RFC4 Gene Summary
The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kD. This gene encodes the 37 kD subunit. This subunit forms a core complex with the 36 and 40 kDa subunits. The core complex possesses DNA-dependent ATPase activity, which was found to be stimulated by PCNA in an in vitro system. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | RFC4 |
| Official Name | replication factor C subunit 4 [Source:HGNC Symbol;Acc:HGNC:9972] |
| Ensembl ID | ENSG00000163918 |
| Bio databases IDs | |
| Aliases | replication factor C subunit 4, A1 37 kDa subunit, activator 1 37 kDa subunit, RFC 37 kDa subunit |
| Synonyms | A1,AI894123,MRMNS,p37,replication factor C (activator 1) 4,replication factor C subunit 4,RFC37,RFC P37 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- single-stranded DNA dependent ATP dependent DNA helicase
- DNA polymerase III, delta subunit
- ATP-binding domain
- enzyme binding
- Replication factor C C-terminal domain
- enzyme
- protein binding
- AAA domain
- ATPase family associated with various cellular activities (AAA)
- helical lid domain of clamp loader-like AAA+ proteins
- DNA clamp loader
- P-loop containing Nucleoside Triphosphate Hydrolases
- ATPases associated with a variety of cellular activities
Pathways
Biological processes and signaling networks where the RFC4 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- epithelial cancer
- neoplasia
- hepatocellular carcinoma
- colon cancer
- breast cancer
- lung squamous cell carcinoma
- Morimoto-Ryu-Malicdan neuromuscular syndrome
- non-small cell lung cancer
- lung adenocarcinoma
role in cell
- expression in
- growth
- binding in
- sphere formation
- invasion by
- signaling in
- processing in
- K48 polyubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
- chromatin
- replication fork
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the RFC4 gene, providing context for its role in the cell.
biological PROCESS
Functions and activities the gene product is involved in
- DNA repair
- DNA duplex unwinding
- DNA strand elongation involved in DNA replication
- positive regulation of DNA-directed DNA polymerase activity
- DNA-dependent DNA replication
cellular COMPONENT
Where in the cell the gene product is active
- Ctf18 RFC-like complex
- Elg1 RFC-like complex
- nucleus
- DNA replication factor C complex
- nucleoplasm
molecular FUNCTION
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- DNA binding
- DNA clamp loader activity
- protein binding
- single-stranded DNA-dependent ATP-dependent DNA helicase activity