STAT3 Gene Summary
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. This gene also plays a role in regulating host response to viral and bacterial infections. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. [provided by RefSeq, Aug 2020]
Details
| Type | Protein Coding |
| Official Symbol | STAT3 |
| Official Name | signal transducer and activator of transcription 3 [Source:HGNC Symbol;Acc:HGNC:11364] |
| Ensembl ID | ENSG00000168610 |
| Bio databases IDs | |
| Aliases | signal transducer and activator of transcription 3 |
| Synonyms | 1110034C02Rik,acute-phase response factor,ADMIO,ADMIO1,APRF,HIES,MGC16063,signal transducer and activator of transcription 3,Stat3 alpha isoform,Stat3 beta isoform,Stat3 delta,Stat3 α isoform,Stat3 β isoform,Stat3 δ |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein dimerization
- transcription regulator
- CCR chemokine receptor binding
- STAT protein, DNA binding domain
- C domain
- protein binding activity, bridging
- transcription activation domain
- transcription factor binding
- coiled-coil domain
- chromatin binding
- identical protein binding
- Sh3 domain binding motif
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- STAT_CCD
- Src homology 2 (SH2) domain
- STAT protein, protein interaction domain
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- activation domain
- ligand-dependent nuclear receptor interactor
- acetylation site
- protein kinase binding
- DNA binding domain
- nucleic acid binding
- protein phosphatase binding
- alpha helix
- linker domain
- protein binding
- receptor binding
- Src-homology 2 binding domain
- sequence-specific DNA binding
- STAT protein, all-alpha domain
- DNA binding
- RNA binding
- phosphorylation site
- minimal transactivation domain
- double-stranded DNA binding
- protein homodimerization
- ERK phosphorylation site
- CAD domain
- transcription factor activity
- DNA-binding domain of Signal Transducer and Activator of Transcription (STAT)
- tyrosine phosphorylation site
Pathways
Biological processes and signaling networks where the STAT3 gene plays a role, providing insight into its function and relevance in health or disease.
- Acute Myeloid Leukemia Signaling
- CD40 Signaling
- EGF Signaling
- Ephrin A Signaling
- ErbB2-ErbB3 Signaling
- FGF Signaling
- FLT3 Signaling in Hematopoietic Progenitor Cells
- Glucocorticoid Receptor Signaling
- GM-CSF Signaling
- Growth Hormone Signaling
- IGF-1 Signaling
- IL-22 Signaling
- IL-6 Signaling
- JAK/Stat Signaling
- Leptin Signaling in Obesity
- Oncostatin M Signaling
- Prolactin Signaling
- Role of JAK1 and JAK3 in γc Cytokine Signaling
- Role of JAK1, JAK2 and TYK2 in Interferon Signaling
- SPINK1 General Cancer Pathway
- T Helper Cell Differentiation
- Th1 Pathway
- Transcriptional Regulatory Network in Embryonic Stem Cells
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-Hodgkin disease
- lymphomagenesis
- cancer
- hematologic cancer
- lymphoid cancer
- hematological neoplasia
- lymphatic neoplasia
- prostate cancer
- chronic lymphocytic leukemia
- Waldenström macroglobulinemia
role in cell
- expression in
- activation in
- phosphorylation in
- binding in
- differentiation
- production in
- apoptosis
- response
- activity
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- plasma membrane fraction
- early endosomal fractions
- nuclear fraction
- raft fractions
- soluble fraction
- detergent-insoluble fractions
- membrane fraction
- glutaminergic synapse
- nuclear lipid microdomain
- Cytoplasm
- cellular membrane
- focal adhesions
- Plasma Membrane
- Mitochondria
- cytosol
- mitochondrial inner membrane
- nuclear foci
- nucleoplasm
- neuromuscular junctions
- growth cone
- synapse
- membrane rafts
- chromatin
- postsynaptic density
- axon terminals
- plasma
- cytoplasmic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the STAT3 gene, providing context for its role in the cell.
biological PROCESS
Functions and activities the gene product is involved in
- interleukin-9-mediated signaling pathway
- interleukin-2-mediated signaling pathway
- interleukin-11-mediated signaling pathway
- transforming growth factor beta receptor signaling pathway
- positive regulation of erythrocyte differentiation
- positive regulation of NF-kappaB transcription factor activity
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of angiogenesis
- JAK-STAT cascade
- inflammatory response
- negative regulation of primary miRNA processing
- positive regulation of transcription, DNA-dependent
- cellular response to leptin stimulus
- T-helper 17 cell lineage commitment
- energy homeostasis
- positive regulation of tumor necrosis factor production
- regulation of cell cycle
- positive regulation vascular endothelial growth factor production
- growth hormone receptor signaling pathway
- mRNA transcription from RNA polymerase II promoter
- JAK-STAT cascade involved in growth hormone signaling pathway
- leptin-mediated signaling pathway
- negative regulation of inflammatory response
- response to leptin stimulus
- response to peptide hormone stimulus
- negative regulation of gene expression
- positive regulation of interleukin-8 production
- eye photoreceptor cell differentiation
- positive regulation of gene expression
- protein import into nucleus
- negative regulation of autophagy
- glucose homeostasis
- response to estradiol stimulus
- cellular response to hormone stimulus
- sexual reproduction
- positive regulation of interleukin-6 production
- T-helper 17 type immune response
- positive regulation of cell migration
- cell proliferation
- retinal rod cell differentiation
- regulation of multicellular organism growth
- negative regulation of cell proliferation
- nervous system development
- negative regulation of glycolysis
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of Notch signaling pathway
- eating behavior
- negative regulation of transcription from RNA polymerase II promoter
- protein kinase B signaling cascade
- cytokine-mediated signaling pathway
- negative regulation of stem cell differentiation
- somatic stem cell maintenance
- interleukin-6-mediated signaling pathway
- phosphorylation
- negative regulation of neuron migration
- intracellular receptor mediated signaling pathway
- astrocyte differentiation
- signal transduction
- radial glial cell differentiation
- regulation of transcription, DNA-dependent
- defense response
- regulation of cell proliferation
- regulation of feeding behavior
- regulation of transcription from RNA polymerase II promoter
- temperature homeostasis
- cell differentiation
- interleukin-15-mediated signaling pathway
- positive regulation of interleukin-10 production
- positive regulation of interleukin-1 beta production
cellular COMPONENT
Where in the cell the gene product is active
- transcription factor complex
- nucleus
- cytoplasm
- cytosol
- chromatin
- plasma membrane
- nucleoplasm
molecular FUNCTION
What the gene product does at the molecular level
- chromatin DNA binding
- protein kinase binding
- identical protein binding
- protein homodimerization activity
- protein phosphatase binding
- signaling adaptor activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- protein dimerization activity
- receptor binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity
- DNA binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
- primary miRNA binding