UGGT1

UGGT1 Gene Summary

UDP-glucose:glycoprotein glucosyltransferase (UGT) is a soluble protein of the endoplasmic reticulum (ER) that selectively reglucosylates unfolded glycoproteins, thus providing quality control for protein transport out of the ER.[supplied by OMIM, Oct 2009]

Details

Type
Nonsense Mediated Decay
Official Symbol
UGGT1
Official Name
UDP-glucose glycoprotein glucosyltransferase 1 [Source:HGNC Symbol;Acc:HGNC:15663]
Ensembl ID
ENSG00000136731
Bio databases IDs NCBI: 56886 Ensembl: ENSG00000136731
Aliases UDP-glucose glycoprotein glucosyltransferase 1
Synonyms
0910001L17RIK,A930007H10RIK,AA589501,AI448372,C820010P03Rik,GT,HUGT1,rUGT1,UDP-glucose glycoprotein glucosyltransferase 1,UGCGL1,UGGG1,Uggt,UGT1,Ugtr
Species
Human, Homo sapiens

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • thioredoxin-like domain
  • catalytic domain
  • non-catalytic domain
  • Glucosyltransferase 24
  • UDP-glucose:glycoprotein glucosyltransferase
  • enzyme
  • protein binding
  • glycosyltransferase family A

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
  • DPF2
  • TRIM67
  • CUL1
  • PTPRN
  • RAN
  • PTEN
  • TGOLN2
  • HSP90AB1
  • LRRC59
  • RPA1
disease
regulated by
  • IL4
  • MTOR
  • LGI1
  • ammonium
  • amentoflavone
  • oxaliplatin
  • TRAPPC1
  • TTC17
regulates
  • SERPINA1
  • PMP22
  • UGGT2
role in cell

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • Nucleus
  • Golgi Apparatus
  • Endoplasmic Reticulum
  • ER-to-Golgi intermediate compartment
  • cytosol
  • endoplasmic reticulum lumen
  • nuclear envelope
  • smooth endoplasmatic reticulum
  • rough endoplasmatic reticulum
  • pre-Golgi intermediate vesicles

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the UGGT1 gene, providing context for its role in the cell.

BIOLOGICAL PROCESS

Functions and activities the gene product is involved in
  • 'de novo' posttranslational protein folding
  • protein N-linked glycosylation via asparagine

CELLULAR COMPONENT

Where in the cell the gene product is active
  • endoplasmic reticulum lumen
  • extracellular vesicular exosome
  • macromolecular complex
  • endoplasmic reticulum
  • endoplasmic reticulum-Golgi intermediate compartment

MOLECULAR FUNCTION

What the gene product does at the molecular level
  • protein binding
  • unfolded protein binding
  • UDP-glucose:glycoprotein glucosyltransferase activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.