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Small Cell Lung Cancer Signaling

Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm with a high metastatic potential and the development of resistance to chemotherapy. It accounts for approximately 20% of all lung cancer cases. Altered expression of oncogenic and tumor suppressor genes play an important role in SCLC. For example, dominant oncogenes of the MYC family are frequently overexpressed in SCLC. Such overexpression leads to rapid cellular proliferation and loss of terminal differentiation...

Small Cell Lung Cancer Signaling

Pathway Summary

Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm with a high metastatic potential and the development of resistance to chemotherapy. It accounts for approximately 20% of all lung cancer cases. Altered expression of oncogenic and tumor suppressor genes play an important role in SCLC. For example, dominant oncogenes of the MYC family are frequently overexpressed in SCLC. Such overexpression leads to rapid cellular proliferation and loss of terminal differentiation. Mutations or deletions to tumor supressor genes like PTEN, RB and p53 interfere with cellular processes resulting in reduced apoptosis, increased proliferation and impaired cell cycle arrest thus contributing to the progression of the tumor.Other mutants include FHIT, a diadenosine triphosphate hydrolase which is thought to have an indirect role in proapoptosis and cell-cycle control. ECM and Bcl-2 protect SCLC cells against chemotherapy-induced cell death thus contributing to the disease.Retinoic acid plays an important role in lung development and differentiation acting primarily via nuclear receptors encoded by the retinoic acid receptor (RAR)-β gene. Promoter methylation and silencing of the RARβ gene is frequently seen in SCLC.

Small Cell Lung Cancer Signaling Genes list

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Products related to Small Cell Lung Cancer Signaling

Explore products related to Small Cell Lung Cancer Signaling
GeneGlobe ID: YHS-005Z | Cat. No.: | QIAseq Targeted cfDNA Ultra Panels
QIAseq Targeted cfDNA Ultra Human Lung Cancer Panel
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GeneGlobe ID: PAHS-177Z | Cat. No.: 330231 | RT2 Profiler PCR Arrays
RT² Profiler™ PCR Array Human MYC Targets
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RT² Profiler™ PCR Array Human Cancer PathwayFinder™
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GeneGlobe ID: PAHS-134Z | Cat. No.: 330231 | RT2 Profiler PCR Arrays
RT² Profiler™ PCR Array Human Lung Cancer
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GeneGlobe ID: PHS-3000Z | Cat. No.: | QIAseq Targeted DNA Pro Panels
QIAseq Targeted DNA Pro Human Comprehensive Cancer Research Panel
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GeneGlobe ID: PHS-005Z | Cat. No.: | QIAseq Targeted DNA Pro Panels
QIAseq Targeted DNA Pro Human Lung Cancer Research Panel
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GeneGlobe ID: PHS-3100Z | Cat. No.: | QIAseq Targeted DNA Pro Panels
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Kit containing ALL reagents (except indexes) for targeted DNA sequencing
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GeneGlobe ID: UPHS-134Z | Cat. No.: 249955 | QuantiNova LNA Probe PCR Focus Panels
QuantiNova LNA Probe PCR Focus Panel Human Lung Cancer
QuantiNova LNA Probe PCR Focus Panel
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GeneGlobe ID: UPHS-177Z | Cat. No.: 249955 | QuantiNova LNA Probe PCR Focus Panels
QuantiNova LNA Probe PCR Focus Panel Human MYC Targets
QuantiNova LNA Probe PCR Focus Panel
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GeneGlobe ID: SBHS-033Z | Cat. No.: 249950 | QuantiNova LNA PCR Focus Panels
QuantiNova LNA PCR Focus Panel Human Cancer PathwayFinder
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GeneGlobe ID: SBHS-177Z | Cat. No.: 249950 | QuantiNova LNA PCR Focus Panels
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GeneGlobe ID: JHS-002Z | Cat. No.: | QIAseq RNA Fusion XP Panels
QIAseq RNA Fusion XP Solid Tumor Panel
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GeneGlobe ID: SBHS-134Z | Cat. No.: 249950 | QuantiNova LNA PCR Focus Panels
QuantiNova LNA PCR Focus Panel Human Lung Cancer
QuantiNova LNA PCR Focus Panel
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GeneGlobe ID: JHS-003Z | Cat. No.: | QIAseq RNA Fusion XP Panels
QIAseq RNA Fusion XP Lung Cancer Panel
Kit containing ALL reagents (except indexes) for fusion and gene expression profiling by digital RNAseq
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GeneGlobe ID: UPHS-033Z | Cat. No.: 249955 | QuantiNova LNA Probe PCR Focus Panels
QuantiNova LNA Probe PCR Focus Panel Human Cancer PathwayFinder
QuantiNova LNA Probe PCR Focus Panel
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