates NF-kappaB and MAPK pathways via adapter molecules TRAF6 and ActI. Other signaling pathways like the Ras/ERK and the JAK/PI3K/AKT are also activated leading to the induction of pro-inflammatory cytokines, chemokines, matrix metalloproteinases and anti-microbial peptides. Thus, IL-17 is a unique cytokine that plays a central role in integrating adaptive and innate immune responses.

IL-17 Signaling Genes list

Explore Genes related to IL-17 Signaling

Products related to IL-17 Signaling

Explore products related to IL-17 Signaling
GeneGlobe ID: PAHS-150Z | Cat. No.: 330231 | RT2 Profiler PCR Arrays
RT² Profiler™ PCR Array Human Cytokines & Chemokines
RT2 Profiler PCR Array
Product Specification
GeneGlobe ID: PAHS-021Z | Cat. No.: 330231 | RT2 Profiler PCR Arrays
RT² Profiler™ PCR Array Human Common Cytokines
RT2 Profiler PCR Array
Product Specification
GeneGlobe ID: UPHS-150Z | Cat. No.: 249955 | QuantiNova LNA Probe PCR Focus Panels
QuantiNova LNA Probe PCR Focus Panel Human Cytokines & Chemokines
QuantiNova LNA Probe PCR Focus Panel
Product Specification
GeneGlobe ID: UPHS-021Z | Cat. No.: 249955 | QuantiNova LNA Probe PCR Focus Panels
QuantiNova LNA Probe PCR Focus Panel Human Common Cytokines
QuantiNova LNA Probe PCR Focus Panel
Product Specification
GeneGlobe ID: SBHS-150Z | Cat. No.: 249950 | QuantiNova LNA PCR Focus Panels
QuantiNova LNA PCR Focus Panel Human Cytokines & Chemokines
QuantiNova LNA PCR Focus Panel
Product Specification
GeneGlobe ID: SBHS-021Z | Cat. No.: 249950 | QuantiNova LNA PCR Focus Panels
QuantiNova LNA PCR Focus Panel Human Common Cytokines
QuantiNova LNA PCR Focus Panel
Product Specification

Didn't find what you're looking for?

Discover other products relevant to this gene list with our Panel Finder. Check it out.