PPP2R2A Gene Summary
The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an alpha isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]
Details
| Type | Protein Coding |
| Official Symbol | PPP2R2A |
| Official Name | protein phosphatase 2 regulatory subunit Balpha [Source:HGNC Symbol;Acc:HGNC:9304] |
| Ensembl ID | ENSG00000221914 |
| Bio databases IDs | |
| Aliases | protein phosphatase 2 regulatory subunit Balpha, PP2A subunit B isoform alpha |
| Synonyms | 2410004D02Rik,2ABA,B55A,B55ALPHA,B55 α,B/PR55,MGC52248,mKIAA1541,PP2A,PP2A B-alpha,PP2A B-α,PR52A,PR55A,PR55alpha,protein phosphatase 2 regulatory subunit Balpha,protein phosphatase 2, regulatory subunit B, alpha,protein phosphatase 2, regulatory subunit B, α |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- beta propeller
- binding protein
- tau protein binding
- phosphoprotein phosphatase
- protein phosphatase binding
- protein binding activity, bridging
- phosphatase
- protein phosphatase regulator
- WD40
- protein binding
Pathways
Biological processes and signaling networks where the PPP2R2A gene plays a role, providing insight into its function and relevance in health or disease.
- AMPK Signaling
- ATM Signaling
- Autophagy
- Cardiac β-adrenergic Signaling
- CDK5 Signaling
- Cell Cycle Regulation by BTG Family Proteins
- Ceramide Signaling
- Cyclins and Cell Cycle Regulation
- Dopamine Receptor Signaling
- Dopamine-DARPP32 Feedback in cAMP Signaling
- ERK/MAPK Signaling
- HIPPO signaling
- ILK Signaling
- Mitotic Roles of Polo-Like Kinase
- mTOR Signaling
- Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
- Regulation of eIF4 and p70S6K Signaling
- Role of CHK Proteins in Cell Cycle Checkpoint Control
- Role of Tissue Factor in Cancer
- Telomerase Signaling
- Tight Junction Signaling
- WNT/β-catenin Signaling
- Xenobiotic Metabolism Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- experimental autoimmune encephalomyelitis
- organismal death
- aortic valve calcification
- non-small cell lung cancer
- preeclampsia
- infection by HIV-1
- productive infection by HIV-1
role in cell
- expression in
- apoptosis
- activation in
- cell death
- phosphorylation in
- degradation in
- survival
- migration
- binding in
- josamycin sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- cytosol
- nucleoplasm
- growth cone
- synapse
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the PPP2R2A gene, providing context for its role in the cell.
biological PROCESS
Functions and activities the gene product is involved in
- protein dephosphorylation
- response to morphine
cellular COMPONENT
Where in the cell the gene product is active
- cytosol
- protein phosphatase type 2A complex
- nucleoplasm
molecular FUNCTION
What the gene product does at the molecular level
- protein binding
- protein phosphatase regulator activity